TTD | Drug: D05FFB

Drug General Information
Drug ID	D05FFB
Former ID	DNC005818
Drug Name	5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527769]
Formula	C17H14N2O
Canonical SMILES	CC1=C2C(=C(C3=C1C=CN=C3)C)C4=C(N2)C=CC(=C4)O
InChI	1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3
InChIKey	QZTWUDDGLIDXSE-UHFFFAOYSA-N
PubChem Compound ID	91643
Target and Pathway
Target(s)	Alpha platelet-derived growth factor receptor	Target Info	Inhibitor	[527769]
	FGF-3 receptor	Target Info	Inhibitor	[527769]
	Mast/stem cell growth factor receptor	Target Info	Inhibitor	[527769]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Gap junction
	Regulation of actin cytoskeleton
	HTLV-I infection
	Pathways in cancer
	MicroRNAs in cancer
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04010:MAPK signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Bladder cancer
	Central carbon metabolism in cancerhsa04014:Ras signaling pathway
	Hematopoietic cell lineage
	Melanogenesis
	Acute myeloid leukemia
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_15:IL3 Signaling Pathway
	IL4 Signaling Pathway
	KitReceptor Signaling Pathway
PANTHER Pathway	Angiogenesis
PANTHER Pathway	PDGF signaling pathwayP00021:FGF signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
	PDGFR-alpha signaling pathway
	PDGF receptor signaling networkcmyb_pathway:C-MYB transcription factor network
	Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome	PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascadeR-HSA-2033514:FGFR3 mutant receptor activationR-HSA-1257604:PIP3 activates AKT signaling
	Regulation of KIT signaling
	RAF/MAP kinase cascade
WikiPathways	Regulation of Actin Cytoskeleton
	Osteoblast Signaling
	Focal Adhesion
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Signaling Pathways in Glioblastoma
	Signaling by PDGF
	AngiogenesisWP51:Regulation of Actin Cytoskeleton
	Endochondral Ossification
	Bladder Cancer
	Neural Crest Differentiation
	Signaling by FGFRWP304:Kit receptor signaling pathway
	Differentiation Pathway
	Signaling by SCF-KIT
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
References
Ref 527769	J Med Chem. 2005 Oct 6;48(20):6194-201.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.
Ref 527769	J Med Chem. 2005 Oct 6;48(20):6194-201.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.

Drug Information