General Information of Disease (ID: DIS0C4XI)

Disease Name Chronic leukemia
Synonyms adult chronic leukemia; adult chronic leukaemia; CML; CLL; leukemia (disease), chronic; leukaemia (disease), chronic; chronic leukemia (disease); chronic leukemia; chronic leukaemia (disease)
Definition
A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia.
Disease Hierarchy
DISNAKFL: Leukemia
DIS0C4XI: Chronic leukemia
Disease Identifiers
MONDO ID
MONDO_0001014
UMLS CUI
C1279296
MedGen ID
220905
HPO ID
HP:0005558
SNOMED CT ID
2557004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
TNR OTVJGAFN Limited Genetic Variation [1]
BCR OTCN76C1 Strong Biomarker [2]
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References

1 TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia.Ann Hum Genet. 2004 Jul;68(Pt 4):362-6. doi: 10.1046/j.1529-8817.2004.00101.x.
2 NF-B pathways in hematological malignancies.Cell Mol Life Sci. 2014 Jun;71(11):2083-102. doi: 10.1007/s00018-013-1545-4. Epub 2014 Jan 14.