General Information of Disease (ID: DISNAKFL)

Disease Name Leukemia
Synonyms leukaemia NOS; leukemia, disease; leukemia, malignant; blood (leukemia); leukemia (disease); leukemias, general; leukaemia (disease); leukemia; leukemias
Definition
A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.
Disease Hierarchy
DISCDP7W: Haematological malignancy
DISNAKFL: Leukemia
Disease Identifiers
MONDO ID
MONDO_0005059
MESH ID
D007938
UMLS CUI
C0023418
MedGen ID
9725
HPO ID
HP:0001909
SNOMED CT ID
1162768007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 33 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aldesleukin DM4YMIS Approved NA [1]
Alemtuzumab DMZL3IV Approved Antibody [2]
Arsenic trioxide DM61TA4 Approved Small molecular drug [3]
Azacitidine DMTA5OE Approved Small molecular drug [4]
Bortezomib DMNO38U Approved Small molecular drug [5]
Busulfan DMXYJ9C Approved Small molecular drug [6]
Clofarabine DMCVJ86 Approved Small molecular drug [7]
Cyproheptadine DM92AH3 Approved Small molecular drug [8]
Dasatinib DMJV2EK Approved Small molecular drug [9]
Daunorubicin DMQUSBT Approved Small molecular drug [10]
Doxorubicin DMVP5YE Approved Small molecular drug [11]
Everolimus DM8X2EH Approved Small molecular drug [12]
Gemcitabine DMSE3I7 Approved Small molecular drug [13]
Idarubicin DMM0XGL Approved Small molecular drug [14]
Imatinib DM7RJXL Approved Small molecular drug [15]
Lenalidomide DM6Q7U4 Approved Small molecular drug [16]
Melphalan DMOLNHF Approved Small molecular drug [17]
Methotrexate DM2TEOL Approved Small molecular drug [18]
Methylprednisolone DM4BDON Approved Small molecular drug [19]
Mitoxantrone DMM39BF Approved Small molecular drug [20]
Mycophenolic acid DMRBMAU Approved NA [21]
Omacetaxine mepesuccinate DMPU2WX Approved Small molecular drug [22]
Pegaspargase DM2S26S Approved NA [23]
Peginterferon alfa-2a DMJI3BA Approved NA [24]
Peginterferon alfa-2b DMAP58Y Approved NA [25]
Pentostatin DM0HXDS Approved Small molecular drug [26]
Prednisolone DMQ8FR2 Approved Small molecular drug [27]
Propofol DMB4OLE Approved Small molecular drug [28]
Rituximab DM1YVZT Approved Antibody [29]
Tacrolimus DMZ7XNQ Approved Small molecular drug [30]
Thalidomide DM70BU5 Approved Small molecular drug [31]
Thiotepa DMIZKOP Approved Small molecular drug [32]
Vincristine DMINOX3 Approved Small molecular drug [33]
------------------------------------------------------------------------------------
⏷ Show the Full List of 33 Drug(s)
This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial
Drug Name Drug ID Highest Status Drug Type REF
Cyclosporin A DMUYKBZ Phase 2 Trial Small molecular drug [34]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CHOLINE DM5D9YK Investigative Small molecular drug [35]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 522 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AICDA TTKRTP6 Limited Genetic Variation [36]
AKR1B1 TTFBNVI Limited Biomarker [37]
ANXA8 TTSW16P Limited Altered Expression [38]
ASRGL1 TT4WT91 Limited Genetic Variation [39]
AURKB TT9RTBL Limited Altered Expression [40]
BCL2A1 TTGT9C7 Limited Biomarker [41]
BCL2L1 TTRE6AX Limited Altered Expression [42]
BRAF TT0EOB8 Limited Genetic Variation [43]
CASP5 TTWR48J Limited Genetic Variation [44]
CASR TTBUYHA Limited Biomarker [45]
CCNA2 TTAMQ62 Limited Altered Expression [46]
CCR7 TT2GIDQ Limited Biomarker [47]
CD22 TTM6QSK Limited Biomarker [48]
CD28 TTQ13FT Limited Biomarker [49]
CD33 TTJVYO3 Limited Biomarker [50]
CD5 TTEGYK1 Limited Altered Expression [51]
CD52 TTQT5S9 Limited Biomarker [52]
CD80 TT89Z17 Limited Altered Expression [53]
CD9 TTZEIBV Limited Biomarker [54]
CDKN1A TT9GUW0 Limited Posttranslational Modification [55]
CEBPA TT5LWG1 Limited Genetic Variation [56]
CES1 TTMF541 Limited Biomarker [57]
CFLAR TTJZQYH Limited Biomarker [58]
CFTR TTRLZHP Limited Altered Expression [59]
CHEK1 TTTU902 Limited Biomarker [60]
CLEC12A TT70N8V Limited Altered Expression [61]
CNTN2 TT2Z1WB Limited Genetic Variation [62]
CRYZ TTP6UO8 Limited Altered Expression [63]
CSPG4 TT7MYXI Limited Biomarker [64]
CXCL12 TT4UGTF Limited Biomarker [65]
CXCR4 TTBID49 Limited Biomarker [65]
CYBB TT5T8MR Limited Biomarker [66]
CYP1B1 TTI84H7 Limited Altered Expression [67]
DCK TTJOCE4 Limited Altered Expression [68]
DFFB TT2SRE0 Limited Genetic Variation [69]
DGKA TTGL8F0 Limited Biomarker [70]
DICER1 TTTEOPU Limited Altered Expression [71]
DLL4 TTV23LH Limited Biomarker [72]
DNMT3A TTJUALD Limited Biomarker [73]
DOT1L TTSZ8T1 Limited Altered Expression [74]
EBI3 TTJF68X Limited Biomarker [75]
EGLN1 TT9ISBX Limited Altered Expression [76]
EIF2AK2 TTXEZJ4 Limited Biomarker [77]
ERN1 TTKIAT3 Limited Genetic Variation [78]
EZH1 TTNJA0C Limited Posttranslational Modification [79]
EZH2 TT9MZCQ Limited Genetic Variation [80]
FCGR3A TTIFOC0 Limited Biomarker [81]
FDXR TT3W4IX Limited Biomarker [37]
FLT4 TTDCBX5 Limited Biomarker [82]
FOXM1 TTD3KOX Limited Biomarker [83]
GEM TTAZF9M Limited Genetic Variation [84]
GSTO1 TTWO3SH Limited Biomarker [85]
HAX1 TT21BYA Limited Genetic Variation [86]
HDAC1 TT6R7JZ Limited Biomarker [87]
HNRNPA1 TTPJ9XK Limited Biomarker [88]
HP TTLC8E1 Limited Biomarker [89]
IDH1 TTV2A1R Limited Genetic Variation [90]
IL15 TTJFA35 Limited Biomarker [91]
IL5 TTPREZD Limited Altered Expression [92]
KAT6A TT6O1J0 Limited Genetic Variation [93]
KDM1A TTNR0UQ Limited Biomarker [94]
KDR TTUTJGQ Limited Genetic Variation [95]
KIT TTX41N9 Limited Genetic Variation [96]
KLK3 TTS78AZ Limited Biomarker [97]
LAIR1 TTSI7A8 Limited Biomarker [98]
LAMP1 TTC214J Limited Altered Expression [99]
LAMP2 TTULDG7 Limited Biomarker [100]
LIFR TTID542 Limited Altered Expression [101]
LONP1 TTM1VPZ Limited Biomarker [102]
MAP2K1 TTIDAPM Limited Biomarker [103]
MGMT TTJ8DV7 Limited Genetic Variation [104]
MIA TT5HNVS Limited Biomarker [105]
MLH1 TTISG27 Limited Genetic Variation [106]
MME TT5TKPM Limited Altered Expression [107]
MSLN TT4RXME Limited Biomarker [108]
MYB TT8V13P Limited Altered Expression [109]
MYCBP TTVW4XU Limited Biomarker [110]
MYCN TT9JBY5 Limited Altered Expression [111]
MYD88 TTB6Q2O Limited Genetic Variation [112]
NAMPT TTD1WIG Limited Biomarker [113]
NCL TTK1V5Q Limited Biomarker [114]
NEDD8 TTNDC4K Limited Biomarker [115]
NOTCH3 TTVX7IA Limited Biomarker [116]
NR1I3 TTRANFM Limited Biomarker [45]
NR4A1 TTMXE2Q Limited Biomarker [117]
NRP2 TTRXUVC Limited Biomarker [118]
ODC1 TTUMGNO Limited Altered Expression [119]
OSM TTIVXSE Limited Biomarker [120]
PAX5 TTA4REJ Limited Biomarker [121]
PIM1 TTTN5QW Limited Biomarker [102]
PIN1 TTJNTSI Limited Altered Expression [94]
PMEL TT8MK59 Limited Biomarker [122]
PML TTLH9NY Limited Biomarker [123]
PRG4 TTSKF4V Limited Biomarker [124]
PRKAR1A TTNAHEX Limited Biomarker [45]
PRMT5 TTR1D7X Limited Biomarker [125]
PTK7 TTXH2ZN Limited Biomarker [126]
PVRIG TTOGCNT Limited Altered Expression [127]
RARA TTW38KT Limited Genetic Variation [128]
RNF6 TT4S09X Limited Biomarker [129]
ROCK1 TTZN7RP Limited Biomarker [130]
ROS1 TTSZ6Y3 Limited Biomarker [131]
RPS6KA3 TTUM2ZR Limited Biomarker [132]
SELE TT1PL7M Limited Biomarker [133]
SELL TT2IYXF Limited Biomarker [134]
SF3B1 TTL2WUI Limited Genetic Variation [135]
TCL1A TTUKRDV Limited Genetic Variation [136]
TEK TT9VGXW Limited Biomarker [137]
THPO TTCG5PE Limited Biomarker [138]
TMBIM6 TT7QSMG Limited Biomarker [139]
TNFRSF10B TTW20TU Limited Biomarker [140]
TNFSF13B TTWMIDN Limited Biomarker [141]
TRPM5 TT1N8F3 Limited Genetic Variation [142]
UGCG TTPHEX3 Limited Altered Expression [143]
VEGFD TTOM5H4 Limited Biomarker [144]
VTCN1 TTCK85E Limited Biomarker [145]
ZEB2 TTT2WK4 Limited Biomarker [146]
ZNF224 TT1CDXL Limited Biomarker [147]
RAC1 TT2M9CG Disputed Biomarker [148]
TYRO3 TTIEMFN Disputed Altered Expression [149]
ABL2 TT1A6HL moderate Biomarker [150]
ACVRL1 TTGYPTC moderate Biomarker [151]
AIMP2 TTXWHGF moderate Biomarker [152]
ALPI TTHYMUV moderate Biomarker [153]
AR TTKPW01 moderate Biomarker [154]
ATF4 TTQCKWT moderate Biomarker [155]
ATR TT8ZYBQ moderate Biomarker [156]
BAK1 TTFM7V0 moderate Biomarker [157]
BAP1 TT47RXJ moderate Biomarker [158]
BCL2L2 TTQ79W8 moderate Biomarker [159]
C5AR1 TTHXFA1 moderate Altered Expression [160]
CALR TTUZ7OA moderate Genetic Variation [161]
CDK1 TTH6V3D moderate Biomarker [162]
CRK TTFEUYR moderate Biomarker [152]
CRLF2 TTRMZ0N moderate Genetic Variation [163]
CRTC2 TTFWETR moderate Biomarker [164]
CSF3R TTC70AJ moderate Biomarker [165]
CTSG TTQAJF1 moderate Biomarker [166]
CYP24A1 TT82UI1 moderate Biomarker [167]
DCLK1 TTOHTCY moderate Biomarker [168]
DHODH TTLVP78 moderate Altered Expression [169]
EHMT2 TTS6RZT moderate Biomarker [170]
EIF2AK4 TT9U4EP moderate Altered Expression [171]
ELANE TTPLTSQ moderate Altered Expression [172]
EPOR TTAUX24 moderate Genetic Variation [173]
FBXW7 TT29KY7 moderate Biomarker [174]
FFAR2 TT0FYAN moderate Altered Expression [175]
FGF1 TTMY81X moderate Biomarker [176]
FTO TTFW3BT moderate Biomarker [177]
GJB7 TTZ7POK moderate Biomarker [178]
GPRC6A TTI1PRE moderate Altered Expression [179]
GRIA3 TT82EZV moderate Altered Expression [180]
HPGDS TTCYE56 moderate Genetic Variation [181]
IAPP TTHN8EM moderate Biomarker [153]
IL2 TTF89GD moderate Biomarker [91]
IL24 TT1EPXZ moderate Biomarker [182]
ILK TT7ALZG moderate Biomarker [183]
ITGAM TTB69FJ moderate Biomarker [184]
JAK1 TT6DM01 moderate Altered Expression [185]
KMT5B TTJGV7F moderate Biomarker [186]
LGALS3 TTFPQV7 moderate Biomarker [187]
LPAR3 TTE2YJR moderate Altered Expression [179]
LTB4R TTN53ZF moderate Altered Expression [179]
LY9 TTZCL1U moderate Biomarker [188]
MCM7 TT1RM3F moderate Altered Expression [189]
MPL TTIHYA4 moderate Biomarker [190]
MRGPRX1 TTIX6PK moderate Altered Expression [179]
NRP1 TTIPJCB moderate Biomarker [191]
NSD1 TTTSJ3H moderate Biomarker [192]
OXER1 TT7WBSV moderate Altered Expression [179]
PDGFRA TT8FYO9 moderate Biomarker [193]
PGD TTZ3IFB moderate Biomarker [194]
PHGDH TT8DRCK moderate Biomarker [195]
PIM3 TTCGOIN moderate Altered Expression [196]
PLK1 TTH4IP0 moderate Biomarker [197]
PPM1D TTENJAB moderate Biomarker [198]
PRAME TTPH7T0 moderate Biomarker [199]
PTPN11 TT7WUAV moderate Genetic Variation [200]
PTPRC TTUS45N moderate Altered Expression [184]
RAB9A TT958S6 moderate Biomarker [201]
ROR2 TTUDPCI moderate Biomarker [202]
RPL15 TTQRVC9 moderate Biomarker [203]
RPSA TTLUW5B moderate Altered Expression [204]
RTN4R TTVRZUO moderate Biomarker [205]
RUNX3 TTKCVO7 moderate Biomarker [206]
S100A8 TT4AF6N moderate Biomarker [207]
SIRT2 TTLKF5M moderate Biomarker [208]
SLC9A1 TTGSEFH moderate Biomarker [209]
SMYD3 TTKLJYX moderate Biomarker [210]
SSRP1 TTETDKQ moderate Biomarker [211]
ST8SIA4 TTDP8YM moderate Altered Expression [212]
TK1 TTP3QRF moderate Altered Expression [213]
TNFRSF18 TTG6LA7 moderate Biomarker [214]
TRIM28 TTQ2BKV moderate Biomarker [215]
USP10 TT5IH09 moderate Biomarker [216]
VDAC1 TTAMKGB moderate Biomarker [217]
ABCB4 TTJUXV6 Strong Altered Expression [218]
ABCC3 TTVLG21 Strong Biomarker [219]
ABCC4 TTUEAFL Strong Genetic Variation [220]
ABCC8 TTP835K Strong Biomarker [221]
ACHE TT1RS9F Strong Altered Expression [222]
ADAM17 TT6AZXG Strong Biomarker [223]
ADAMTS1 TTS2TEI Strong Biomarker [224]
AKR1C3 TT5ZWB6 Strong Biomarker [225]
ANK1 TTKFPMH Strong Genetic Variation [173]
ANXA2 TT4YANI Strong Posttranslational Modification [226]
AOX1 TT3MOS2 Strong Genetic Variation [227]
APCS TTB7VAT Strong Altered Expression [228]
AQP9 TTQEI32 Strong Therapeutic [229]
ASPA TT6TLZP Strong Biomarker [230]
ATIC TT9NVXQ Strong Biomarker [231]
ATM TTKBM7V Strong Biomarker [232]
AURKA TTPS3C0 Strong Biomarker [233]
AXL TTZPY6J Strong Biomarker [234]
BCAT1 TTES57P Strong Altered Expression [235]
BCHE TT3MSAO Strong Biomarker [236]
BCL11A TTR61MW Strong Altered Expression [237]
BCL6 TTC9YX5 Strong Altered Expression [238]
BIRC3 TTAIWZN Strong Biomarker [239]
BMX TTN2I9E Strong Altered Expression [240]
BPHL TTTZ3EU Strong Biomarker [241]
BRD4 TTSRAOU Strong Biomarker [242]
BRIP1 TTZV7LJ Strong Biomarker [243]
BSG TT5UJWD Strong Biomarker [244]
BST2 TT90BJT Strong Biomarker [245]
BTG1 TTL7N2W Strong Altered Expression [246]
BTK TTGM6VW Strong Biomarker [247]
BTLA TTER58P Strong Genetic Variation [248]
BUB1 TT78309 Strong Altered Expression [249]
CA2 TTANPDJ Strong Genetic Variation [250]
CASP10 TTX5HEK Strong Genetic Variation [251]
CASP2 TT12VNG Strong Biomarker [252]
CBR1 TTVG0SN Strong Biomarker [253]
CBX7 TTBN3HC Strong Biomarker [254]
CCKBR TTVFO0U Strong Biomarker [255]
