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About
Drug Information
Drug General Information
Drug ID
D0AJ7H
Drug Name
TG-2001
Synonyms
TG-2001; Vero-IL-2, Transgene; gene therapy (interleukin-2, melanoma/mesothelioma), Transgene
Indication
Unspecified
Investigative
[
1560316
]
Target and Pathway
Target(s)
Interleukin-2
Target Info
Modulator
KEGG Pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infection
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
Graft-versus-host disease
NetPath Pathway
IL-7 Signaling Pathway
TCR Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database
IL27-mediated signaling events
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
SHP2 signaling
Regulation of Telomerase
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
AP-1 transcription factor network
IL23-mediated signaling events
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in naï
IL12 signaling mediated by STAT4
Reactome
GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways
Cytokines and Inflammatory Response
IL-2 Signaling Pathway
Inflammatory Response Pathway
Aryl Hydrocarbon Receptor Pathway
Interleukin-2 signaling
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Corticotropin-releasing hormone
Allograft Rejection
Arylhydrocarbon receptor (AhR) signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Folate Metabolism
IL-5 Signaling Pathway
References
Ref 1560316
Immunotherapy of metastatic melanoma by intratumoral injections of Vero cells producing human IL-2: phase II randomized study comparing two dose levels.
