Drug Information

Drug General Information
Drug ID
D06RUK
Former ID
DIB013138
Drug Name
Combotox
Synonyms
IMTOX 22; Anti CD22/N97A; Anti CD22/ricin; Anti CD19 + anti CD22/N97A; Ricin-conjugated anti-CD22 and anti-CD19; IgG-RFB4-dgA and IgG-HD37-dgA
Indication Leukemia [ICD9: 208.9; ICD10:C90-C95] Phase 1 [548715]
Company
University of Texas Southwestern Medical Center
Target and Pathway
Target(s) B-cell receptor CD22 Target Info Modulator
B-lymphocyte antigen CD19 Target Info Modulator
KEGG Pathway Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
B cell receptor signaling pathwayhsa04151:PI3K-Akt signaling pathway
B cell receptor signaling pathway
Epstein-Barr virus infection
Primary immunodeficiency
NetPath Pathway IL-7 Signaling Pathway
PANTHER Pathway B cell activationP00010:B cell activation
Pathway Interaction Database BCR signaling pathwaybcr_5pathway:BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-1257604:PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways B Cell Receptor Signaling PathwayWP2806:Human Complement System
Signaling by the B Cell Receptor (BCR)
PIP3 activates AKT signaling
B Cell Receptor Signaling Pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 548715Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027936)