CCL3 TT8I4WB Strong Biomarker [256]
CCNB1 TT9P6OW Strong Altered Expression [257]
CCND1 TTFCJ7S Strong Altered Expression [258]
CCND3 TT1JXNR Strong Altered Expression [259]
CCNE1 TTCEJ4F Strong Altered Expression [260]
CCNE2 TTLDRGX Strong Altered Expression [249]
CCR5 TTJIH8Q Strong Biomarker [65]
CCR6 TTFDB30 Strong Biomarker [261]
CCR9 TTIPS8B Strong Biomarker [262]
CD1A TTBGTFN Strong Altered Expression [263]
CD200 TT0BE68 Strong Altered Expression [264]
CD27 TTDO1MV Strong Genetic Variation [265]
CD37 TTFCW29 Strong Biomarker [266]
CD3G TTV3XPL Strong Genetic Variation [267]
CD40LG TTIJP3Q Strong Biomarker [268]
CD46 TTMS7DF Strong Biomarker [269]
CD70 TTNCIE0 Strong Biomarker [270]
CD79B TTBN5I7 Strong Biomarker [271]
CDA TTQ12RK Strong Biomarker [272]
CDK2 TT7HF4W Strong Biomarker [273]
CDK6 TTO0FDJ Strong Biomarker [274]
CDK8 TTBJR4L Strong Biomarker [275]
CDK9 TT1LVF2 Strong Biomarker [276]
CEBPB TTUI35N Strong Altered Expression [277]
CHEK2 TT9ABMF Strong Posttranslational Modification [278]
CLEC4C TT7YT06 Strong Biomarker [279]
CNTF TTGEM5Q Strong Biomarker [280]
COPS5 TTSTNJR Strong Biomarker [281]
CR1 TTEA8OW Strong Altered Expression [282]
CR2 TT0HUN7 Strong Altered Expression [283]
CREB1 TTH4AN3 Strong Genetic Variation [284]
CREBBP TTFRCTK Strong Biomarker [285]
CSE1L TTTRULD Strong Biomarker [286]
CSF1 TT0IQER Strong Biomarker [287]
CSF1R TT7MRDV Strong Altered Expression [288]
CSF2RB TTPYS82 Strong Altered Expression [289]
CSNK2A1 TTER6YH Strong Biomarker [290]
CSNK2A2 TT7GR5W Strong Biomarker [290]
CTF1 TTXGTZU Strong Biomarker [291]
CXCR1 TTMWT8Z Strong Biomarker [292]
CYP3A5 TTHS0OK Strong Genetic Variation [293]
DHFR TTYZVDJ Strong Altered Expression [294]
DNASE1 TTYWGOJ Strong Biomarker [295]
DNMT3B TT6VZ78 Strong Biomarker [296]
DUSP1 TTG8HIM Strong Altered Expression [297]
EBP TT4VQZX Strong Biomarker [298]
EIF4E TTZGCP6 Strong Biomarker [299]
EIF5A TTIVCNR Strong Biomarker [300]
EP300 TTGH73N Strong Biomarker [301]
EPHA3 TTHS2LR Strong Biomarker [302]
ERF TTGXULC Strong Altered Expression [303]
ESR1 TTZAYWL Strong Biomarker [304]
F2R TTL935N Strong Altered Expression [305]
F2RL3 TTD0652 Strong Altered Expression [306]
F8 TT1290U Strong Biomarker [307]
F9 TTFEZ5Q Strong Biomarker [308]
FANCA TTV5HJS Strong Biomarker [243]
FANCF TTNZKFJ Strong Biomarker [243]
FASLG TTO7014 Strong Biomarker [309]
FCER2 TTCH6MU Strong Biomarker [310]
FCGR2B TT5RWKQ Strong Biomarker [311]
FCGRT TTKLPHO Strong Biomarker [312]
FES TTLBY21 Strong Biomarker [313]
FGF4 TTCEKVZ Strong Genetic Variation [314]
FMNL1 TTW20PQ Strong Biomarker [315]
FOXC1 TTNT3YA Strong Biomarker [316]
FPR1 TT5Y4EM Strong Altered Expression [317]
FUT3 TTUPAD7 Strong Altered Expression [318]
FUT4 TTNV1KZ Strong Biomarker [319]
G6PD TTKN8W0 Strong Biomarker [320]
GGH TTZJRL0 Strong Altered Expression [321]
GPER1 TTDSB34 Strong Altered Expression [149]
GPR137 TTATO6X Strong Altered Expression [322]
GRB2 TTEYRJ9 Strong Biomarker [323]
GSTA1 TT4P8DE Strong Biomarker [324]
GZMB TTKEPHX Strong Altered Expression [325]
HBA2 TTQO71U Strong Altered Expression [326]
HDAC7 TTMUEK1 Strong Altered Expression [327]
HDAC9 TT8M4E1 Strong Biomarker [328]
HDC TTV9GOF Strong Biomarker [329]
HEXIM1 TTFOKAH Strong Biomarker [330]
HMBS TTT0HW3 Strong Genetic Variation [267]
HMGA1 TTBA219 Strong Altered Expression [331]
HMGB2 TTA78JQ Strong Biomarker [332]
HNF1A TT01M3K Strong Biomarker [333]
HOXA11 TTEX4ZA Strong Genetic Variation [334]
HOXA13 TTN26OM Strong Genetic Variation [335]
HOXA5 TTXSVQP Strong Biomarker [336]
HOXA7 TTMRE4Q Strong Altered Expression [337]
HOXB13 TTZ6I58 Strong Genetic Variation [338]
HSD11B2 TT9H85R Strong Altered Expression [339]
HSF1 TTN6STZ Strong Biomarker [340]
HSP90AA1 TT78R5H Strong Altered Expression [341]
HSP90AB1 TTH5YN2 Strong Genetic Variation [342]
HSPB8 TTY0OJN Strong Altered Expression [343]
HTT TTIWZ0O Strong Biomarker [344]
ID1 TTBXVDE Strong Biomarker [345]
IFNAR1 TTSYFMA Strong Genetic Variation [346]
IGFBP7 TTUQ01B Strong Biomarker [347]
IKZF3 TTCZVFZ Strong Genetic Variation [348]
IL11 TTGUYTR Strong Biomarker [280]
IL15RA TTGN89I Strong Altered Expression [53]
IL17F TT2B6PS Strong Biomarker [349]
IL1R1 TTWOTEA Strong Altered Expression [350]
IL1RL1 TT4GZA4 Strong Genetic Variation [351]
IL2RB TT9721Y Strong Biomarker [352]
IL3RA TTENHJ0 Strong Altered Expression [353]
IL7 TT8FRMO Strong Biomarker [354]
IL7R TTAWI51 Strong Altered Expression [355]
INPP5D TTTP2Z1 Strong Genetic Variation [356]
IRAK1 TTXAJWN Strong Biomarker [357]
IRF1 TT4TU3L Strong Genetic Variation [358]
IRF8 TTHUBNK Strong Biomarker [359]
ITGA6 TT165T3 Strong Altered Expression [360]
JAK3 TTT7PJU Strong Genetic Variation [361]
JMJD1C TTBISK4 Strong Biomarker [362]
KAT6B TTH4VJL Strong Genetic Variation [363]
KCNH1 TT9XKUC Strong Altered Expression [364]
KCNH3 TTZ4MTQ Strong Biomarker [365]
KDM4C TTV8CRH Strong Biomarker [366]
KDM5A TTIG67W Strong Biomarker [367]
KDM5B TTCLI75 Strong Altered Expression [368]
KDM6B TTDIJUQ Strong Biomarker [369]
KIR2DS1 TTVWAGF Strong Genetic Variation [370]
KIR3DL2 TTQH3N0 Strong Genetic Variation [370]
KLRC1 TTC4IMS Strong Biomarker [371]
KLRK1 TTLRN4A Strong Biomarker [108]
KSR1 TTHL1TV Strong Biomarker [372]
LAG3 TTNVXAW Strong Biomarker [373]
LAMB3 TT2WOUQ Strong Altered Expression [374]
LCK TT860QF Strong Biomarker [375]
LIF TTGZ5WN Strong Biomarker [376]
LIN28A TTO50LN Strong Biomarker [377]
LMO2 TTFX379 Strong Biomarker [378]
LRP6 TTSXOWE Strong Posttranslational Modification [379]
LTA TTP73TM Strong Genetic Variation [380]
LTB4R2 TTVJX54 Strong Biomarker [381]
LTF TTSZDQU Strong Genetic Variation [382]
LTK TT1JZG6 Strong Altered Expression [383]
LYN TT1RWNJ Strong Altered Expression [384]
LYZ TTAOZBW Strong Biomarker [385]
MAGEA1 TT63M7Q Strong Altered Expression [386]
MAGEA3 TTWSKHD Strong Altered Expression [387]
MAP2K2 TT8H9GB Strong Altered Expression [388]
MAP2K5 TTV3O87 Strong Biomarker [389]
MAP2K7 TT6QY3J Strong Biomarker [390]
MAPK11 TT73U6C Strong Biomarker [391]
MAPK7 TTU6FSC Strong Biomarker [389]
MAPK8 TT0K6EO Strong Biomarker [392]
MAPK9 TT3IVG2 Strong Biomarker [393]
MARK2 TTAJ45Y Strong Biomarker [394]
MCOLN1 TT9XBVO Strong Biomarker [349]
MDM2 TT9TE0O Strong Altered Expression [395]
MERTK TTO7LKR Strong Biomarker [396]
MSH2 TTCAWRT Strong Altered Expression [397]
MSI2 TTTXQF6 Strong Biomarker [398]
MSR1 TT2TDH9 Strong Biomarker [399]
MST1R TTBQ3OC Strong Altered Expression [400]
MUSK TT6SA0X Strong Biomarker [401]
NCOA3 TT124R0 Strong Biomarker [402]
NCR1 TTQNRJM Strong Biomarker [403]
NEDD9 TT1UREA Strong Altered Expression [404]
NGFR TTEDJN4 Strong Altered Expression [405]
NME1 TTDY8JH Strong Biomarker [406]
NOTCH4 TTXDIK2 Strong Biomarker [407]
NPEPPS TT371QC Strong Biomarker [408]
NR1H2 TTXA6PH Strong Altered Expression [409]
NR4A3 TTJQB49 Strong Biomarker [410]
NR5A2 TTAU3SY Strong Altered Expression [411]
P2RY1 TTA93TL Strong Biomarker [412]
P2RY8 TT84EWY Strong Altered Expression [413]
PADI4 TTQHAXM Strong Genetic Variation [414]
PARG TT39J16 Strong Biomarker [241]
PAWR TT3I4WV Strong Altered Expression [306]
PBK TTMY6BZ Strong Altered Expression [415]
PDGFB TTQA6SX Strong Altered Expression [416]
PDGFRB TTI7421 Strong Altered Expression [417]
PECAM1 TT4EZB2 Strong Genetic Variation [418]
PF4 TTSG7Q5 Strong Biomarker [419]
PHB TT6U071 Strong Altered Expression [420]
PHF8 TT81PFE Strong Biomarker [421]
PIM2 TT69J2Z Strong Biomarker [422]
PLA2R1 TTHKW7D Strong Posttranslational Modification [423]
PLCG1 TT6T4JI Strong Biomarker [424]
PLK4 TTGPNZQ Strong Biomarker [425]
PLN TTMCVJF Strong Biomarker [426]
PPIB TT6ZFQ4 Strong Biomarker [427]
PPP5C TTTW7FJ Strong Biomarker [428]
PRKCZ TTBSN0L Strong Biomarker [239]
PRMT1 TTVOJAI Strong Biomarker [429]
PRTN3 TT5MLC4 Strong Biomarker [430]
PSIP1 TTH9LDP Strong Biomarker [431]
PTAFR TTQL5VC Strong Biomarker [432]
PTEN TTXJ3W7 Strong Biomarker [433]
PTGER4 TT79WV3 Strong Altered Expression [434]
PTK2B TTTEFBV Strong Biomarker [354]
PTPN13 TT405FP Strong Altered Expression [435]
PTPN2 TTY8PUS Strong Biomarker [436]
QPCT TTJ7YTV Strong Biomarker [437]
RALBP1 TTVSRUA Strong Biomarker [438]
RARG TT1Q3IE Strong Genetic Variation [128]
REG3A TTL4H8N Strong Genetic Variation [439]
ROBO4 TT3S9TY Strong Altered Expression [440]
ROR1 TTDEJAU Strong Biomarker [441]
RORC TTGV6LY Strong Altered Expression [442]
RUNX2 TTD6SZ8 Strong Biomarker [443]
RXRA TT6PEUO Strong Biomarker [444]
S100A4 TTPR5SX Strong Biomarker [445]
S1PR5 TTDZCKV Strong Altered Expression [446]
SDC1 TTYDSVG Strong Altered Expression [447]
SELP TTE5VG0 Strong Biomarker [448]
SELPLG TTS5K8U Strong Biomarker [449]
SENP1 TTW9HY5 Strong Biomarker [450]
SEPTIN6 TTAGE7U Strong Biomarker [451]
SERPINC1 TT4QPUL Strong Altered Expression [452]
SETD2 TTPC3H4 Strong Biomarker [453]
SH3GL1 TTTYNAM Strong Biomarker [454]
SIRT6 TTUXYWF Strong Biomarker [455]
SLC22A1 TTM5Q4V Strong Biomarker [456]
SLC22A16 TTITAVR Strong Altered Expression [457]
SLC23A2 TTOP832 Strong Biomarker [458]
SLC29A1 TTLXAKE Strong Altered Expression [459]
SLC46A1 TTY8Z2E Strong Altered Expression [460]
SLC52A2 TT6TKEN Strong Biomarker [394]
SLIT2 TTDWK85 Strong Posttranslational Modification [461]
SMPD2 TTE5VI6 Strong Altered Expression [462]
SMYD2 TT7YJFO Strong Biomarker [463]
SNAP25 TTYQWA0 Strong Genetic Variation [464]
SOCS3 TTI0ME6 Strong Altered Expression [465]
SPHK1 TTOHFIY Strong Biomarker [466]
SPN TTOZAX0 Strong Biomarker [310]
SRC TT6PKBN Strong Biomarker [467]
SRPK1 TTU3WV6 Strong Biomarker [468]
SRPK2 TTCZEJ9 Strong Altered Expression [469]
STC1 TTDLUER Strong Biomarker [470]
STMN1 TT7W5OT Strong Altered Expression [471]
SUV39H1 TTUWQTK Strong Biomarker [472]
TERF1 TT1Y6J2 Strong Altered Expression [473]
TERF2 TT5XSLT Strong Biomarker [474]
TF TT8WXAV Strong Altered Expression [475]
THRB TTGER3L Strong Altered Expression [476]
TIE1 TTT4236 Strong Altered Expression [477]
TNFRSF10A TT5WLRX Strong Altered Expression [478]
TNFRSF12A TTKPS7V Strong Altered Expression [479]
TNFRSF13B TTL9OD4 Strong Biomarker [480]
TNFRSF17 TTZ3P4W Strong Biomarker [480]
TNFRSF8 TT2GM5R Strong Biomarker [481]
TNFRSF9 TTPW9LJ Strong Biomarker [482]
TNFSF13 TTOI1RM Strong Biomarker [483]
TNFSF4 TTBW580 Strong Biomarker [484]
TNK1 TTWS7I3 Strong Altered Expression [485]
TNK2 TTIET93 Strong Genetic Variation [486]
TOP1 TTGTQHC Strong Altered Expression [487]
TPT1 TT3PTB6 Strong Biomarker [488]
TRB TT84HCW Strong Biomarker [489]
TRBC1 TT1DHW2 Strong Biomarker [490]
TRPM7 TTFPVZO Strong Biomarker [491]
TRPV2 TTBECWA Strong Biomarker [492]
TRPV6 TTBK14N Strong Biomarker [493]
TSLP TTHMW3T Strong Altered Expression [494]
TUSC2 TTJ8O14 Strong Genetic Variation [439]
TYR TTULVH8 Strong Biomarker [495]
UBE2E2 TTXJEOF Strong Altered Expression [321]
USP7 TTXU3EQ Strong Biomarker [496]
WDR5 TT7OFWB Strong Biomarker [497]
WEE1 TTJFOAL Strong Biomarker [498]
WNT5A TTKG7F8 Strong Biomarker [499]
WNT7A TT8NARC Strong Altered Expression [500]
XIAP TTK3WBU Strong Biomarker [501]
XPO1 TTCJUR4 Strong Altered Expression [502]
ZAP70 TTUMHT8 Strong Altered Expression [503]
APEX1 TTHGL48 Definitive Biomarker [504]
BIRC2 TTQ5LRD Definitive Altered Expression [505]
BMP6 TT07RIB Definitive Posttranslational Modification [506]
CD47 TT28S46 Definitive Biomarker [507]
DDIT4 TTVEOY6 Definitive Biomarker [508]
DGKZ TTSBBXL Definitive Biomarker [509]
GRM3 TT8A9EF Definitive Altered Expression [180]
HIPK2 TTOB49C Definitive Genetic Variation [510]
KIR2DL1 TT4UXPE Definitive Biomarker [511]
OPRK1 TTQW87Y Definitive Biomarker [512]
PKM TT4LOT8 Definitive Biomarker [513]
RIPK1 TTVJHX8 Definitive Biomarker [438]
SLC5A6 TT61XTV Definitive Altered Expression [514]
TOP2A TTCGY2K Definitive Biomarker [487]
USP1 TTG9MT5 Definitive Biomarker [515]
WT1 TTZ8UT4 Definitive Altered Expression [516]
------------------------------------------------------------------------------------
⏷ Show the Full List of 522 DTT(s)
This Disease Is Related to 12 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCB5 DTKVEXO Limited Biomarker [517]
SLC5A8 DTE3TAW Limited Genetic Variation [518]
ATP7A DT0LT17 moderate Biomarker [519]
ABCC11 DTWN7FC Strong Biomarker [221]
ABCC6 DT582KR Strong Biomarker [316]
SLC22A4 DT2EG60 Strong Biomarker [520]
SLC25A20 DTQOUM4 Strong Genetic Variation [250]
SLC25A21 DT2UQYR Strong Posttranslational Modification [521]
SLC25A3 DTCRIWV Strong Biomarker [522]
SLC29A2 DTW78DQ Strong Biomarker [523]
SLC39A8 DTLPQGT Strong Biomarker [524]
SLCO6A1 DTIFXNS Definitive Genetic Variation [525]
