Drug Information

Drug General Information
Drug ID
D0J4LI
Former ID
DIB003175
Drug Name
Thymoctonan
Synonyms
FCE-25388; Thymic humoral factor gamma-2; Thymus humoral factor gamma-2; THF-gamma-2
Drug Type
Small molecular drug
Indication Immuno-stimulant [ICD10:C00-C97] Phase 2 [521442]
Company
Weizmann Institute of Science
Formula
C43H67N9O13
Canonical SMILES
N1([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(<br />C)C)Cc2ccccc2)CCCCN)CCC1)C(=O)CNC(=O)[C@@H](NC(=O)[C@@H<br />](NC(=O)[C@H](CC(C)C)N)CCC(=O)O)CC(=O)O
CAS Number
CAS 107489-37-2
PubChem Compound ID
65901
Target and Pathway
Target(s) Interleukin-2 Target Info Modulator [534072]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infection
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
Graft-versus-host disease
NetPath Pathway IL-7 Signaling Pathway
TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
SHP2 signaling
Regulation of Telomerase
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
AP-1 transcription factor network
IL23-mediated signaling events
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways Cytokines and Inflammatory Response
IL-2 Signaling Pathway
Inflammatory Response Pathway
Aryl Hydrocarbon Receptor Pathway
Interleukin-2 signaling
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Corticotropin-releasing hormone
Allograft Rejection
Arylhydrocarbon receptor (AhR) signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Folate Metabolism
IL-5 Signaling Pathway
References
Ref 521442ClinicalTrials.gov (NCT00002435) A Study of Thymic Humoral Factor (THF Gamma 2) in HIV-Infected Patients. U.S. National Institutes of Health.
Ref 534072Evaluation of efficacy and safety of thymus humoral factor-gamma 2 in the management of chronic hepatitis B. J Hepatol. 1995 Jul;23(1):21-7.