Drug Information

Drug General Information
Drug ID
D00RNZ
Former ID
DNC010064
Drug Name
7-(benzyloxy)-2H-chromen-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530514]
Formula
C16H12O3
Canonical SMILES
C1=CC=C(C=C1)COC2=CC3=C(C=C2)C=CC(=O)O3
InChI
1S/C16H12O3/c17-16-9-7-13-6-8-14(10-15(13)19-16)18-11-12-4-2-1-3-5-12/h1-10H,11H2
InChIKey
QDLFCBKKECTJSK-UHFFFAOYSA-N
PubChem Compound ID
910172
Target and Pathway
Target(s) Carbonic anhydrase IV Target Info Inhibitor [530514]
Carbonic anhydrase Target Info Inhibitor [530514]
Carbonic anhydrase IX Target Info Inhibitor [530514]
Carbonic anhydrase XIV Target Info Inhibitor [530514]
Carbonic anhydrase XII Target Info Inhibitor [530514]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.