------------------------------------------------------------------------------------
⏷ Show the Full List of 12 DTP(s)
This Disease Is Related to 22 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
FPGS DECWT2V Limited Genetic Variation [526]
NT5C2 DE1DOKJ Limited Genetic Variation [527]
TPMT DEFQ8VO Limited Genetic Variation [528]
ABO DESIA7R moderate Genetic Variation [529]
ALDH1A1 DE2JP1Y moderate Altered Expression [530]
ASNS DEXISVQ moderate Genetic Variation [531]
HPRT1 DEVXTP5 moderate Genetic Variation [532]
PARK7 DEPOVCH moderate Biomarker [533]
PON2 DEHJU7E moderate Altered Expression [534]
ACP3 DEDW5H6 Strong Biomarker [535]
AKR1C4 DEAJN47 Strong Biomarker [536]
APRT DE2MV1R Strong Biomarker [537]
CMPK1 DEMPH4I Strong Biomarker [538]
GGCT DEKW6PB Strong Biomarker [539]
HK1 DEDMAGE Strong Biomarker [513]
MTRR DE6NIY9 Strong Genetic Variation [540]
NAT1 DE7OAB3 Strong Altered Expression [541]
PER1 DE9HF0I Strong Posttranslational Modification [542]
PSAT1 DEBS17P Strong Biomarker [408]
SCLY DEH4TD6 Strong Biomarker [543]
SULT2A1 DE0P6LK Strong Genetic Variation [544]
THOP1 DE95LJC Strong Altered Expression [545]
------------------------------------------------------------------------------------
⏷ Show the Full List of 22 DME(s)
This Disease Is Related to 742 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ABI1 OT5H4M62 Limited Altered Expression [546]
ADD1 OTTF68DC Limited Biomarker [547]
AGFG2 OTXQZHCR Limited Genetic Variation [548]
AK6 OT84OHHP Limited Posttranslational Modification [549]
ALKBH1 OTADGU5D Limited Biomarker [550]
ANKRD26 OT2ENKKV Limited Genetic Variation [551]
APOBEC2 OT4CCS0Q Limited Altered Expression [552]
ARID2 OTIRJXWM Limited Biomarker [553]
ARID5B OTUQ4CQY Limited Genetic Variation [554]
ARR3 OTRZ00CH Limited Biomarker [45]
ARSH OTG0X9UQ Limited Biomarker [323]
ASPG OT5E2EKR Limited Biomarker [555]
ATG5 OT4T5SMS Limited Biomarker [230]
ATN1 OTNZFLKY Limited Biomarker [556]
BLNK OTSSPF6F Limited Altered Expression [557]
CALM2 OTNYA92F Limited Biomarker [558]
CBFB OTIAC6W4 Limited Altered Expression [559]
CBX2 OTOQ5WS4 Limited Biomarker [328]
CD226 OT4UG0KB Limited Altered Expression [127]
CD79A OTOJC8DV Limited Biomarker [560]
CEBPE OTKZA25M Limited Biomarker [561]
CEBPZ OT11BATG Limited Biomarker [562]
CENPM OTYK9KOX Limited Biomarker [563]
CIAPIN1 OTWS90F9 Limited Biomarker [564]
CIP2A OTVS2GXA Limited Biomarker [565]
CNTRL OTQI3VBA Limited Biomarker [566]
COBL OTTB4VFQ Limited Biomarker [567]
COX8A OTU0NR39 Limited Genetic Variation [568]
CXADR OT9ZP02A Limited Biomarker [45]
DCTN6 OTI8PIN9 Limited Biomarker [569]
DDX4 OTQOV093 Limited Altered Expression [570]
DNTT OTFSEF12 Limited Posttranslational Modification [571]
ELL OTCBN5LF Limited Altered Expression [572]
EMB OT67E3Q1 Limited Biomarker [573]
ERCC2 OT1C8HQ4 Limited Genetic Variation [574]
ESM1 OT331Y8V Limited Biomarker [575]
ETV5 OTE2OBM4 Limited Biomarker [576]
EXOSC5 OTADUQ7H Limited Altered Expression [577]
FAM168A OTDXQCS5 Limited Biomarker [578]
FBLIM1 OTFHXMON Limited Biomarker [579]
FCGR3B OTSLSPZG Limited Biomarker [81]
FRZB OTTO3DPY Limited Posttranslational Modification [580]
GADD45GIP1 OT4IZ4TP Limited Biomarker [581]
GDE1 OTU6FSBF Limited Biomarker [582]
GINS2 OT974IYI Limited Altered Expression [583]
GNB2 OT3JPRCQ Limited Genetic Variation [584]
GOPC OTRBGH71 Limited Biomarker [579]
GORASP1 OTQS91S7 Limited Posttranslational Modification [585]
GYPA OTABU4YV Limited Biomarker [586]
GYPB OTESHUIX Limited Genetic Variation [586]
GYPE OTBHAG6A Limited Genetic Variation [586]
HIC1 OTI9TWY4 Limited Genetic Variation [587]
HMMR OT4M0JTZ Limited Biomarker [588]
HNRNPDL OTB3BFCV Limited Biomarker [589]
HOXA10 OTB6GQ09 Limited Biomarker [590]
HOXA4 OTNVTQDT Limited Posttranslational Modification [591]
HOXB3 OT9UC5PE Limited Genetic Variation [173]
HOXD13 OTWSC8TF Limited Altered Expression [592]
IDH2 OTTQA4PB Limited Genetic Variation [593]
IFNA1 OTPMKY0L Limited Biomarker [594]
IKZF1 OTCW1FKL Limited Genetic Variation [554]
IL18R1 OT83XMPQ Limited Biomarker [75]
IL3 OT0CQ35N Limited Altered Expression [595]
INA OT1D33T4 Limited Biomarker [596]
KAT2A OTN0W2SW Limited Altered Expression [597]
KDM2B OTDMCVW7 Limited Biomarker [598]
KDM6A OTZM3MJJ Limited Biomarker [599]
KIR3DL1 OTPOSXFX Limited Genetic Variation [84]
KMT2B OTMMAZQX Limited Altered Expression [600]
KMT2C OTC59BCO Limited Genetic Variation [601]
KMT2D OTTVHCLY Limited Altered Expression [600]
KMT2E OTYOLNOG Limited Altered Expression [602]
LAMP5 OTC672RM Limited Biomarker [603]
MBD2 OTUQPP0R Limited Altered Expression [604]
MEN1 OTN6U6V0 Limited Biomarker [605]
MLIP OTMT7AII Limited Posttranslational Modification [549]
MLLT1 OT41UZU5 Limited Biomarker [606]
MNDA OTCTKR47 Limited Altered Expression [607]
MOS OTNMQPFJ Limited Biomarker [608]
MRPL58 OTPTWLZY Limited Biomarker [609]
MTX1 OTLSDNZO Limited Genetic Variation [610]
NF1 OTC29NHH Limited Altered Expression [611]
NLRP2 OTJA81JU Limited Genetic Variation [612]
NNAT OTNRLO7G Limited Posttranslational Modification [613]
NOL3 OT1K0L0D Limited Biomarker [614]
NUDC OT073JKX Limited Altered Expression [615]
NUDCD1 OT8DS3CX Limited Altered Expression [577]
NUDT21 OTZHKWAR Limited Biomarker [616]
NUP98 OTNT12G2 Limited Biomarker [617]
NUTM1 OTONYC08 Limited Biomarker [618]
OAZ1 OTPT0PKZ Limited Altered Expression [619]
OSCP1 OTZ4IFGJ Limited Biomarker [117]
PCM1 OTFM133C Limited Biomarker [620]
PFDN5 OTTKPTUP Limited Biomarker [110]
PICALM OTQVRPMQ Limited Biomarker [558]
PLAGL2 OT6AP4V2 Limited Altered Expression [621]
PSMD9 OT6Y5CC3 Limited Biomarker [569]
PVALB OTZW1WVQ Limited Biomarker [495]
RARS1 OTHPZ6JN Limited Biomarker [622]
RASSF7 OT0V4EIZ Limited Biomarker [623]
RB1 OT9VMY7B Limited Biomarker [624]
REG1A OTMHUH1D Limited Biomarker [522]
RERE OT3G4GBZ Limited Biomarker [625]
RGPD2 OTMUZ0HX Limited Genetic Variation [548]
RRAS OTBBF28C Limited Biomarker [626]
S100A16 OT3ERKQI Limited Biomarker [627]
SBDS OTHDCCIB Limited Genetic Variation [628]
SEL1L OTC0FB7T Limited Altered Expression [629]
SEPTIN11 OTX2O0ZX Limited Biomarker [630]
SERINC3 OTQ1LAJ1 Limited Biomarker [631]
SERINC5 OT3COPVF Limited Biomarker [631]
SETBP1 OTKGCOSR Limited Altered Expression [632]
SH2B2 OTEDHHDH Limited Biomarker [97]
SIGIRR OTNC3XFD Limited Biomarker [633]
SIGLEC1 OTNWSQA9 Limited Altered Expression [634]
SIRT7 OT5M4OT4 Limited Genetic Variation [635]
SLN OTERIU75 Limited Altered Expression [552]
SMARCA1 OT0Y6PTU Limited Biomarker [636]
SNAP91 OTE3EXWZ Limited Biomarker [558]
SP100 OTN8SD5W Limited Biomarker [637]
SPG7 OT8OY9ST Limited Biomarker [45]
SSBP2 OTYG1G80 Limited Biomarker [638]
STAT5A OTBSJGN3 Limited Altered Expression [639]
STAT5B OTZVPEBT Limited Biomarker [594]
SYNCRIP OTRNDZXB Limited Therapeutic [640]
SYT1 OTVTPOI6 Limited Posttranslational Modification [585]
TAL1 OTX4K6QZ Limited Biomarker [641]
TCF4 OTB9ASTK Limited Biomarker [642]
TCHP OTVDMHSY Limited Biomarker [643]
TCL1B OT4CSO39 Limited Genetic Variation [136]
TET2 OTKKT03T Limited Genetic Variation [644]
TFIP11 OT7NVSWU Limited Biomarker [645]
TICAM2 OTK7GIJ5 Limited Biomarker [569]
TLX1 OTVN0MNW Limited Biomarker [646]
TMED7 OTONO8E6 Limited Biomarker [569]
TNPO3 OTOT3HH0 Limited Biomarker [647]
TNR OTVJGAFN Limited Genetic Variation [648]
TP53BP2 OTOWJ2Y4 Limited Altered Expression [649]
TRIM13 OTQIUACB Limited Biomarker [45]
FBXW11 OT2A6RLR Disputed Biomarker [650]
LIN28B OTVWP0FN Disputed Biomarker [651]
MRGPRF OT74OZ2Z Disputed Biomarker [652]
NSD3 OT3677ZG Disputed Biomarker [653]
RBFOX2 OTXY1WVH Disputed Biomarker [652]
TNFSF9 OTV9L89D Disputed Altered Expression [654]
ACD OTC54EPO moderate Biomarker [655]
ADCY7 OTAWMGP3 moderate Biomarker [656]
AFF4 OTTL5Y8R moderate Biomarker [657]
AHSA1 OTC7AFHT moderate Biomarker [152]
ALPP OTZU4G9W moderate Biomarker [153]
ARHGEF1 OTXU4HBW moderate Biomarker [658]
ASH1L OTUT5NLJ moderate Biomarker [659]
ASXL2 OTNG4E2M moderate Genetic Variation [660]
ATXN1 OTQF0HNR moderate Biomarker [661]
BCAR1 OTKT2C2N moderate Altered Expression [662]
CCNG2 OTII38K2 moderate Altered Expression [663]
CD200R1 OT65Q9M6 moderate Biomarker [49]
CDC73 OT6JASZ1 moderate Biomarker [664]
CEMP1 OTUEH5X5 moderate Altered Expression [665]
CEP152 OTOKZR9B moderate Biomarker [666]
CGAS OTJYIXNB moderate Biomarker [667]
CH25H OT9S2BSW moderate Altered Expression [668]
CRISPLD2 OTVSFHTL moderate Biomarker [669]
DACT1 OT19Z704 moderate Biomarker [670]
DDX53 OTHK3EGZ moderate Biomarker [671]
DEFB1 OT5SV0E4 moderate Biomarker [672]
DPY30 OTLHCJ6C moderate Biomarker [89]
DVL1 OTD67RF1 moderate Biomarker [673]
DVL2 OTMNYNCM moderate Biomarker [673]
DYNLRB2 OT1G3HAF moderate Biomarker [674]
EFNB2 OT0DCUOM moderate Biomarker [675]
ERCC5 OTQAKFJM moderate Genetic Variation [574]
ERG OTOTX9VU moderate Biomarker [676]
ESCO2 OTJEMAQU moderate Biomarker [677]
FLT3LG OTU0YGC4 moderate Biomarker [678]
FUT1 OTODG57A moderate Biomarker [679]
GAS7 OT0M5TNY moderate Biomarker [680]
GATA5 OTO81B63 moderate Biomarker [681]
GNB1 OTLL7L74 moderate Genetic Variation [682]
GOLGA6A OTHU9MRX moderate Biomarker [683]
GPR151 OT7EACU6 moderate Altered Expression [179]
GRAP2 OTS5NIZ3 moderate Biomarker [152]
GRB10 OTCKXGRC moderate Biomarker [684]
HBZ OTMHGFSS moderate Biomarker [685]
HLA-DRB3 OT5PM9N7 moderate Genetic Variation [686]
HMGB3 OTCJ2EZY moderate Biomarker [211]
IBTK OTB2GM4G moderate Altered Expression [687]
IFIT3 OTPGHZB9 moderate Altered Expression [688]
INPP4B OTLROA7G moderate Biomarker [689]
JAM3 OTX0F9QL moderate Biomarker [690]
KLRF1 OTGHZ7FU moderate Biomarker [691]
KNL1 OT4Q3LHV moderate Biomarker [666]
LETMD1 OTZTZ4RD moderate Biomarker [692]
LGR6 OTPZ1PWR moderate Altered Expression [179]
LIG3 OT48SKET moderate Altered Expression [693]
LIG4 OT40DNXU moderate Altered Expression [694]
MAGT1 OTQSAV5C moderate Biomarker [153]
MARCHF7 OTG9SF10 moderate Altered Expression [695]
MARVELD2 OTKB96L5 moderate Altered Expression [222]
MFAP1 OTZN4FT3 moderate Biomarker [537]
MKRN2 OTDD1V3O moderate Altered Expression [696]
MLLT11 OTG5RVHC moderate Biomarker [697]
MRGPRX3 OTRKCCDS moderate Altered Expression [179]
MRGPRX4 OTOBHZVA moderate Altered Expression [179]
MTHFD2 OT1LQSGX moderate Biomarker [698]
MYCBP2 OTHODA1F moderate Biomarker [699]
MZF1 OTMVZCPW moderate Biomarker [700]
NDN OTYBYJ82 moderate Biomarker [701]
NECTIN2 OTIE0W6O moderate Altered Expression [702]
NKX2-3 OTF4IL5J moderate Biomarker [205]
NT5C1A OTS7UF36 moderate Genetic Variation [703]
NUDT15 OTX8SZOT moderate Genetic Variation [704]
OCLN OTSUTVWL moderate Altered Expression [705]
PAQR3 OTTKJ9Y4 moderate Altered Expression [706]
PCLAF OTMVIOUU moderate Biomarker [664]
PDP1 OT82RTMT moderate Posttranslational Modification [707]
PGBD5 OTP051G2 moderate Genetic Variation [708]
PHF23 OTVF5VZC moderate Biomarker [709]
PIK3R2 OTZSUQK5 moderate Altered Expression [710]
PKNOX1 OTUDMNHX moderate Biomarker [711]
PLCG2 OTGVC9MY moderate Biomarker [467]
POLDIP2 OT8SZSJ6 moderate Biomarker [152]
PPM1K OTNZ4N4E moderate Genetic Variation [712]
PRAM1 OTZN3DWD moderate Genetic Variation [713]
PRF1 OTFVXD7H moderate Genetic Variation [714]
RAB27A OT9SQRWY moderate Biomarker [715]
RALA OT734R7X moderate Biomarker [716]
RCBTB1 OTAYELI8 moderate Biomarker [683]
RNASE3 OTVE2XD1 moderate Biomarker [717]
RNF19A OTKWCV80 moderate Biomarker [152]
SEPTIN9 OT1VMRFQ moderate Biomarker [718]
SET OTGYYQJO moderate Biomarker [565]
SIGLEC10 OTD1WDQL moderate Altered Expression [719]
SIM2 OT0QWHK4 moderate Biomarker [720]
SLFN11 OTJWFPMY moderate Altered Expression [721]
SMARCA2 OTSGJ8SV moderate Genetic Variation [636]
SPRED1 OTKX7P8G moderate Biomarker [722]
STAG2 OTR6X1Q7 moderate Genetic Variation [723]
STING1 OTDAP4G0 moderate Biomarker [724]
STUB1 OTSUYI9A moderate Biomarker [725]
TCF7L1 OTTUTF0O moderate Biomarker [726]
TJP2 OTQUY6BV moderate Biomarker [727]
TMEM30A OTR6N5J2 moderate Biomarker [728]
TRIM25 OT35SG1R moderate Biomarker [729]
A1CF OTJBKFA1 Strong Biomarker [230]
A2ML1 OTWNUXIS Strong Genetic Variation [730]
A4GALT OTPX3UGY Strong Altered Expression [731]
ABHD2 OTCRUOCS Strong Altered Expression [732]
ABR OTZQK8JF Strong Altered Expression [148]
ACACA OT5CQPZY Strong Genetic Variation [733]
ACP1 OTJ9CKLU Strong Altered Expression [734]
ADA2 OTGCV24S Strong Genetic Variation [735]
ADAR OTQNOHR8 Strong Biomarker [736]
ADRM1 OTOU4EY6 Strong Altered Expression [737]
AFF1 OTT2C78E Strong Biomarker [738]
AFF3 OTR0705Z Strong Biomarker [739]
AHI1 OT8K2YWY Strong Biomarker [740]
