Drug Information

Drug General Information
Drug ID
D0X5HL
Former ID
DNC011082
Drug Name
N1-(naphthalen-1-yl)ethane-1,2-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530998]
Formula
C12H14N2
Canonical SMILES
C1=CC=C2C(=C1)C=CC=C2NCCN
InChI
1S/C12H14N2/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12/h1-7,14H,8-9,13H2
InChIKey
NULAJYZBOLVQPQ-UHFFFAOYSA-N
PubChem Compound ID
15107
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [530998]
Carbonic anhydrase IV Target Info Inhibitor [530998]
Carbonic anhydrase VI Target Info Inhibitor [530998]
Carbonic anhydrase IX Target Info Inhibitor [530998]
Carbonic anhydrase XIV Target Info Inhibitor [530998]
Carbonic anhydrase XII Target Info Inhibitor [530998]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.