Drug General Information
Drug ID
D05VSK
Former ID
DNC010061
Drug Name
ETHOXYCOUMARIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530514]
Formula
C11H10O3
Canonical SMILES
CCOC1=CC2=C(C=C1)C=CC(=O)O2
InChI
1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3
InChIKey
LIFAQMGORKPVDH-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [530514]
Carbonic anhydrase IX Target Info Inhibitor [530514]
Carbonic anhydrase XIV Target Info Inhibitor [530514]
Carbonic anhydrase XII Target Info Inhibitor [530514]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.