AHRR OTSJ12W6 Strong Biomarker [741]
AKAP13 OTOZAR14 Strong Biomarker [742]
AMN OTS1TJXG Strong Genetic Variation [743]
ANKHD1 OTVYQ7ZL Strong Biomarker [744]
ANKS1B OT26DGM9 Strong Altered Expression [745]
ANP32B OT3SQMLU Strong Biomarker [746]
ANXA7 OTLMD0TK Strong Biomarker [747]
APAF1 OTJWIVY0 Strong Altered Expression [748]
APCDD1 OTV9AD0L Strong Biomarker [749]
APOBEC1 OTY8QX2R Strong Biomarker [750]
APOBEC3A OTYO6F5P Strong Biomarker [751]
APOBEC3B OTHLNI51 Strong Genetic Variation [752]
APOBEC3C OTPL0AI1 Strong Biomarker [753]
AQP8 OT99JKME Strong Biomarker [754]
ARAP1 OTINOJJ7 Strong Altered Expression [317]
ARHGEF12 OTM2D3LT Strong Biomarker [755]
ARID3A OTZZ4SFP Strong Altered Expression [756]
ARID4A OT1XKBZ0 Strong Biomarker [757]
ARID4B OTYLPILE Strong Biomarker [758]
ARIH2 OTJYJQJ8 Strong Biomarker [590]
ASAP1 OT4DLRYY Strong Genetic Variation [439]
ASAP2 OTGEXULW Strong Genetic Variation [439]
ASPM OTKXQMNA Strong Biomarker [230]
ASS1 OT4ZMG0Q Strong Altered Expression [759]
ASXL1 OTX931AW Strong Genetic Variation [760]
ATF7IP OTU6ZA7F Strong Biomarker [761]
ATG3 OT28VBVK Strong Altered Expression [762]
ATP2A3 OTFYDEES Strong Altered Expression [763]
ATP8A2 OTDZC2ZT Strong Biomarker [349]
ATRX OT77RSQW Strong Genetic Variation [764]
B3GAT1 OTXFP98E Strong Biomarker [765]
B4GALNT2 OT85V4QV Strong Biomarker [766]
B4GALT1 OTBCXEK7 Strong Biomarker [767]
BAALC OTUZSRVF Strong Altered Expression [768]
BACH2 OT17GS18 Strong Genetic Variation [769]
BAD OT63ERYM Strong Biomarker [239]
BAG1 OTRQNIA4 Strong Biomarker [770]
BCL11B OT8KKCVJ Strong Biomarker [771]
BCL3 OT1M5B95 Strong Biomarker [772]
BCOR OTG013AX Strong Biomarker [773]
BCORL1 OTPTFQN5 Strong Biomarker [774]
BEX1 OTBQIF0H Strong Altered Expression [775]
BEX2 OT4G5SIC Strong Altered Expression [776]
BLM OTEJOAJX Strong Biomarker [243]
BLZF1 OT5QD8FG Strong Biomarker [777]
BRI3BP OTWCFPRM Strong Altered Expression [778]
C16orf96 OTE0B1QV Strong Biomarker [517]
C4BPA OTHNH6Y8 Strong Biomarker [779]
CAB39L OTQEBL0W Strong Genetic Variation [780]
CAMK4 OT47RDGV Strong Altered Expression [781]
CAMLG OTTSRY39 Strong Altered Expression [782]
CBFA2T2 OTNOIB23 Strong Altered Expression [783]
CBFA2T3 OTOJ10S1 Strong Biomarker [784]
CCDC51 OTOJNHNA Strong Biomarker [785]
CCNA1 OTX4HD45 Strong Altered Expression [786]
CD1C OT4XINUJ Strong Biomarker [787]
CD244 OTSMR85N Strong Biomarker [569]
CD247 OT45FGUX Strong Biomarker [788]
CD48 OT83ZNPP Strong Biomarker [789]
CD82 OTH8MC64 Strong Biomarker [790]
CD8A OTDWQJXK Strong Biomarker [791]
CD8B OTMZ1T7J Strong Biomarker [791]
CD99 OTPUZ5DE Strong Biomarker [792]
CDC34 OTNBK390 Strong Altered Expression [793]
CDKN2D OT2TTZPZ Strong Biomarker [308]
CDX4 OTD1SQKM Strong Altered Expression [794]
CHAF1B OTOMK4KH Strong Altered Expression [795]
CHD1 OT9R9G0H Strong Genetic Variation [796]
CHD5 OTS5EVHH Strong Altered Expression [797]
CHGB OT7SAQT2 Strong Biomarker [798]
CHIC2 OTNE3T6Z Strong Altered Expression [799]
CHMP5 OTQWZL6R Strong Altered Expression [800]
CHP1 OTHTXN1A Strong Biomarker [801]
CIB1 OT4BVCRU Strong Altered Expression [802]
CKAP2 OTCLTC0J Strong Altered Expression [803]
CKB OTUCKOTT Strong Altered Expression [804]
CLCA2 OTF191LZ Strong Biomarker [805]
CLDN5 OTUX60YO Strong Altered Expression [705]
CLEC11A OT9KBH7C Strong Genetic Variation [806]
CLEC4D OTT7X1UC Strong Genetic Variation [807]
CMTM5 OTMS7NDP Strong Biomarker [808]
CNDP2 OTJR9436 Strong Altered Expression [68]
CNTNAP1 OT5Y03EU Strong Biomarker [809]
COIL OTP4I4DL Strong Biomarker [810]
COL11A2 OT3BQUBH Strong Altered Expression [487]
CREBRF OT2GK1HI Strong Genetic Variation [811]
CRKL OTOYSD1R Strong Biomarker [812]
CSHL1 OTQKU2F5 Strong Altered Expression [813]
CTBP2 OTGZGT87 Strong Altered Expression [46]
CTNNA1 OTFC725Z Strong Posttranslational Modification [814]
CTNND1 OTUMPSHR Strong Biomarker [286]
CUX1 OTU1LCNJ Strong Altered Expression [815]
CYBA OT16N9ZO Strong Altered Expression [816]
CYTB OTAHB98A Strong Genetic Variation [817]
DACH1 OTMKNAGG Strong Biomarker [818]
DAXX OTX6O7PL Strong Altered Expression [819]
DCDC2 OTSUFH1H Strong Biomarker [820]
DCLRE1C OTW3KB1I Strong Biomarker [821]
DDX41 OT6KEIHP Strong Genetic Variation [822]
DDX43 OTK1RYSK Strong Altered Expression [823]
DESI1 OTFNIW98 Strong Genetic Variation [824]
DHX32 OTDYB66V Strong Altered Expression [825]
DLAT OT9LBJVN Strong Genetic Variation [826]
DLD OT378CU9 Strong Biomarker [827]
DLX3 OTARP5SQ Strong Altered Expression [828]
DLX4 OTLWVCN4 Strong Biomarker [829]
DMBT1 OTVNU9D9 Strong Genetic Variation [830]
DNA2 OT4DJFFU Strong Altered Expression [541]
DNAJC2 OT3JDA0R Strong Biomarker [831]
DNER OT2GH2E5 Strong Biomarker [832]
DOCK2 OTZTS3PA Strong Biomarker [833]
DOK1 OTGVRLW6 Strong Altered Expression [834]
DOK2 OTIJ38UF Strong Altered Expression [835]
DROSHA OTCE68KZ Strong Altered Expression [836]
DUSP2 OTH54FMR Strong Genetic Variation [837]
EAF1 OTN27MJW Strong Biomarker [838]
ECD OT3L3PCU Strong Altered Expression [839]
EFNB1 OT7JJW8P Strong Biomarker [840]
EGR3 OTGPJIRA Strong Biomarker [841]
EIF3A OTFABY9G Strong Biomarker [842]
EIF3D OTDOMP80 Strong Biomarker [843]
EIF4A1 OTMTBX6N Strong Biomarker [844]
EIF4A2 OT08H03R Strong Biomarker [844]
EIF6 OTEXMUED Strong Genetic Variation [628]
EMD OTR8ZANE Strong Biomarker [845]
ENOSF1 OT65D3ZK Strong Biomarker [846]
EPC2 OTTG0W9R Strong Biomarker [847]
ESAM OTF518AI Strong Biomarker [848]
ESPL1 OTMGEVOK Strong Altered Expression [849]
ETV7 OTIAADPA Strong Altered Expression [850]
EVI5 OTOPAP55 Strong Altered Expression [851]
EVPL OTZIAFEK Strong Biomarker [852]
EWSR1 OT7SRHV3 Strong Biomarker [853]
EXT1 OTRPALJK Strong Posttranslational Modification [854]
FANCC OTTIDM3P Strong Biomarker [855]
FANCD2 OTVEB5LF Strong Biomarker [243]
FANCE OTKRPBW1 Strong Biomarker [243]
FANCG OT7MC8TZ Strong Biomarker [243]
FANCL OTJC7QPQ Strong Genetic Variation [856]
FBXO9 OTW5P5JF Strong Biomarker [857]
FCER1A OTIRUOHF Strong Biomarker [858]
FCGR2C OTNLMNYB Strong Biomarker [311]
FEZ1 OTWCXPRE Strong Biomarker [859]
FH OTEQWU6Q Strong Biomarker [860]
FHL2 OT0OAYWT Strong Biomarker [861]
FIP1L1 OTF91GTL Strong Biomarker [862]
FLI1 OT0EV3LX Strong Altered Expression [863]
FLII OT7G9JG6 Strong Altered Expression [863]
FLNC OT3F8J6Y Strong Biomarker [376]
FRAT2 OT481GQ4 Strong Altered Expression [864]
FRYL OTBN3XHN Strong Genetic Variation [865]
FUBP1 OT77SC9N Strong Biomarker [866]
FZD9 OTTZ9MKK Strong Genetic Variation [867]
GAB2 OTBFN705 Strong Genetic Variation [868]
GADD45A OTDRV63V Strong Biomarker [869]
GATA2 OTBP2QQ2 Strong Altered Expression [870]
GFI1 OT9HB9H8 Strong Biomarker [871]
GFI1B OTRDW8YO Strong Genetic Variation [872]
GIPC1 OTXLVCPJ Strong Altered Expression [873]
GLIS2 OTOUUV1X Strong Biomarker [874]
GMPR2 OTKZSZPE Strong Altered Expression [875]
GNL3 OTILGYO4 Strong Biomarker [876]
GNLY OTZJKA8C Strong Altered Expression [877]
GPHN OTAKK1SV Strong Biomarker [878]
GPR180 OT2P0XNK Strong Biomarker [879]
GPRC5A OTPOCWR7 Strong Posttranslational Modification [880]
H2AX OT18UX57 Strong Posttranslational Modification [881]
H2AZ1 OT3KJJNQ Strong Biomarker [410]
H4C1 OTB71W46 Strong Altered Expression [882]
HAVCR2 OTOL603T Strong Altered Expression [373]
HBA1 OTW2BQF4 Strong Altered Expression [326]
HBG1 OTVL4NSU Strong Altered Expression [883]
HBG2 OT4J48JJ Strong Altered Expression [883]
HCFC1 OT0UCK62 Strong Altered Expression [884]
HEMGN OTZPYUOY Strong Altered Expression [885]
HERC5 OTZ5PR39 Strong Biomarker [886]
HERPUD1 OT9EROL6 Strong Genetic Variation [464]
HEY1 OTJQL0I3 Strong Biomarker [741]
HFE OTDD93KB Strong Genetic Variation [887]
HIP1 OT7AKCFQ Strong Altered Expression [888]
HLF OTTRK9XN Strong Biomarker [889]
HOXA1 OTMSOJ7D Strong Biomarker [890]
HOXA3 OTIX5XFB Strong Genetic Variation [335]
HOXA6 OTHJP8M2 Strong Genetic Variation [335]
HOXB1 OTGC0EKI Strong Altered Expression [891]
HOXB2 OTTD6HMV Strong Altered Expression [891]
HOXB4 OTH1HRW5 Strong Biomarker [892]
HOXB5 OTU74TB8 Strong Altered Expression [891]
HOXB6 OT3TFQ0U Strong Altered Expression [891]
HOXB8 OTKHOD17 Strong Altered Expression [891]
HOXB9 OTMVHQOU Strong Altered Expression [891]
HOXC10 OT5WF17M Strong Biomarker [893]
HOXC4 OT52VJ6V Strong Altered Expression [894]
HOXC5 OTPQTLKZ Strong Altered Expression [894]
HOXC6 OTBCRAZV Strong Biomarker [894]
HOXD3 OTBUZ35T Strong Posttranslational Modification [591]
HRK OTR4GWJ0 Strong Altered Expression [895]
HSPA4L OT181WZB Strong Altered Expression [896]
HTN1 OTH3W1RR Strong Biomarker [330]
HTN3 OTEUXA81 Strong Biomarker [897]
ID4 OTPMJ39I Strong Biomarker [898]
IER3 OTZJI5FZ Strong Altered Expression [899]
IFI27 OTI2XGIT Strong Genetic Variation [900]
IGF2BP1 OT9G360P Strong Altered Expression [901]
IGF2BP2 OT4ZSEEE Strong Biomarker [902]
IGF2BP3 OTB97VIK Strong Biomarker [902]
IGFBP4 OT2HZRBD Strong Biomarker [903]
IKBKG OTNWJWSD Strong Genetic Variation [904]
IL2RG OTRZ3OMY Strong Altered Expression [905]
INTS3 OT7NX4CD Strong Biomarker [407]
INVS OT8KPESR Strong Biomarker [906]
IRF2 OTAZRUW3 Strong Biomarker [907]
IRF4 OT1DHQ1P Strong Altered Expression [908]
JARID2 OT14UM8H Strong Biomarker [909]
KAT5 OTL7257A Strong Genetic Variation [910]
KAT7 OTUN98IC Strong Biomarker [911]
KAT8 OT5LPQTR Strong Biomarker [912]
KCNIP3 OTCQPEM4 Strong Altered Expression [895]
KIR2DS4 OT00N6UJ Strong Biomarker [370]
KIR2DS5 OTXLEN11 Strong Biomarker [913]
KLF1 OT1FK08U Strong Altered Expression [914]
KLF10 OT4F4UGS Strong Biomarker [915]
KLF2 OTIP1UFX Strong Biomarker [291]
KRT7 OTLT3JFN Strong Biomarker [543]
KYAT3 OTO4U2QK Strong Biomarker [916]
L3MBTL1 OT8M52QY Strong Genetic Variation [917]
LAT OTZC1XZ1 Strong Genetic Variation [918]
LBR OT1HG3HG Strong Genetic Variation [919]
LDB1 OT20EAPR Strong Biomarker [920]
LEF1 OTWS5I5H Strong Biomarker [642]
LIMS1 OT729S0T Strong Biomarker [921]
LLGL1 OTAIQSXZ Strong Biomarker [922]
LMLN OTQF0JPY Strong Biomarker [906]
LMO1 OTB59SKB Strong Biomarker [923]
LPXN OTUNV3CK Strong Biomarker [924]
LRRC3B OT9VDGPR Strong Biomarker [925]
LRSAM1 OTOKWR6C Strong Genetic Variation [926]
LXN OTZQ2M6Y Strong Posttranslational Modification [927]
MAGED4B OTO37U7W Strong Altered Expression [386]
MAGEF1 OTUU40U3 Strong Altered Expression [928]
MAL OTBM30SW Strong Biomarker [929]
MAPRE2 OTAE3MX4 Strong Altered Expression [930]
MARCKSL1 OT13J2FM Strong Biomarker [931]
MATK OTVOJJLJ Strong Biomarker [375]
MBD3 OTRL76H5 Strong Biomarker [599]
MCM3 OTOOHQPM Strong Altered Expression [932]
ME2 OTO4LL76 Strong Biomarker [933]
MED15 OT0D0JVD Strong Posttranslational Modification [880]
MEF2C OTZGF1Y5 Strong Biomarker [681]
MEF2D OT7CEIG0 Strong Genetic Variation [934]
MEIS2 OTG4ADLM Strong Biomarker [935]
METTL14 OT6TPQMH Strong Biomarker [658]
MIP OTEBLU3E Strong Biomarker [936]
MLC1 OTCNZLSP Strong Posttranslational Modification [937]
MLF1 OTC5BKHU Strong Biomarker [938]
MLLT3 OTXH4DDG Strong Genetic Variation [939]
MLXIPL OTR9MLLW Strong Biomarker [940]
MNAT1 OTXLOYCB Strong Biomarker [941]
MNX1 OTXP9FH1 Strong Genetic Variation [942]
MOV10 OT0KAY9G Strong Biomarker [943]
MRPL28 OT4LUTZU Strong Genetic Variation [944]
MRPS30 OTDXIAGG Strong Genetic Variation [439]
MRTFA OTCVXASM Strong Biomarker [681]
MS4A3 OT0CEJOO Strong Biomarker [945]
MSX1 OT5U41ZP Strong Biomarker [946]
MTCP1 OT4O23TK Strong Genetic Variation [947]
MTPAP OT6HQ02S Strong Genetic Variation [439]
MVP OTJGHJRB Strong Biomarker [948]
MYBL2 OTZ3JX8Q Strong Biomarker [949]
MYOD1 OTV2S79X Strong Biomarker [681]
NAIP OTLA925F Strong Altered Expression [950]
NANOG OTUEY1FM Strong Genetic Variation [951]
NBN OT73B5MD Strong Biomarker [952]
NCKIPSD OT24UORN Strong Biomarker [740]
NCOA2 OTMQFPBB Strong Biomarker [953]
NCOR1 OT04XNOU Strong Genetic Variation [954]
NCOR2 OTY917X0 Strong Genetic Variation [955]
NCR3 OT20M764 Strong Biomarker [956]
NDC80 OTS7D306 Strong Genetic Variation [957]
NFAT5 OTKIE59S Strong Biomarker [958]
NFATC2 OTK5T6HZ Strong Biomarker [959]
NFATC3 OTYOORME Strong Biomarker [958]
NFE2 OTLM94BI Strong Genetic Variation [960]
NKAIN2 OTI4H30Z Strong Biomarker [961]
NME2 OTCYGLHV Strong Altered Expression [962]
NOG OTGRHHPG Strong Biomarker [963]
NOX1 OTZPJQCC Strong Biomarker [964]
NOX5 OTHTH59G Strong Biomarker [965]
NR2E1 OTW47GKM Strong Biomarker [269]
NRARP OTMYHUV2 Strong Biomarker [966]
NRSN1 OT1KKXC8 Strong Biomarker [801]
NSD2 OTQ6SW4R Strong Altered Expression [967]
NUMA1 OTTKAVG4 Strong Biomarker [968]
NXT1 OT0VO6AY Strong Genetic Variation [944]
NYX OTAGXLYP Strong Altered Expression [969]
