Drug Information

Drug General Information
Drug ID
D0E7VO
Former ID
DIB019413
Drug Name
compound 2c
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532818]
Formula
C19H20FN7O
InChI
InChI=1S/C19H20FN7O/c1-11(2)28-18-8-17(25-26-18)27-10-22-15-6-7-16(24-19(15)27)23-12(3)14-5-4-13(20)9-21-14/h4-12H,1-3H3,(H,23,24)(H,25,26)/t12-/m0/s1
InChIKey
FZBVNCFBCNXULH-LBPRGKRZSA-N
PubChem Compound ID
59627005
PubChem Substance ID
141373915, 163323400, 163341815, 163544882, 224460847, 229764455, 243905207, 249565818
Target and Pathway
Target(s) Trk receptor Target Info Inhibitor [532818]
WNK lysine deficient protein kinase 3 Target Info Inhibitor [532818]
phosphorylase kinase, gamma 2 (testis) Target Info Inhibitor [532818]
FGR proto-oncogene, Src family tyrosine kinase Target Info Inhibitor [532818]
mRNA of Abl Target Info Inhibitor [532818]
Tyrosine-protein kinase BTK Target Info Inhibitor [532818]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [532818]
testis-specific serine kinase 2 Target Info Inhibitor [532818]
salt-inducible kinase 1 Target Info Inhibitor [532818]
FL cytokine receptor Target Info Inhibitor [532818]
KEGG Pathway ErbB signaling pathway
Ras signaling pathway
Cell cycle
Axon guidance
Neurotrophin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Pathways in cancer
MicroRNAs in cancer
Chronic myeloid leukemia
Viral myocarditishsa04064:NF-kappa B signaling pathway
Osteoclast differentiation
Platelet activation
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Primary immunodeficiencyhsa04010:MAPK signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Proteoglycans in cancer
Prostate cancer
Melanoma
Central carbon metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Axon guidance mediated by Slit/RoboP00010:B cell activationP00005:Angiogenesis
FGF signaling pathway
Pathway Interaction Database p73 transcription factor network
ATM pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
FAS (CD95) signaling pathway
Class I PI3K signaling events
EPO signaling pathwayglypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathway
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet productionR-HSA-166058:MyD88:Mal cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membraneWP710:DNA Damage Response (only ATM dependent)
DNA Damage Response
ErbB Signaling Pathway
EGF/EGFR Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet production
TP53 Network
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP304:Kit receptor signaling pathway
MyD88:Mal cascade initiated on plasma membrane
Signaling by the B Cell Receptor (BCR)
DAP12 interactions
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
Regulation of toll-like receptor signaling pathway
IL-5 Signaling PathwayWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Signaling Pathways in Glioblastoma
Neural Crest Differentiation
Signaling by FGFR
References
Ref 532818Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9.
Ref 532818Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9.