TTD | Drug: D0PN8H

Drug General Information
Drug ID	D0PN8H
Former ID	DNCL003489
Drug Name	Pacritinib
Synonyms	JAK inhibitor (alone or in combination)s
Drug Type	Small molecular drug
Indication	Myelofibrosis [ICD9: 208.9, 289.83, 709.2; ICD10:C94.4, D47.4]		Phase 3	[524636], [542744], [550572]
Company	Cell Therapeutics
Formula	C28H32N4O3
InChI	InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+
InChIKey	HWXVIOGONBBTBY-ONEGZZNKSA-N
PubChem Compound ID	46216796
PubChem Substance ID	104174247, 120480990, 137452593, 160678787, 162108696, 163349336, 172121855, 172919349, 184816010, 198949866, 210275500, 210281148, 223366124, 226088077, 227352033, 252110278, 252451856, 252472910
Target and Pathway
Target(s)	FL cytokine receptor	Target Info	Modulator	[543494]
Target(s)	Tyrosine-protein kinase JAK2	Target Info	Modulator	[550433]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Hematopoietic cell lineage
	Pathways in cancer
	Transcriptional misregulation in cancer
	Acute myeloid leukemia
	Central carbon metabolism in cancerhsa04062:Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Cholinergic synapse
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infection
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	ErbB4 signaling events
	GMCSF-mediated signaling events
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by PTP1B
	IL12-mediated signaling events
	S1P3 pathway
	SHP2 signaling
	CXCR4-mediated signaling events
	IL5-mediated signaling events
	IFN-gamma pathway
	ErbB2/ErbB3 signaling events
	IL3-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	IL23-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	Notch-mediated HES/HEY network
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	Prolactin receptor signaling
	RMTs methylate histone arginines
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF activation
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interleukin receptor SHC signaling
	Growth hormone receptor signaling
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Type II interferon signaling (IFNG)
	Notch Signaling Pathway
	EPO Receptor Signaling
	EGF/EGFR Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Mesodermal Commitment Pathway
	Interleukin-2 signaling
	Signaling by SCF-KIT
	Prolactin receptor signaling
	Growth hormone receptor signaling
	JAK/STAT
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TSLP Signaling Pathway
	IL17 signaling pathway
	Leptin signaling pathway
	TSH signaling pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Factors involved in megakaryocyte development and platelet production
	IL-5 Signaling Pathway
References
Ref 524636	ClinicalTrials.gov (NCT02055781) Oral Pacritinib Versus Best Available Therapy to Treat Myelofibrosis With Thrombocytopenia. U.S. National Institutes of Health.
Ref 542744	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7793).
Ref 550572	Clinical pipeline report, company report or official report of CTI BioPharma.
Ref 543494	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807).
Ref 550433	National Cancer Institute Drug Dictionary (drug id 609888).

Drug Information