OLIG2 OTMCN6D3 Strong Altered Expression [970]
OPN1LW OTFNUZ7O Strong Genetic Variation [971]
P2RX5 OTLBR20R Strong Altered Expression [411]
PACC1 OTKBS8CC Strong Biomarker [972]
PACRG OT1NYNNW Strong Genetic Variation [973]
PACSIN2 OTC2R00C Strong Genetic Variation [974]
PAFAH1B1 OT9T2TCJ Strong Biomarker [975]
PAG1 OTFOJUIQ Strong Genetic Variation [971]
PAK3 OT80M3BV Strong Biomarker [316]
PAPOLA OTPHD65D Strong Genetic Variation [439]
PARP4 OTXBK59G Strong Altered Expression [976]
PAX3 OTN5PJZV Strong Biomarker [741]
PBX3 OT8WMVM4 Strong Genetic Variation [977]
PCBP4 OTDLL4NB Strong Genetic Variation [971]
PCDH10 OT2GIT0E Strong Posttranslational Modification [978]
PDAP1 OTJSWMOD Strong Genetic Variation [439]
PDC OT1UUVYY Strong Biomarker [979]
PDCD5 OT6T2DDL Strong Biomarker [980]
PDIK1L OTISF4KG Strong Altered Expression [433]
PDLIM5 OTLQVV22 Strong Biomarker [981]
PGP OT6QQ7OR Strong Biomarker [982]
PHB2 OTCAX3AW Strong Altered Expression [983]
PHC1 OT1JMX8U Strong Altered Expression [984]
PHF6 OT8DXI40 Strong Biomarker [985]
PI4K2B OT0D51QP Strong Biomarker [986]
PIAS1 OTZVAHZI Strong Biomarker [987]
PIAS4 OTB7SVMZ Strong Biomarker [810]
PIP4K2A OTO9JO9U Strong Biomarker [988]
PKD2 OTIXBU8H Strong Biomarker [989]
PLB1 OTZ6TTYV Strong Biomarker [401]
PLEK OTB73XXA Strong Genetic Variation [990]
PLEKHB1 OTC7TNAX Strong Biomarker [449]
PMAIP1 OTXEE550 Strong Biomarker [991]
PMEPA1 OTY8Z9UF Strong Altered Expression [992]
POGLUT1 OTDX7GZD Strong Altered Expression [993]
POLD1 OTWO4UCJ Strong Altered Expression [249]
POLD4 OTG578YH Strong Biomarker [994]
POLE4 OTCMWUT6 Strong Biomarker [994]
POU2F1 OTK7ELJ0 Strong Biomarker [456]
POU3F1 OTYARA94 Strong Biomarker [457]
POU4F1 OTMHYGWQ Strong Biomarker [995]
PPBP OT1FHGQS Strong Genetic Variation [996]
PPP1R13L OTNCPLWE Strong Biomarker [997]
PPP2R5C OTF7CGO2 Strong Biomarker [998]
PRDM1 OTQLSVBS Strong Biomarker [999]
PRDM14 OTWZKY4L Strong Biomarker [784]
PRDM16 OT0BGA27 Strong Biomarker [1000]
PRDM2 OT8L7CGX Strong Genetic Variation [1001]
PRRX1 OTTZK5G8 Strong Biomarker [1002]
PSMA7 OTPHI6ST Strong Biomarker [1003]
PTPRA OTZA82J1 Strong Biomarker [948]
PTPRO OTFLKWOY Strong Genetic Variation [1004]
PTPRU OTHDO0QG Strong Biomarker [522]
PVR OT3N91T7 Strong Biomarker [1005]
QRSL1 OTJDU2UG Strong Biomarker [1006]
RAB40B OTCA9ZF5 Strong Altered Expression [1007]
RAB8A OTPB54Y3 Strong Biomarker [1008]
RAC2 OTAOHFNH Strong Altered Expression [1009]
RAD52 OT0OTDHI Strong Altered Expression [1010]
RAG2 OTG9UYTW Strong Biomarker [1011]
RALGAPB OTY8CGA3 Strong Genetic Variation [730]
RANGAP1 OTZGD3LJ Strong Altered Expression [1012]
RAP1GAP OTC31ONQ Strong Biomarker [1013]
RARRES1 OTETUPP5 Strong Posttranslational Modification [880]
RASGRF1 OTNWJ7EN Strong Altered Expression [1014]
RASSF10 OTGB7EBG Strong Biomarker [1015]
RASSF6 OT25GVWY Strong Altered Expression [1015]
RBM15 OT8ZPGWF Strong Biomarker [1016]
RBM6 OTI99KAZ Strong Genetic Variation [1017]
RBMXL1 OTMGCWWB Strong Biomarker [916]
RCBTB2 OTECBF4R Strong Altered Expression [1018]
RECQL4 OT59LSW7 Strong Biomarker [846]
REPS1 OTX4ERRK Strong Biomarker [1019]
RFC1 OT3L5PK3 Strong Biomarker [1020]
RGCC OTYJMLWM Strong Altered Expression [1021]
RHOXF2 OTKQWLKZ Strong Biomarker [1022]
RIN1 OTPBROUD Strong Altered Expression [1023]
RNF20 OT9NK6ZT Strong Biomarker [1024]
ROPN1L OTRWZJ68 Strong Biomarker [230]
RPN1 OTEG4KU9 Strong Genetic Variation [1025]
RPS19 OTBKGP48 Strong Biomarker [160]
RPS6 OTT4D1LN Strong Biomarker [1026]
RTEL1 OTI3PJCT Strong Genetic Variation [1027]
RUVBL2 OTGWJ4T4 Strong Biomarker [1028]
S100A11 OTI57KDN Strong Altered Expression [317]
SACM1L OT6ORKTD Strong Biomarker [1029]
SALL4 OTC08PR5 Strong Altered Expression [1030]
SAMHD1 OTBCIBC7 Strong Biomarker [1031]
SCD5 OTSSUQ3Z Strong Biomarker [1032]
SCYL1 OTQ0IN7P Strong Altered Expression [404]
SEMG1 OT6Z4BPQ Strong Biomarker [798]
SERP2 OT5GA6JZ Strong Genetic Variation [1033]
SERPINA4 OTBK0GG7 Strong Biomarker [1034]
SETD1A OTVVWRIC Strong Biomarker [1035]
SETX OTG3JNOQ Strong Biomarker [1036]
SFRP5 OTLCVVSH Strong Biomarker [1037]
SGK3 OTQ6QO99 Strong Biomarker [689]
SH2D1A OTLU49I5 Strong Genetic Variation [1038]
SH3BP2 OT90JNBS Strong Biomarker [858]
SH3BP4 OTVIRKW7 Strong Biomarker [1039]
SHB OTF2HSC0 Strong Biomarker [852]
SIAH2 OTKED2XN Strong Altered Expression [1040]
SIGLEC7 OTNDLURR Strong Biomarker [1041]
SIGLEC9 OTZC7SIM Strong Biomarker [1041]
SLC12A9 OTR7VRAK Strong Altered Expression [1042]
SLC35G1 OTKZUA8O Strong Genetic Variation [824]
SMAD5 OTQNSVCQ Strong Biomarker [1043]
SMARCA5 OT5GR4Z2 Strong Biomarker [1044]
SMARCD2 OTQTBWHW Strong Biomarker [1045]
SMC4 OTEJE6AG Strong Biomarker [1046]
SMCHD1 OTBV52DR Strong Altered Expression [1047]
SMPD3 OTHQBETH Strong Genetic Variation [1048]
SMPX OTLSHGBF Strong Altered Expression [813]
SMYD5 OTE5VET6 Strong Altered Expression [1049]
SNF8 OTRQA2AI Strong Biomarker [1050]
SOAT1 OTB4Y5RJ Strong Biomarker [1051]
SOCS2 OTBPNKJQ Strong Altered Expression [1052]
SOCS5 OTN1ABYR Strong Altered Expression [1053]
SON OT9VWV18 Strong Altered Expression [1054]
SOX11 OT4LG7LA Strong Altered Expression [1055]
SOX12 OT93P8C9 Strong Altered Expression [1056]
SOX6 OTT0W0LE Strong Genetic Variation [1057]
SOX7 OTOZOFAG Strong Altered Expression [1058]
SPAG9 OT45AHMB Strong Genetic Variation [1059]
SPANXB1 OTLMGC9T Strong Genetic Variation [1060]
SPI1 OTVCA1D0 Strong Altered Expression [1061]
SPIB OTO4YKYI Strong Altered Expression [1062]
SPINK6 OTYKZANJ Strong Biomarker [1034]
SRI OT4R3EAC Strong Altered Expression [1063]
SSX2 OT2Z6RLL Strong Genetic Variation [1064]
STIL OT9799VN Strong Biomarker [641]
STIM2 OTYNXAW0 Strong Biomarker [1065]
SUB1 OTK71JYU Strong Genetic Variation [944]
SUMO1 OTJFD4P5 Strong Biomarker [1066]
SUV39H2 OTU0F4LL Strong Altered Expression [1067]
SWT1 OTY4AFM1 Strong Biomarker [1068]
TAC1 OTM842YW Strong Biomarker [1069]
TALDO1 OTDKV2S2 Strong Genetic Variation [926]
TBPL1 OT4I143E Strong Biomarker [474]
TCF7 OT1ID822 Strong Altered Expression [1070]
TCN2 OT41D0L3 Strong Altered Expression [1071]
TEF OTY3LAD9 Strong Altered Expression [1072]
TELO2 OT2YQ9L8 Strong Altered Expression [850]
TES OTL8PP6V Strong Biomarker [1073]
TESC OTI8C76M Strong Altered Expression [1074]
TFCP2 OTA246TE Strong Altered Expression [1075]
TFPT OTM70AK1 Strong Altered Expression [1076]
TFR2 OTMYCCEO Strong Altered Expression [1077]
TGFBI OTR443C5 Strong Altered Expression [1078]
THOC5 OTHY50SK Strong Biomarker [1079]
THUMPD1 OTKU8KWH Strong Biomarker [1080]
TIGAR OTR7NMRJ Strong Biomarker [1081]
TLX3 OTBUHHK3 Strong Altered Expression [985]
TMED2 OTBLO7RW Strong Biomarker [801]
TMEM132D OTV6I4Z0 Strong Genetic Variation [1082]
TNFRSF10C OTVHOL9B Strong Posttranslational Modification [1083]
TNFRSF10D OTOSRDJT Strong Genetic Variation [1083]
TNFSF8 OTDYGDJ3 Strong Biomarker [481]
TNIP2 OTDQWTUB Strong Altered Expression [1084]
TPM3 OT5RU5G6 Strong Biomarker [1085]
TPPP OTCFMSUF Strong Biomarker [801]
TRABD OTCFGFJH Strong Genetic Variation [1086]
TRAF1 OTTLM5RU Strong Biomarker [1087]
TRAF3 OT5TQBGV Strong Genetic Variation [1088]
TRIM32 OTJOV0PG Strong Biomarker [1089]
TRIM35 OTT9V87M Strong Genetic Variation [1090]
TRIM5 OTMZH7EJ Strong Biomarker [1091]
TRIM62 OT15YO6N Strong Altered Expression [1092]
TRPV5 OTWF4L0U Strong Biomarker [493]
TSC22D3 OT03UM03 Strong Biomarker [1093]
TSGA10 OTIF1O1T Strong Altered Expression [1094]
TSPAN3 OT7WS6ZI Strong Biomarker [1095]
ARL6IP5 OTYZ6BEQ Definitive Genetic Variation [1096]
CSNK2A3 OTZP4KZK Definitive Altered Expression [1097]
DTX2 OT7QLDU4 Definitive Genetic Variation [1098]
FCHSD2 OTKXLIJ6 Definitive Altered Expression [1099]
FLVCR1 OT9XCFOC Definitive Genetic Variation [1100]
FMOD OT9EJ5H8 Definitive Biomarker [1101]
GPX3 OT6PK94R Definitive Posttranslational Modification [1102]
GSTK1 OTDNGWAF Definitive Genetic Variation [525]
KDM3B OTZU5J5S Definitive Biomarker [1103]
LARP6 OTUQ9QS9 Definitive Altered Expression [1104]
MACROD1 OTWFEVRW Definitive Biomarker [1105]
METTL3 OTSXP1M3 Definitive Biomarker [1106]
POLM OT0SRIP4 Definitive Altered Expression [1107]
TAF15 OTNE038N Definitive Biomarker [1108]
TEAD1 OTK6971C Definitive Biomarker [1109]
TFPI2 OTZCRWOR Definitive Biomarker [1109]
TLE1 OT50MRZ1 Definitive Biomarker [1110]
TOX OTE8BL5Z Definitive Biomarker [1111]
------------------------------------------------------------------------------------
⏷ Show the Full List of 742 DOT(s)

References

1 Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer. Drugs. 1993 Sep;46(3):446-514.
2 T-Cell Prolymphocytic Leukemia: Diagnosis, Pathogenesis, and Treatment. Int J Mol Sci. 2023 Jul 28;24(15):12106.
3 Arsenic trioxide FDA Label
4 Azacitidine FDA Label
5 Bortezomib FDA Label
6 Busulfan FDA Label
7 Clofarabine FDA Label
8 Cyproheptadine FDA Label
9 Dasatinib FDA Label
10 Daunorubicin FDA Label
11 Doxorubicin FDA Label
12 Everolimus FDA Label
13 Gemcitabine FDA Label
14 Idarubicin FDA Label
15 Imatinib FDA Label
16 Lenalidomide FDA Label
17 Melphalan FDA Label
18 Methotrexate FDA Label
19 Methylprednisolone FDA Label
20 Mitoxantrone FDA Label
21 New conjugates of mycophenolic acid and their antiproliferative activity. J Asian Nat Prod Res. 2016 Nov;18(11):1057-62.
22 Omacetaxine mepesuccinate FDA Label
23 Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001. J Clin Oncol. 2021 Nov 1;39(31):3496-3505.
24 Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med. 2010 Dec 23;363(26):2511-21.
25 Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study. Lancet Haematol. 2020 Mar;7(3):e196-e208.
26 Pentostatin FDA Label
27 Prednisolone FDA Label
28 Propofol FDA Label
29 Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Cancer. 2006 Apr 1;106(7):1569-80.
30 Tacrolimus FDA Label
31 Thalidomide FDA Label
32 Thiotepa FDA Label
33 Vincristine FDA Label
34 Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways. Reprod Biol Endocrinol. 2020 Oct 12;18(1):100.
35 Choline FDA Label
36 A causal mechanism for childhood acute lymphoblastic leukaemia.Nat Rev Cancer. 2018 Aug;18(8):471-484. doi: 10.1038/s41568-018-0015-6.
37 Development and pharmaceutical evaluation of the anticancer Anthrafuran/Cavitron complex, a prototypic parenteral drug formulation.Eur J Pharm Sci. 2017 Nov 15;109:631-637. doi: 10.1016/j.ejps.2017.09.025. Epub 2017 Sep 18.
38 Expression and modulation of annexin VIII in human leukemia-lymphoma cell lines.Leuk Res. 1993 Nov;17(11):949-57. doi: 10.1016/0145-2126(93)90042-j.
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43 Identification of the BRAF V600E mutation in Japanese patients with hairy cell leukemia and related diseases using a quenching probe method.Int J Hematol. 2018 Oct;108(4):416-422. doi: 10.1007/s12185-018-2506-3. Epub 2018 Jul 24.
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47 Multiple myeloma secondary to acute lymphoblastic leukemia: A case report.Medicine (Baltimore). 2019 Jan;98(1):e14018. doi: 10.1097/MD.0000000000014018.
48 CAR T cell therapy: A new era for cancer treatment (Review).Oncol Rep. 2019 Dec;42(6):2183-2195. doi: 10.3892/or.2019.7335. Epub 2019 Sep 24.
49 A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia.Blood. 2017 Nov 30;130(22):2410-2419. doi: 10.1182/blood-2017-04-777052. Epub 2017 Oct 17.
50 Generation of Suicide Gene-Modified Chimeric Antigen Receptor-Redirected T-Cells for Cancer Immunotherapy.Methods Mol Biol. 2019;1895:57-73. doi: 10.1007/978-1-4939-8922-5_5.
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52 ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52).Clin Microbiol Infect. 2018 Jun;24 Suppl 2:S71-S82. doi: 10.1016/j.cmi.2018.02.003. Epub 2018 Feb 12.
53 IL-15/IL-15R/CD80-expressing AML cell vaccines eradicate minimal residual disease in leukemic mice.Blood Adv. 2018 Nov 27;2(22):3177-3192. doi: 10.1182/bloodadvances.2018019026.
54 Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1.Int J Mol Med. 2016 May;37(5):1405-11. doi: 10.3892/ijmm.2016.2539. Epub 2016 Mar 24.
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56 CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex.Leukemia. 2019 Jul;33(7):1608-1619. doi: 10.1038/s41375-019-0382-3. Epub 2019 Jan 24.
57 Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia.J Hematol Oncol. 2016 Feb 18;9:12. doi: 10.1186/s13045-016-0241-x.
58 Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis.Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12790-5. doi: 10.1073/pnas.0701437104. Epub 2007 Jul 23.
