Details of Disease

Disease Name

Renal failure

Disease Class

GB60-GB6Z: Kidney failure

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DIS070UC: Renal failure

ICD-11

ICD-11: GB60-GB6Z

Disease Identifiers

MONDO ID

MONDO_0001106

MESH ID

D051437

UMLS CUI

C0035078

MedGen ID

11177

SNOMED CT ID

42399005

General Information of Disease (ID: DIS070UC)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Mannitol	DMSCDY9	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bovine alkaline phosphatase	DM976KP	Phase 2	NA	[2]
Recombinant human hepatocyte growth factor	DMQKCUU	Phase 1	NA	[3]
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This Disease is Treated as An Indication in 5 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ilepatril	DMTR50E	Discontinued in Phase 2/3	NA	[4]
FK-453	DMH3DXY	Discontinued in Phase 2	Small molecular drug	[5]
PALOSURAN	DMWCLZ6	Discontinued in Phase 2	Small molecular drug	[6]
TAK-044	DMBQ87R	Discontinued in Phase 2	Small molecular drug	[7]
PF-4967544	DME97LB	Discontinued in Phase 1	NA	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016080.
2	The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury. Nephron Clin Pract. 2014;127(1-4):144-8.
3	Clinical pipeline report, company report or official report of Kringle pharma.
4	Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5606).
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3516).
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3913).
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031546)