Drug Information

Drug General Information
Drug ID
D0RB0D
Former ID
DNC010066
Drug Name
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530514]
Formula
C11H8O5
Canonical SMILES
COC1=CC2=C(C=C1)C(=CC(=O)O2)C(=O)O
InChI
1S/C11H8O5/c1-15-6-2-3-7-8(11(13)14)5-10(12)16-9(7)4-6/h2-5H,1H3,(H,13,14)
InChIKey
IHHLDCASADSHEG-UHFFFAOYSA-N
PubChem Compound ID
44268050
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [530514]
Carbonic anhydrase I Target Info Inhibitor [530514]
Carbonic anhydrase IX Target Info Inhibitor [530514]
Carbonic anhydrase XIV Target Info Inhibitor [530514]
Carbonic anhydrase XII Target Info Inhibitor [530514]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.