59 High-expressing cystic fibrosis transmembrane conductance regulator interacts with histone deacetylase 2 to promote the development of Ph+ leukemia through the HDAC2-mediated PTEN pathway.Leuk Res. 2017 Jun;57:9-19. doi: 10.1016/j.leukres.2017.02.004. Epub 2017 Feb 16.
60 Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells.Mol Cancer. 2014 Jun 10;13:147. doi: 10.1186/1476-4598-13-147.
61 The CLEC12A receptor marks human basophils: Potential implications for minimal residual disease detection in acute myeloid leukemia.Cytometry B Clin Cytom. 2018 May;94(3):520-526. doi: 10.1002/cyto.b.21540. Epub 2017 Aug 11.
62 L233P mutation in the bovine leukemia virus Tax protein depresses endothelial cell recruitment and tumorigenesis in athymic nude mice.Arch Virol. 2019 May;164(5):1343-1351. doi: 10.1007/s00705-019-04191-3. Epub 2019 Mar 8.
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64 CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia.Int J Mol Sci. 2019 Jun 5;20(11):2764. doi: 10.3390/ijms20112764.
65 Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model.Cancer Lett. 2020 Jan 28;469:151-161. doi: 10.1016/j.canlet.2019.10.032. Epub 2019 Oct 24.
66 The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.Cell Rep. 2019 Apr 2;27(1):238-254.e6. doi: 10.1016/j.celrep.2019.03.009.
67 Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia.PLoS One. 2015 May 18;10(5):e0127308. doi: 10.1371/journal.pone.0127308. eCollection 2015.
68 Cytotoxic activity of gemcitabine and correlation with expression profile of drug-related genes in human lymphoid cells.Pharmacol Res. 2007 Apr;55(4):343-9. doi: 10.1016/j.phrs.2007.01.003. Epub 2007 Jan 16.
69 Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement.BMC Cancer. 2018 Apr 12;18(1):409. doi: 10.1186/s12885-018-4327-4.
70 Alternative splicing generates a diacylglycerol kinase transcript that acts as a dominant-negative modulator of superoxide production in localized aggressive periodontitis.J Periodontol. 2014 Jul;85(7):934-43. doi: 10.1902/jop.2013.130468. Epub 2013 Oct 30.
71 Overexpression of DICER1 induced by the upregulation of GATA1 contributes to the proliferation and apoptosis of leukemia cells.Int J Oncol. 2013 Apr;42(4):1317-24. doi: 10.3892/ijo.2013.1831. Epub 2013 Feb 19.
72 Cross-talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway.Carcinogenesis. 2013 Mar;34(3):667-77. doi: 10.1093/carcin/bgs386. Epub 2012 Dec 13.
73 Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-.Elife. 2017 Apr 20;6:e21697. doi: 10.7554/eLife.21697.
74 Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120Ubiquitination.Mol Cell. 2019 Jun 6;74(5):1010-1019.e6. doi: 10.1016/j.molcel.2019.03.029. Epub 2019 Apr 10.
75 c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals.Blood. 2017 Dec 21;130(25):2739-2749. doi: 10.1182/blood-2017-02-769463. Epub 2017 Oct 27.
76 Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1.Sci Rep. 2019 Aug 14;9(1):11861. doi: 10.1038/s41598-019-47891-1.
77 Nuclear, not cytoplasmic, PKR maneuvers in AML.Blood. 2015 Sep 24;126(13):1523-4. doi: 10.1182/blood-2015-08-661421.
78 Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism.Mol Cancer Ther. 2014 Mar;13(3):662-74. doi: 10.1158/1535-7163.MCT-13-0714. Epub 2013 Dec 20.
79 Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.Nat Commun. 2019 Nov 7;10(1):5051. doi: 10.1038/s41467-019-12960-6.
80 Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.Cancer Cell. 2018 Feb 12;33(2):274-291.e8. doi: 10.1016/j.ccell.2018.01.006.
81 Blood monocyte profiles in COPD patients with PiMM and PiZZ 1-antitrypsin.Respir Med. 2019 Mar;148:60-62. doi: 10.1016/j.rmed.2019.02.001. Epub 2019 Feb 6.
82 DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4).BMC Cancer. 2012 Jan 17;12:19. doi: 10.1186/1471-2407-12-19.
83 Effects of metformin on FOXM1 expression and on the biological behavior of acute leukemia cell lines.Mol Med Rep. 2014 Dec;10(6):3193-8. doi: 10.3892/mmr.2014.2629. Epub 2014 Oct 13.
84 Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han.Front Immunol. 2019 Jul 16;10:1646. doi: 10.3389/fimmu.2019.01646. eCollection 2019.
85 Association of glutathione S-transferase 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.Arch Toxicol. 2012 Jun;86(6):857-68. doi: 10.1007/s00204-012-0802-x.
86 Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?.Curr Opin Allergy Clin Immunol. 2007 Dec;7(6):481-94. doi: 10.1097/ACI.0b013e3282f1d690.
87 HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.Leukemia. 2018 Jan;32(1):49-60. doi: 10.1038/leu.2017.174. Epub 2017 Jun 5.
88 Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320.Theranostics. 2019 Jul 28;9(19):5642-5656. doi: 10.7150/thno.34813. eCollection 2019.
89 Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth.Exp Cell Res. 2019 Sep 15;382(2):111485. doi: 10.1016/j.yexcr.2019.06.030. Epub 2019 Jun 26.
90 Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening.Bioorg Med Chem. 2019 Aug 1;27(15):3229-3236. doi: 10.1016/j.bmc.2019.05.040. Epub 2019 May 28.
91 IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2R therapies.Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21120-21130. doi: 10.1073/pnas.1901382116. Epub 2019 Sep 30.
92 Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS-related tyrosine kinase 3 receptor.Br J Haematol. 2009 Feb;144(3):376-87. doi: 10.1111/j.1365-2141.2008.07491.x. Epub 2008 Nov 13.
93 Cytogenetic and Cytogenomic Microarray Characterization of Chromothripsis in Chromosome 8 Affecting MOZ/NCOA2 (TIF2), FGFR1, RUNX1T1, and RUNX1 in a Pediatric Acute Myeloid Leukemia.J Pediatr Hematol Oncol. 2017 May;39(4):e227-e232. doi: 10.1097/MPH.0000000000000770.
94 Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy.Cell Res. 2019 Jun;29(6):446-459. doi: 10.1038/s41422-019-0162-7. Epub 2019 Apr 25.
95 Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies.Onco Targets Ther. 2019 Jan 18;12:635-645. doi: 10.2147/OTT.S189391. eCollection 2019.
96 Gene mutation profile and risk stratification in AML1ETOpositive acute myeloid leukemia based on nextgeneration sequencing.Oncol Rep. 2019 Dec;42(6):2333-2344. doi: 10.3892/or.2019.7375. Epub 2019 Oct 15.
97 Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica sinensis (Oliv.) Diels.Int J Biol Macromol. 2019 Jan;121:161-172. doi: 10.1016/j.ijbiomac.2018.09.213. Epub 2018 Oct 2.
98 The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.Nat Cell Biol. 2015 May;17(5):665-77. doi: 10.1038/ncb3158. Epub 2015 Apr 27.
99 CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets.Leukemia. 2005 May;19(5):835-40. doi: 10.1038/sj.leu.2403704.
100 Involvement of NF-B in mediating the anti-tumour effects of combretastatins in T cells.Invest New Drugs. 2018 Aug;36(4):523-535. doi: 10.1007/s10637-017-0543-z. Epub 2018 Feb 19.
101 LIFR-CT3 induces differentiation of a human acute myelogenous leukemia cell line HL-60 by suppressing miR-155 expression through the JAK/STAT pathway.Leuk Res. 2014 Oct;38(10):1237-44. doi: 10.1016/j.leukres.2014.07.004. Epub 2014 Jul 22.
102 Understanding PIM-1 kinase inhibitor interactions with free energy simulation.Phys Chem Chem Phys. 2019 Apr 3;21(14):7544-7558. doi: 10.1039/c9cp00070d.
103 Oral MEK 1/2 Inhibitor Trametinib in Combination With AKT Inhibitor GSK2141795 in Patients With Acute Myeloid Leukemia With RAS Mutations: A Phase II Study.Clin Lymphoma Myeloma Leuk. 2019 Jul;19(7):431-440.e13. doi: 10.1016/j.clml.2019.03.015. Epub 2019 Mar 26.
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105 Effect of a nutrient mixture on matrix metalloproteinase-9 dimers in various human cancer cell lines.Int J Oncol. 2014 Mar;44(3):986-92. doi: 10.3892/ijo.2013.2235. Epub 2013 Dec 30.
106 Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation.Carcinogenesis. 2019 Apr 29;40(2):216-224. doi: 10.1093/carcin/bgz013.
107 Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations.EMBO Mol Med. 2013 Jan;5(1):38-51. doi: 10.1002/emmm.201201703. Epub 2012 Dec 11.
108 CAR-T "the living drugs", immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy.J Hematol Oncol. 2019 Nov 8;12(1):113. doi: 10.1186/s13045-019-0819-1.
109 The AAA+ATPase RUVBL2 is essential for the oncogenic function of c-MYB in acute myeloid leukemia.Leukemia. 2019 Dec;33(12):2817-2829. doi: 10.1038/s41375-019-0495-8. Epub 2019 May 28.
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111 [Transcription levels of the MYCN gene in blood cell subpopulations of Patients with leukemia].Mol Biol (Mosk). 2008 Mar-Apr;42(2):378-82.
112 MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells.Anticancer Res. 2017 Nov;37(11):6203-6209. doi: 10.21873/anticanres.12070.
113 Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway.Leuk Res. 2018 Jun;69:39-46. doi: 10.1016/j.leukres.2018.04.004. Epub 2018 Apr 5.
114 A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis.Oncotarget. 2014 Jul 30;5(14):5494-509. doi: 10.18632/oncotarget.2131.
115 The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors.Cell Cycle. 2019 Sep;18(18):2307-2322. doi: 10.1080/15384101.2019.1646068. Epub 2019 Jul 26.
116 Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.Oncogene. 2018 Jul;37(28):3839-3851. doi: 10.1038/s41388-018-0234-z. Epub 2018 Apr 12.
117 HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML.Leukemia. 2013 Jun;27(6):1358-68. doi: 10.1038/leu.2012.366. Epub 2012 Dec 18.
118 Semaphorins and Their Receptors in Hematological Malignancies.Front Oncol. 2019 May 9;9:382. doi: 10.3389/fonc.2019.00382. eCollection 2019.
119 Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.PLoS One. 2018 Aug 23;13(8):e0202677. doi: 10.1371/journal.pone.0202677. eCollection 2018.
120 Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair.Eur Cell Mater. 2013 Sep 11;26:80-90; discussion 90. doi: 10.22203/ecm.v026a06.
121 PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.PLoS Genet. 2019 Aug 5;15(8):e1008280. doi: 10.1371/journal.pgen.1008280. eCollection 2019 Aug.
122 SIL-TAL1 rearrangement is related with poor outcome: a study from a Chinese institution.PLoS One. 2013 Sep 9;8(9):e73865. doi: 10.1371/journal.pone.0073865. eCollection 2013.
123 Promyelocytic leukemia protein in mesenchymal stem cells is essential for leukemia progression.Ann Hematol. 2018 Oct;97(10):1749-1755. doi: 10.1007/s00277-018-3463-x. Epub 2018 Aug 1.
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125 Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.Eur J Med Chem. 2019 Feb 15;164:317-333. doi: 10.1016/j.ejmech.2018.12.065. Epub 2018 Dec 26.
126 DNA Aptamers in the Detection of Leukemia Cells by the Thickness Shear Mode Acoustics Method.Chemphyschem. 2019 Feb 18;20(4):545-554. doi: 10.1002/cphc.201801126. Epub 2019 Feb 6.
127 DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy.Cancers (Basel). 2019 Jun 23;11(6):877. doi: 10.3390/cancers11060877.
128 RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia.Hum Pathol. 2018 Oct;80:82-86. doi: 10.1016/j.humpath.2018.02.023. Epub 2018 Mar 10.
129 Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha.Oncotarget. 2017 Mar 21;8(12):20103-20112. doi: 10.18632/oncotarget.15384.
130 The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin.Cell Death Dis. 2018 May 29;9(6):656. doi: 10.1038/s41419-018-0689-4.
131 Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression.Apoptosis. 2015 Aug;20(8):1087-98. doi: 10.1007/s10495-015-1135-z.
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133 p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription.Oncotarget. 2017 Jan 3;8(1):1678-1687. doi: 10.18632/oncotarget.13779.
134 Imatinib restores expression of CD62L in BCR-ABL-positive cells.J Leukoc Biol. 2003 May;73(5):600-3. doi: 10.1189/jlb.1002507.
135 Prognostic value and clinical feature of SF3B1 mutations in myelodysplastic syndromes: A meta-analysis.Crit Rev Oncol Hematol. 2019 Jan;133:74-83. doi: 10.1016/j.critrevonc.2018.07.013. Epub 2018 Aug 3.
136 PI3K p110 inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression.J Clin Invest. 2019 Jan 2;129(1):122-136. doi: 10.1172/JCI99386. Epub 2018 Nov 19.
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140 Expression of TRAIL and its receptor DR5 and their significance in acute leukemia cells.Genet Mol Res. 2015 Dec 28;14(4):18562-8.
141 B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia.Biomed Res Int. 2015;2015:792187. doi: 10.1155/2015/792187. Epub 2015 Aug 3.
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145 Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.JCI Insight. 2019 Oct 3;4(19):e127716. doi: 10.1172/jci.insight.127716.
146 Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.Blood. 2017 Feb 23;129(8):981-990. doi: 10.1182/blood-2016-06-721191. Epub 2017 Jan 9.
147 Role of ZNF224 in cell growth and chemoresistance of chronic lymphocitic leukemia.Hum Mol Genet. 2017 Jan 15;26(2):344-353. doi: 10.1093/hmg/ddw427.
148 ABR, a novel inducer of transcription factor C/EBP, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia.Oncotarget. 2017 Oct 26;8(61):103626-103639. doi: 10.18632/oncotarget.22093. eCollection 2017 Nov 28.
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150 High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer.Dig Dis Sci. 2018 Sep;63(9):2294-2300. doi: 10.1007/s10620-018-5111-7. Epub 2018 May 16.
151 Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms. J Exp Clin Cancer Res. 2019 Jul 15;38(1):308. doi: 10.1186/s13046-019-1295-8.
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552 Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models.Emerg Microbes Infect. 2019;8(1):1108-1121. doi: 10.1080/22221751.2019.1637072.
553 The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis.J Hematol Oncol. 2018 Feb 26;11(1):27. doi: 10.1186/s13045-018-0567-7.
554 Association of ARID5B and IKZF1 Variants with Leukemia from Northern India.Genet Test Mol Biomarkers. 2019 Mar;23(3):176-179. doi: 10.1089/gtmb.2018.0283. Epub 2019 Feb 27.
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557 SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.Oncogene. 2006 Aug 24;25(37):5180-6. doi: 10.1038/sj.onc.1209520. Epub 2006 Apr 24.
558 Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.Exp Hematol. 2019 Jun;74:42-51.e3. doi: 10.1016/j.exphem.2019.04.003. Epub 2019 May 13.
559 CBF-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048.
560 CytCD79a expression in acute leukemia with t(8;21): biphenotypic or myeloid leukemia?.Cancer Genet Cytogenet. 2007 Apr 1;174(1):76-7. doi: 10.1016/j.cancergencyto.2006.11.007.
561 Association of genetic variation in IKZF1, ARID5B, CDKN2A, and CEBPE with the risk of acute lymphoblastic leukemia in Tunisian children and their contribution to racial differences in leukemia incidence.Pediatr Hematol Oncol. 2016 Apr;33(3):157-67. doi: 10.3109/08880018.2016.1161685.
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563 The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells.Gene Expr Patterns. 2004 Jul;4(4):389-95. doi: 10.1016/j.modgep.2004.01.008.
564 Knock-down of CIAPIN1 sensitizes K562 chronic myeloid leukemia cells to Imatinib by regulation of cell cycle and apoptosis-associated members via NF-B and ERK5 signaling pathway.Biochem Pharmacol. 2016 Jan 1;99:132-45. doi: 10.1016/j.bcp.2015.12.002. Epub 2015 Dec 8.
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566 Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia.Pediatr Blood Cancer. 2019 Oct;66(10):e27897. doi: 10.1002/pbc.27897. Epub 2019 Jun 28.
567 IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia.Transl Oncol. 2019 May;12(5):726-732. doi: 10.1016/j.tranon.2019.02.002. Epub 2019 Mar 13.
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569 CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27(kip1) signaling.Haematologica. 2017 Apr;102(4):707-718. doi: 10.3324/haematol.2016.151555. Epub 2017 Jan 25.
570 Germline factor DDX4 functions in blood-derived cancer cell phenotypes.Cancer Sci. 2017 Aug;108(8):1612-1619. doi: 10.1111/cas.13299. Epub 2017 Jul 11.
571 Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia.Pediatr Blood Cancer. 2014 Dec;61(12):2230-5. doi: 10.1002/pbc.25221. Epub 2014 Sep 11.
572 AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.Mol Cell. 2010 Feb 12;37(3):429-37. doi: 10.1016/j.molcel.2010.01.026.
573 Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil.J Comp Pathol. 2019 Jan;166:20-28. doi: 10.1016/j.jcpa.2018.10.171. Epub 2018 Nov 29.
574 Polymorphisms in XPC, XPD and XPG DNA repair genes and leukemia risk in a Tunisian population.Leuk Lymphoma. 2015 Jun;56(6):1856-62. doi: 10.3109/10428194.2014.974045. Epub 2014 Nov 14.
575 Downregulation of ENDOCAN in myeloid leukemia cells inhibits proliferation and promotes apoptosis by suppressing nuclear factorB activity.Mol Med Rep. 2019 Apr;19(4):3247-3254. doi: 10.3892/mmr.2019.9969. Epub 2019 Feb 19.
