TTD | Drug: D0ON2Z

Drug General Information
Drug ID	D0ON2Z
Former ID	DNC006431
Drug Name	RAZAXABAN
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530655]
Formula	C24H21ClF4N8O2
Canonical SMILES	CN(C)CC1=NC=CN1C2=CC(=C(C=C2)NC(=O)C3=CC(=NN3C4=CC5=C(C<br />=C4)ON=C5N)C(F)(F)F)F
InChI	1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37)
InChIKey	OFJRNBWSFXEHSA-UHFFFAOYSA-N
PubChem Compound ID	204101
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Inhibitor	[529078]
	Coagulation Factor Va	Target Info	Inhibitor	[527987]
	Coagulation factor IIa	Target Info	Inhibitor	[530655]
	Coagulation factor IX	Target Info	Inhibitor	[527987]
KEGG Pathway	Complement and coagulation cascadeshsa04610:Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeletonhsa04610:Complement and coagulation cascades
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Blood coagulationP00011:Blood coagulationP00011:Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactionsthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
	Angiopoietin receptor Tie2-mediated signaling
	FOXA2 and FOXA3 transcription factor networks
	PAR4-mediated thrombin signaling events
	Syndecan-4-mediated signaling events
	PAR1-mediated thrombin signaling events
PathWhiz Pathway	CoagulationPW000562:CoagulationPW000047:Vitamin K Metabolism
PathWhiz Pathway	CoagulationPW000562:Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-114608:Platelet degranulation
	COPII (Coat Protein 2) Mediated Vesicle Transport
	Cargo concentration in the ERR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Cell surface interactions at the vascular wall
	Peptide ligand-binding receptors
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	G alpha (q) signalling events
	Thrombin signalling through proteinase activated receptors (PARs)R-HSA-140834:Extrinsic Pathway of Fibrin Clot Formation
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
	Regulation of Actin Cytoskeleton
	IL1 and megakaryotyces in obesity
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Gastrin-CREB signalling pathway via PKC and MAPK
	Thrombin signalling through proteinase activated receptors (PARs)
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signaling
	Formation of Fibrin Clot (Clotting Cascade)
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
References
Ref 530655	Bioorg Med Chem Lett. 2010 Feb 15;20(4):1373-7. Epub 2010 Jan 11.Phenyltriazolinones as potent factor Xa inhibitors.
Ref 527987	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1795-8. Epub 2006 Jan 24.Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
Ref 529078	J Med Chem. 2007 Nov 1;50(22):5339-56. Epub 2007 Oct 3.Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban,BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Ref 530655	Bioorg Med Chem Lett. 2010 Feb 15;20(4):1373-7. Epub 2010 Jan 11.Phenyltriazolinones as potent factor Xa inhibitors.

Drug Information