Drug Information

Drug General Information
Drug ID
D0C9ET
Former ID
DNAP001271
Drug Name
Aflibercept
Synonyms
Ziv-Aflibercept; Zaltrap (TN); VEGF Trap; VEGF Trap-Eye
Indication Metastatic colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Approved [551871]
Company
Sanofi
CAS Number
CAS 862111-32-8
SuperDrug ATC ID
S01LA05
Target and Pathway
Target(s) Vascular endothelial growth factor A Target Info Modulator [551871]
Vascular endothelial growth factor B Target Info Modulator [551871]
Placental growth factor Target Info Modulator [551871]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Pancreatic cancer
Bladder cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
Pathways in cancerhsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Metabolic pathways
NetPath Pathway IL2 Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
Leptin Signaling Pathway
FSH Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
S1P3 pathway
Signaling events mediated by TCPTP
S1P1 pathway
Alpha9 beta1 integrin signaling events
Integrins in angiogenesis
VEGFR1 specific signals
HIF-1-alpha transcription factor networkvegfr1_pathway:VEGFR1 specific signals
Reactome Platelet degranulation
Regulation of gene expression by Hypoxia-inducible Factor
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-114608:Platelet degranulation
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways SIDS Susceptibility Pathways
Hypertrophy Model
Endochondral Ossification
Focal Adhesion
Differentiation Pathway
Bladder Cancer
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
Nifedipine Activity
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Allograft Rejection
Integrated Breast Cancer Pathway
Signaling by VEGF
Heart Development
AngiogenesisWP306:Focal Adhesion
Heart DevelopmentWP410:Diurnally Regulated Genes with Circadian Orthologs
Post-translational modification: synthesis of GPI-anchored proteins
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015