576 Gene profiling of Graffi murine leukemia virus-induced lymphoid leukemias: identification of leukemia markers and Fmn2 as a potential oncogene.Blood. 2011 Feb 10;117(6):1899-910. doi: 10.1182/blood-2010-10-311001. Epub 2010 Dec 6.
577 Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells.Clin Cancer Res. 2005 Jun 15;11(12):4504-11. doi: 10.1158/1078-0432.CCR-05-0036.
578 FAM168A participates in the development of chronic myeloid leukemia via BCR-ABL1/AKT1/NFB pathway.BMC Cancer. 2019 Jul 10;19(1):679. doi: 10.1186/s12885-019-5898-4.
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580 Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia.Br J Haematol. 2008 Sep;142(5):745-53. doi: 10.1111/j.1365-2141.2008.07242.x. Epub 2008 Jun 3.
581 CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells.PLoS One. 2014 Feb 10;9(2):e85328. doi: 10.1371/journal.pone.0085328. eCollection 2014.
582 MicroRNA in leukemia: Tumor suppressors and oncogenes with prognostic potential.J Cell Physiol. 2019 Jun;234(6):8465-8486. doi: 10.1002/jcp.27776. Epub 2018 Dec 4.
583 GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.Biomed Pharmacother. 2016 Dec;84:1568-1574. doi: 10.1016/j.biopha.2016.10.032. Epub 2016 Nov 6.
584 Molecular pathogenesis of disease progression in MLL-rearranged AML.Leukemia. 2019 Mar;33(3):612-624. doi: 10.1038/s41375-018-0253-3. Epub 2018 Sep 12.
585 The Marine Natural Product Pseudopterosin Blocks Cytokine Release of Triple-Negative Breast Cancer and Monocytic Leukemia Cells by Inhibiting NF-B Signaling.Mar Drugs. 2017 Aug 23;15(9):262. doi: 10.3390/md15090262.
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587 Inactivation of the hypermethylated in cancer 1 tumour suppressor--not just a question of promoter hypermethylation?.Swiss Med Wkly. 2010 Nov 1;140:w13106. doi: 10.4414/smw.2010.13106. eCollection 2010.
588 TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.Blood. 2012 Apr 12;119(15):3440-9. doi: 10.1182/blood-2011-06-357939. Epub 2012 Feb 27.
589 Oncogenic heterogeneous nuclear ribonucleoprotein D-like modulates the growth and imatinib response of human chronic myeloid leukemia CD34(+) cells via pre-B-cell leukemia homeobox 1.Oncogene. 2020 Jan;39(2):443-453. doi: 10.1038/s41388-019-0998-9. Epub 2019 Sep 5.
590 The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.Oncogene. 2018 May;37(19):2532-2544. doi: 10.1038/s41388-018-0131-5. Epub 2018 Feb 20.
591 Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.Clin Cancer Res. 2007 Sep 1;13(17):5048-55. doi: 10.1158/1078-0432.CCR-07-0919.
592 Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.Blood. 2008 Sep 1;112(5):2017-9. doi: 10.1182/blood-2008-01-135186. Epub 2008 Jun 19.
593 The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors.Mini Rev Med Chem. 2016;16(16):1344-1358. doi: 10.2174/1389557516666160609085520.
594 Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.Leukemia. 2019 Jul;33(7):1583-1597. doi: 10.1038/s41375-018-0369-5. Epub 2019 Jan 24.
595 Bone marrow adipocytes support hematopoietic stem cell survival.J Cell Physiol. 2018 Feb;233(2):1500-1511. doi: 10.1002/jcp.26037. Epub 2017 Aug 3.
596 Dioncophyllines C(2), D(2), and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines.J Nat Prod. 2017 Feb 24;80(2):443-458. doi: 10.1021/acs.jnatprod.6b00967. Epub 2017 Jan 25.
597 The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML.Leukemia. 2019 Nov;33(11):2628-2639. doi: 10.1038/s41375-019-0581-y. Epub 2019 Oct 1.
598 Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.J Clin Invest. 2016 Mar 1;126(3):905-20. doi: 10.1172/JCI84014. Epub 2016 Jan 25.
599 MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia.FASEB J. 2019 Apr;33(4):5268-5286. doi: 10.1096/fj.201801035R. Epub 2019 Jan 22.
600 The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer.Front Oncol. 2018 Nov 14;8:502. doi: 10.3389/fonc.2018.00502. eCollection 2018.
601 High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations.Blood. 2012 Mar 8;119(10):e67-75. doi: 10.1182/blood-2011-09-380444. Epub 2012 Jan 10.
602 Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia.J Clin Oncol. 2011 Feb 20;29(6):682-9. doi: 10.1200/JCO.2010.31.1118. Epub 2011 Jan 4.
603 Activation of the Lysosome-Associated Membrane Protein LAMP5 by DOT1L Serves as a Bodyguard for MLL Fusion Oncoproteins to Evade Degradation in Leukemia.Clin Cancer Res. 2019 May 1;25(9):2795-2808. doi: 10.1158/1078-0432.CCR-18-1474. Epub 2019 Jan 16.
604 Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia.Blood Adv. 2019 May 14;3(9):1499-1511. doi: 10.1182/bloodadvances.2018026054.
605 Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.Exp Hematol. 2019 Jan;69:37-42. doi: 10.1016/j.exphem.2018.10.001. Epub 2018 Oct 10.
606 The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development.Blood Adv. 2019 Aug 13;3(15):2388-2399. doi: 10.1182/bloodadvances.2019000554.
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609 Knockdown of immature colon carcinoma transcript1 induces suppression of proliferation, S-phase arrest and apoptosis in leukemia cells.Oncol Rep. 2018 Mar;39(3):1269-1275. doi: 10.3892/or.2018.6185. Epub 2018 Jan 3.
610 A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy.Ann Pharmacother. 2020 Jan;54(1):29-35. doi: 10.1177/1060028019870445. Epub 2019 Aug 15.
611 Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis.Blood. 2008 Apr 15;111(8):4322-8. doi: 10.1182/blood-2007-06-095075. Epub 2008 Jan 2.
612 Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population.Eur J Haematol. 2011 Mar;86(3):199-205. doi: 10.1111/j.1600-0609.2010.01562.x. Epub 2011 Jan 25.
613 Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia.Carcinogenesis. 2002 Apr;23(4):559-64. doi: 10.1093/carcin/23.4.559.
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615 The nuclear migration gene NudC and human hematopoiesis.Leuk Lymphoma. 2000 Nov;39(5-6):447-54. doi: 10.3109/10428190009113375.
616 Knockdown of NUDT21 inhibits proliferation and promotes apoptosis of human K562 leukemia cells through ERK pathway.Cancer Manag Res. 2018 Oct 8;10:4311-4323. doi: 10.2147/CMAR.S173496. eCollection 2018.
617 Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice.Sci Rep. 2019 Nov 20;9(1):17213. doi: 10.1038/s41598-019-53610-7.
618 Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia.Genes Chromosomes Cancer. 2020 Feb;59(2):125-130. doi: 10.1002/gcc.22808. Epub 2019 Oct 4.
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620 Myeloid neoplasms with eosinophilia.Blood. 2017 Feb 9;129(6):704-714. doi: 10.1182/blood-2016-10-695973. Epub 2016 Dec 27.
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622 A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia.Haematologica. 2007 Jun;92(6):744-52. doi: 10.3324/haematol.10869.
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624 DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells.Int J Cancer. 2007 Aug 15;121(4):706-13. doi: 10.1002/ijc.22634.
625 ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c-Myc expression via signal transducer and activator of transcription 5 activation in the acute promyelocytic leukemia cell line HT93A.Leuk Lymphoma. 2015;56(8):2416-23. doi: 10.3109/10428194.2014.982643. Epub 2014 Dec 4.
626 FAS and RAS related Apoptosis defects: From autoimmunity to leukemia.Immunol Rev. 2019 Jan;287(1):50-61. doi: 10.1111/imr.12720.
627 S100A16 suppresses the growth and survival of leukaemia cellsand correlates with relapse and relapse free survival in adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia.Br J Haematol. 2019 Jun;185(5):836-851. doi: 10.1111/bjh.15878. Epub 2019 Mar 27.
628 Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.Genes Dev. 2011 May 1;25(9):917-29. doi: 10.1101/gad.623011.
629 Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture.Anticancer Res. 2002 Nov-Dec;22(6C):4211-4.
630 FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23).Leukemia. 2004 May;18(5):998-1005. doi: 10.1038/sj.leu.2403334.
631 Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5.mBio. 2019 Jun 11;10(3):e01071-19. doi: 10.1128/mBio.01071-19.
632 SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.Nat Commun. 2018 Jun 6;9(1):2192. doi: 10.1038/s41467-018-04462-8.
633 The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia.Leuk Lymphoma. 2017 Oct;58(10):2419-2425. doi: 10.1080/10428194.2017.1295142. Epub 2017 Feb 28.
634 CD33 (Siglec-3) Inhibitory Function: Role in the NKG2D/DAP10 Activating Pathway.J Immunol Res. 2019 Apr 15;2019:6032141. doi: 10.1155/2019/6032141. eCollection 2019.
635 Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene.Int J Oncol. 2006 Apr;28(4):899-908.
636 The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia.Biomed Res Int. 2015;2015:347571. doi: 10.1155/2015/347571. Epub 2015 Feb 19.
637 Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis.Clin Chim Acta. 2012 Aug 16;413(15-16):1211-6. doi: 10.1016/j.cca.2012.03.020. Epub 2012 Apr 3.
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639 High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.Haematologica. 2020 Jan 31;105(2):435-447. doi: 10.3324/haematol.2019.216986. Print 2020.
640 Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.Nat Genet. 2017 Jun;49(6):866-875. doi: 10.1038/ng.3854. Epub 2017 Apr 24.
641 The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.Leukemia. 2018 Sep;32(9):1984-1993. doi: 10.1038/s41375-018-0046-8. Epub 2018 Mar 20.
642 MicroRNA-124 represses wound healing by targeting SERP1 and inhibiting the Wnt/-catenin pathway.Adv Clin Exp Med. 2019 Jun;28(6):711-718. doi: 10.17219/acem/94163.
643 Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties.ACS Chem Biol. 2019 Sep 20;14(9):2071-2087. doi: 10.1021/acschembio.9b00593. Epub 2019 Aug 21.
644 Acute myeloid leukaemia: recent data on prognostic gene mutations, in relation to stratified therapies for elderly patients.J BUON. 2019 Jul-Aug;24(4):1326-1339.
645 STIP Regulates ERK1/2 Signaling Pathway Involved in Interaction with PP1 in Lymphoblastic Leukemia.Curr Mol Med. 2016;16(8):767-775. doi: 10.2174/1566524016666161018154401.
646 Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia.Leukemia. 2015 Dec;29(12):2317-27. doi: 10.1038/leu.2015.162. Epub 2015 Jun 25.
647 Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA.J Virol. 2019 Sep 30;93(20):e00364-19. doi: 10.1128/JVI.00364-19. Print 2019 Oct 15.
648 TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia.Ann Hum Genet. 2004 Jul;68(Pt 4):362-6. doi: 10.1046/j.1529-8817.2004.00101.x.
649 Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure.PLoS One. 2013 Nov 27;8(11):e80193. doi: 10.1371/journal.pone.0080193. eCollection 2013.
650 Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-B and -catenin/TCF signaling pathways.Cell Death Dis. 2018 Apr 1;9(4):427. doi: 10.1038/s41419-018-0440-1.
651 Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia.J Hematol Oncol. 2017 Jul 11;10(1):138. doi: 10.1186/s13045-017-0507-y.
652 Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.Cancer Res. 2010 Jun 15;70(12):4949-60. doi: 10.1158/0008-5472.CAN-09-1962. Epub 2010 May 25.
653 NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.Mol Cell. 2015 Dec 17;60(6):847-59. doi: 10.1016/j.molcel.2015.10.033. Epub 2015 Nov 25.
654 Analysis of CD137 and CD137L expression in human primary tumor tissues.Croat Med J. 2008 Apr;49(2):192-200. doi: 10.3325/cmj.2008.2.192.
655 A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells.BMC Cancer. 2015 Sep 7;15:621. doi: 10.1186/s12885-015-1639-5.
656 ADCY7 supports development of acute myeloid leukemia.Biochem Biophys Res Commun. 2015 Sep 11;465(1):47-52. doi: 10.1016/j.bbrc.2015.07.123. Epub 2015 Jul 26.
657 The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.Mol Cell Biol. 2012 Jul;32(13):2608-17. doi: 10.1128/MCB.00182-12. Epub 2012 Apr 30.
658 METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification.Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28.
659 ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.Cancer Discov. 2016 Jul;6(7):770-83. doi: 10.1158/2159-8290.CD-16-0058. Epub 2016 May 6.
660 ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.Nat Commun. 2017 May 18;8:15429. doi: 10.1038/ncomms15429.
661 Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Blood. 2012 Aug 16;120(7):1473-84. doi: 10.1182/blood-2011-12-395335. Epub 2012 Jun 26.
662 p130Cas acts as survival factor during PMA-induced apoptosis in HL-60 promyelocytic leukemia cells.Int J Biochem Cell Biol. 2013 Mar;45(3):531-5. doi: 10.1016/j.biocel.2012.12.017. Epub 2012 Dec 31.
663 Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.Int J Oncol. 2015 Aug;47(2):473-80. doi: 10.3892/ijo.2015.3028. Epub 2015 Jun 4.
664 The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia.Oncogene. 2018 Jan 25;37(4):450-460. doi: 10.1038/onc.2017.337. Epub 2017 Sep 25.
665 CEMP1 Induces Transformation in Human Gingival Fibroblasts.PLoS One. 2015 May 26;10(5):e0127286. doi: 10.1371/journal.pone.0127286. eCollection 2015.
666 D40/KNL1/CASC5 and autosomal recessive primary microcephaly.Congenit Anom (Kyoto). 2017 Nov;57(6):191-196. doi: 10.1111/cga.12252. Epub 2017 Nov 1.
667 DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection.mBio. 2018 Jun 5;9(3):e00923-18. doi: 10.1128/mBio.00923-18.
668 Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells.Sci Rep. 2015 Nov 18;5:16709. doi: 10.1038/srep16709.
669 Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells.Molecules. 2017 Jan 23;22(1):187. doi: 10.3390/molecules22010187.
670 DACT1 overexpression inhibits proliferation, enhances apoptosis, and increases daunorubicin chemosensitivity in KG-1 cells.Tumour Biol. 2017 Oct;39(10):1010428317711089. doi: 10.1177/1010428317711089.
671 Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models.Metallomics. 2017 Mar 22;9(3):309-322. doi: 10.1039/c6mt00226a.
672 Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.J Med Chem. 2018 Jul 26;61(14):6110-6120. doi: 10.1021/acs.jmedchem.8b00483. Epub 2018 Jul 17.
673 Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.Tumour Biol. 2016 Sep;37(9):11947-11957. doi: 10.1007/s13277-016-5039-5. Epub 2016 Apr 16.
674 Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.J Virol. 2017 Apr 28;91(10):e00129-17. doi: 10.1128/JVI.00129-17. Print 2017 May 15.
675 Effect of EPH-ephrin signaling on the growth of human leukemia cells.Anticancer Res. 2014 Jun;34(6):2913-8.
676 An ERG Enhancer-Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation.Cancer Res. 2019 Aug 1;79(15):3862-3876. doi: 10.1158/0008-5472.CAN-18-3215. Epub 2019 Jun 7.
677 Active Chest Tube Clearance After Cardiac Surgery Is Associated With Reduced Reexploration Rates.Ann Thorac Surg. 2018 Jun;105(6):1771-1777. doi: 10.1016/j.athoracsur.2018.01.002. Epub 2018 Jan 31.
678 Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.Cancer Cell. 2010 Oct 19;18(4):341-52. doi: 10.1016/j.ccr.2010.09.008.
679 Clinical features and outcome of hepatosplenic fungal infections in children with haematological malignancies.Mycoses. 2020 Jan;63(1):30-37. doi: 10.1111/myc.13002. Epub 2019 Nov 13.
680 MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice.Cancer Cell. 2003 Feb;3(2):161-71. doi: 10.1016/s1535-6108(03)00019-9.
681 Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors-Brief Report.Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2191-2197. doi: 10.1161/ATVBAHA.118.310870.
682 An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia.Oncogene. 2017 Oct 26;36(43):5985-5994. doi: 10.1038/onc.2017.210. Epub 2017 Jun 26.
683 The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.PLoS One. 2015 Jul 6;10(7):e0131716. doi: 10.1371/journal.pone.0131716. eCollection 2015.
684 Grb10 is involved in BCR-ABL-positive leukemia in mice.Leukemia. 2015 Apr;29(4):858-68. doi: 10.1038/leu.2014.283. Epub 2014 Sep 24.
685 Novel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecycles.Virology. 2016 Jul;494:129-42. doi: 10.1016/j.virol.2016.04.012. Epub 2016 Apr 22.
686 BOLA-DRB3 gene polymorphisms influence bovine leukaemia virus infection levels in Holstein and HolsteinJersey crossbreed dairy cattle.Anim Genet. 2017 Aug;48(4):420-430. doi: 10.1111/age.12566. Epub 2017 May 31.
687 Ibrutinib: A Review in Chronic Lymphocytic Leukaemia.Drugs. 2017 Feb;77(2):225-236. doi: 10.1007/s40265-017-0695-3.
688 Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells.Cell Death Dis. 2017 May 4;8(5):e2765. doi: 10.1038/cddis.2017.159.
689 INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.J Exp Clin Cancer Res. 2018 Jan 17;37(1):8. doi: 10.1186/s13046-018-0675-9.
690 JAM-C Identifies Src Family Kinase-Activated Leukemia-Initiating Cells and Predicts Poor Prognosis in Acute Myeloid Leukemia.Cancer Res. 2017 Dec 1;77(23):6627-6640. doi: 10.1158/0008-5472.CAN-17-1223. Epub 2017 Sep 28.
691 Generation and preclinical characterization of an NKp80-Fc fusion protein for redirected cytolysis of natural killer (NK) cells against leukemia.J Biol Chem. 2015 Sep 11;290(37):22474-84. doi: 10.1074/jbc.M115.678912. Epub 2015 Jul 21.
692 Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia.Exp Biol Med (Maywood). 2015 Jan;240(1):128-34. doi: 10.1177/1535370214543067. Epub 2014 Jul 17.
693 c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.Mol Cancer Res. 2015 Apr;13(4):699-712. doi: 10.1158/1541-7786.MCR-14-0422. Epub 2015 Mar 31.
694 Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines.Biochim Biophys Acta. 2014;1839(4):265-74. doi: 10.1016/j.bbagrm.2014.02.004. Epub 2014 Feb 13.
695 Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.Int Immunopharmacol. 2006 Dec 20;6(13-14):1993-2001. doi: 10.1016/j.intimp.2006.09.015. Epub 2006 Oct 17.
696 Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity.PLoS One. 2014 Mar 27;9(3):e92706. doi: 10.1371/journal.pone.0092706. eCollection 2014.
697 Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.Biochem Biophys Res Commun. 2017 Mar 18;484(4):884-889. doi: 10.1016/j.bbrc.2017.02.018. Epub 2017 Feb 8.
698 Targeting MTHFD2 in acute myeloid leukemia.J Exp Med. 2016 Jun 27;213(7):1285-306. doi: 10.1084/jem.20151574. Epub 2016 Jun 20.
699 Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia.Oncotarget. 2015 Dec 8;6(39):42300-11. doi: 10.18632/oncotarget.5982.
700 Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer.J Cell Biochem. 2015 Oct;116(10):2146-54. doi: 10.1002/jcb.25203.
701 Necdin modulates leukemia-initiating cell quiescence and chemotherapy response.Oncotarget. 2017 Sep 18;8(50):87607-87622. doi: 10.18632/oncotarget.20999. eCollection 2017 Oct 20.
702 DNAM-1-based chimeric antigen receptors enhance T cell effector function and exhibit in vivo efficacy against melanoma.Cancer Immunol Immunother. 2015 Apr;64(4):409-18. doi: 10.1007/s00262-014-1648-2. Epub 2014 Dec 31.
703 Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs.Pharmacogenet Genomics. 2016 Jun;26(6):271-9. doi: 10.1097/FPC.0000000000000208.
704 Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15(R138C) knock-in mice.Leukemia. 2020 Mar;34(3):882-894. doi: 10.1038/s41375-019-0583-9. Epub 2019 Oct 24.
705 Circulating tight junction proteins mirror blood-brain barrier integrity in leukaemia central nervous system metastasis.Hematol Oncol. 2017 Sep;35(3):365-373. doi: 10.1002/hon.2289. Epub 2016 Mar 21.
706 RKTG overexpression inhibits proliferation and induces apoptosis of human leukemia cells via suppression of the ERK and PI3K/AKT signaling pathways.Oncol Lett. 2017 Jul;14(1):965-970. doi: 10.3892/ol.2017.6182. Epub 2017 May 17.
707 Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth.J Biol Chem. 2014 Aug 1;289(31):21413-22. doi: 10.1074/jbc.M114.581124. Epub 2014 Jun 24.
708 Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.JCI Insight. 2018 Oct 18;3(20):e123172. doi: 10.1172/jci.insight.123172.
709 NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.Cancer Discov. 2014 May;4(5):564-77. doi: 10.1158/2159-8290.CD-13-0419. Epub 2014 Feb 17.
710 The regulation of tumor-suppressive microRNA, miR-126, inchronic lymphocytic leukemia.Cancer Med. 2017 Apr;6(4):778-787. doi: 10.1002/cam4.996. Epub 2017 Mar 15.
711 The miR-17?2 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.Leuk Res. 2016 Jul;46:51-60. doi: 10.1016/j.leukres.2016.04.006. Epub 2016 Apr 16.
712 PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.Cell Rep. 2018 May 1;23(5):1461-1475. doi: 10.1016/j.celrep.2018.03.140.
713 Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Blood. 2013 Aug 15;122(7):1293-304. doi: 10.1182/blood-2013-05-501072. Epub 2013 Jul 8.
714 High Level of Perforin Expression Is Required for Effective Correction of Hemophagocytic Lymphohistiocytosis.Hum Gene Ther. 2016 Oct;27(10):847-859. doi: 10.1089/hum.2016.065. Epub 2016 Jul 29.
715 Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion.Leukemia. 2018 Mar;32(3):575-587. doi: 10.1038/leu.2017.259. Epub 2017 Aug 17.
716 Modulating the Growth and Imatinib Sensitivity of Chronic Myeloid Leukemia Stem/Progenitor Cells with Pullulan/MicroRNA Nanoparticles In Vitro.J Biomed Nanotechnol. 2015 Nov;11(11):1961-74. doi: 10.1166/jbn.2015.2147.
717 A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation.Br J Nutr. 2017 Oct;118(8):580-588. doi: 10.1017/S0007114517002501.
718 Steps solidifying a role for SEPT9 in breast cancer suggest that greater strides are needed.Breast Cancer Res. 2012 Jan 9;14(1):101. doi: 10.1186/bcr3056.
719 SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.Haematologica. 2014 Aug;99(8):1356-64. doi: 10.3324/haematol.2013.100230. Epub 2014 May 23.
720 Embryonic stem cell derived germ cells induce spermatogenesis after transplantation into the testes of an adult mouse azoospermia model.Clin Sci (Lond). 2017 Sep 8;131(18):2381-2395. doi: 10.1042/CS20171074. Print 2017 Sep 15.
721 SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma.Clin Cancer Res. 2015 Sep 15;21(18):4184-93. doi: 10.1158/1078-0432.CCR-14-2112. Epub 2015 Mar 16.
722 SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia.Oncogene. 2015 Jan 29;34(5):631-8. doi: 10.1038/onc.2013.587. Epub 2014 Jan 27.
723 STAG2 loss-of-function mutation induces PD-L1 expression in U2OS cells.Ann Transl Med. 2019 Apr;7(7):127. doi: 10.21037/atm.2019.02.23.
724 Signalling strength determines proapoptotic functions of STING.Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w.
725 The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23.
726 Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.Cancer Lett. 2017 Feb 1;386:131-140. doi: 10.1016/j.canlet.2016.11.021. Epub 2016 Nov 25.
727 Investigating CD99 Expression in Leukemia Propagating Cells in Childhood T Cell Acute Lymphoblastic Leukemia.PLoS One. 2016 Oct 20;11(10):e0165210. doi: 10.1371/journal.pone.0165210. eCollection 2016.
728 Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice.Am J Pathol. 2018 Jun;188(6):1457-1468. doi: 10.1016/j.ajpath.2018.02.015. Epub 2018 Mar 21.
729 Overexpression of feline tripartite motif-containing 25 interferes with the late stage of feline leukemia virus replication.Virus Res. 2015 Jun 2;204:88-94. doi: 10.1016/j.virusres.2015.04.017. Epub 2015 Apr 24.
730 Cellular uptake and antiproliferative effects of therapeutic concentrations of idarubicin or daunorubicin and their alcohol metabolites, with or without cyclosporin A, in MDR1+ human leukemic cells.Leuk Lymphoma. 1999 May;33(5-6):485-97. doi: 10.3109/10428199909058453.
731 Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins.J Biol Chem. 2002 Mar 29;277(13):11247-54. doi: 10.1074/jbc.M109519200. Epub 2002 Jan 8.
732 O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia.J Exp Med. 2013 Apr 8;210(4):805-19. doi: 10.1084/jem.20121482. Epub 2013 Mar 11.
733 Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.Nat Commun. 2017 May 31;8:15580. doi: 10.1038/ncomms15580.
734 Differential expression of protein tyrosine phosphatase genes during phorbol ester-induced differentiation of human leukemia U937 cells.Cell Growth Differ. 1993 Dec;4(12):1033-9.
735 Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.Clin Cancer Res. 2018 Nov 1;24(21):5321-5334. doi: 10.1158/1078-0432.CCR-18-0167. Epub 2018 Jul 24.
736 Defining the functions of adenosine-to-inosine RNA editing through hematology.Curr Opin Hematol. 2019 Jul;26(4):241-248. doi: 10.1097/MOH.0000000000000514.
737 Knockdown of Adhesion-Regulating Molecule 1 Inhibits Proliferation in HL60 Cells.Acta Haematol. 2015;134(2):88-100. doi: 10.1159/000369916. Epub 2015 Apr 21.
738 Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study.Br J Haematol. 2010 Feb;148(3):394-401. doi: 10.1111/j.1365-2141.2009.07966.x. Epub 2009 Nov 4.
739 LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.Blood. 1996 Jan 15;87(2):734-45.
740 Palmitoylation and p8-mediated human T-cell leukemia virus type 1 transmission.J Virol. 2014 Feb;88(4):2319-22. doi: 10.1128/JVI.03444-13. Epub 2013 Nov 27.
741 Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.Genes Chromosomes Cancer. 2012 May;51(5):510-20. doi: 10.1002/gcc.21939. Epub 2012 Feb 15.
742 Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10years and future perspectives.Wien Klin Wochenschr. 2018 Sep;130(17-18):517-529. doi: 10.1007/s00508-018-1355-7. Epub 2018 Jul 13.
743 Is AMN-107 a step forward from imatinib in the treatment of chronic myeloid leukaemia?.Expert Opin Investig Drugs. 2005 Aug;14(8):1063-6. doi: 10.1517/13543784.14.8.1063.
744 ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells.Biochim Biophys Acta. 2006 Sep;1762(9):828-34. doi: 10.1016/j.bbadis.2006.07.010. Epub 2006 Jul 31.
745 The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.J Alzheimers Dis. 2004 Feb;6(1):67-78. doi: 10.3233/jad-2004-6108.
746 Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.Blood. 2013 Dec 5;122(24):3960-3. doi: 10.1182/blood-2013-04-497693. Epub 2013 Oct 7.
747 Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice.FEBS Lett. 2009 Jun 18;583(12):1859-66. doi: 10.1016/j.febslet.2009.04.046. Epub 2009 May 8.
748 Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res. 2005 Jun;3(6):325-34. doi: 10.1158/1541-7786.MCR-04-0105.
749 Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation.Nat Genet. 2004 Mar;36(3):257-63. doi: 10.1038/ng1305. Epub 2004 Feb 8.
750 Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.J Mol Biol. 2009 Jan 9;385(1):65-78. doi: 10.1016/j.jmb.2008.10.043. Epub 2008 Nov 1.
751 Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.Cancer Res. 2017 Sep 1;77(17):4579-4588. doi: 10.1158/0008-5472.CAN-16-3394. Epub 2017 Jun 27.
752 The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer Res. 2004 Jan 15;64(2):728-35.
753 Species-specific restriction of apobec3-mediated hypermutation.J Virol. 2008 Feb;82(3):1305-13. doi: 10.1128/JVI.01371-07. Epub 2007 Nov 21.
754 Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells.Oxid Med Cell Longev. 2018 Nov 18;2018:4125297. doi: 10.1155/2018/4125297. eCollection 2018.
755 Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.J Biol Chem. 2004 Jul 9;279(28):28831-4. doi: 10.1074/jbc.C400105200. Epub 2004 May 13.
756 E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies.Cell Death Differ. 2004 Jul;11(7):747-59. doi: 10.1038/sj.cdd.4401412.
757 Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.J Biol Chem. 2012 Mar 9;287(11):8531-40. doi: 10.1074/jbc.M111.299149. Epub 2012 Jan 12.
758 ARID4B is a good biomarker to predict tumour behaviour and decide WHO grades in gliomas and meningiomas.J Clin Pathol. 2017 Feb;70(2):162-167. doi: 10.1136/jclinpath-2016-203804. Epub 2016 Jul 22.
759 Argininosuccinate synthetase gene expression in leukemias: potential diagnostic marker for blastic crisis of chronic myelocytic leukemia.Leuk Res. 1992;16(5):475-83. doi: 10.1016/0145-2126(92)90173-5.
760 RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.J Hematol Oncol. 2019 Oct 22;12(1):104. doi: 10.1186/s13045-019-0789-3.
761 Genetic control and dynamics of the cellular immune response to the human T-cell leukaemia virus, HTLV-I.Philos Trans R Soc Lond B Biol Sci. 1999 Apr 29;354(1384):691-700. doi: 10.1098/rstb.1999.0422.
762 Atg3 Overexpression Enhances Bortezomib-Induced Cell Death in SKM-1 Cell.PLoS One. 2016 Jul 8;11(7):e0158761. doi: 10.1371/journal.pone.0158761. eCollection 2016.
763 Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukaemia cells.Biochem Biophys Res Commun. 2004 Oct 1;322(4):1223-36. doi: 10.1016/j.bbrc.2004.08.030.
764 Patient mutations alter ATRX targeting to PML nuclear bodies.Eur J Hum Genet. 2008 Feb;16(2):192-201. doi: 10.1038/sj.ejhg.5201943. Epub 2007 Oct 24.
765 Dasatinib-induced anti-leukemia cellular immunity through a novel subset of CD57 positive helper/cytotoxic CD4 T cells in chronic myelogenous leukemia patients.Int J Hematol. 2018 Dec;108(6):588-597. doi: 10.1007/s12185-018-2517-0. Epub 2018 Aug 27.
766 B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.Cell Death Dis. 2013 Jun 6;4(6):e654. doi: 10.1038/cddis.2013.186.
767 B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line.IUBMB Life. 2012 Nov;64(11):889-900. doi: 10.1002/iub.1080. Epub 2012 Sep 29.
768 Histone post-translational modifications associated to BAALC expression in leukemic cells.Biochem Biophys Res Commun. 2012 Jan 13;417(2):721-5. doi: 10.1016/j.bbrc.2011.12.013. Epub 2011 Dec 14.
769 Identification of IGHC-BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B-cell lymphoma/leukemia.Genes Chromosomes Cancer. 2011 Apr;50(4):207-16. doi: 10.1002/gcc.20845. Epub 2011 Jan 13.
770 BAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia.PLoS One. 2011;6(10):e26097. doi: 10.1371/journal.pone.0026097. Epub 2011 Oct 10.
771 A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.Cancer Genet Cytogenet. 2004 Feb;149(1):72-6. doi: 10.1016/s0165-4608(03)00302-9.
772 Molecular analysis of the BCL-3 locus at chromosome 17q22 in B-cell neoplasms.Blood. 1993 Sep 15;82(6):1813-9.
773 Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis.Nat Commun. 2019 Mar 22;10(1):1347. doi: 10.1038/s41467-019-09250-6.
774 Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia.Tumour Biol. 2017 Oct;39(10):1010428317720643. doi: 10.1177/1010428317720643.
775 Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/Abl+ leukemic cells.Carcinogenesis. 2009 Jan;30(1):35-42. doi: 10.1093/carcin/bgn251. Epub 2008 Nov 21.
776 Epigenetic regulation of brain expressed X-linked-2, a marker for acute myeloid leukemia with mixed lineage leukemia rearrangements.Leukemia. 2007 Feb;21(2):374-7. doi: 10.1038/sj.leu.2404493.
777 JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia.Oncogene. 1997 Apr 3;14(13):1563-70. doi: 10.1038/sj.onc.1200995.
778 Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.Oncogene. 2003 Jul 24;22(30):4679-89. doi: 10.1038/sj.onc.1206624.
779 MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.Oncogene. 1993 Nov;8(11):3085-92.
780 Leukemia-associated gene MLAA-34 reduces arsenic trioxide-induced apoptosis in HeLa cells via activation of the Wnt/-catenin signaling pathway.PLoS One. 2017 Oct 23;12(10):e0186868. doi: 10.1371/journal.pone.0186868. eCollection 2017.
781 A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.Cell Signal. 2015 Feb;27(2):204-14. doi: 10.1016/j.cellsig.2014.11.007. Epub 2014 Nov 15.
782 CAML promotes prolactin-dependent proliferation of breast cancer cells by facilitating prolactin receptor signaling pathways.Breast Cancer Res Treat. 2011 Nov;130(1):19-27. doi: 10.1007/s10549-010-1274-4. Epub 2010 Dec 3.
783 The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.BMC Mol Biol. 2012 Mar 23;13:11. doi: 10.1186/1471-2199-13-11.
784 The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.Mol Cancer Res. 2019 Jul;17(7):1468-1479. doi: 10.1158/1541-7786.MCR-18-1327. Epub 2019 Apr 23.
785 Targeting a mitochondrial potassium channel to fight cancer.Cell Calcium. 2015 Jul;58(1):131-8. doi: 10.1016/j.ceca.2014.09.006. Epub 2014 Oct 18.
786 WT1 regulates cyclinA1 expression in K562cells.Oncol Rep. 2019 Nov;42(5):2016-2028. doi: 10.3892/or.2019.7287. Epub 2019 Aug 21.
787 A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.J Exp Med. 2014 Jun 30;211(7):1363-77. doi: 10.1084/jem.20140410. Epub 2014 Jun 16.
788 Upregulated TCR enhances interleukin-2 production in T-cells from patients with CML.DNA Cell Biol. 2012 Nov;31(11):1628-35. doi: 10.1089/dna.2012.1798. Epub 2012 Oct 11.
789 TGF- regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression.Immunobiology. 2019 Sep;224(5):649-658. doi: 10.1016/j.imbio.2019.07.002. Epub 2019 Aug 9.
790 CD82 supports survival of childhood acute myeloid leukemia cells via activation of Wnt/-catenin signaling pathway.Pediatr Res. 2019 Jun;85(7):1024-1031. doi: 10.1038/s41390-019-0370-3. Epub 2019 Mar 12.
791 Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14.Genomics. 2000 Dec 15;70(3):327-34. doi: 10.1006/geno.2000.6386.
792 Clinical and preclinical characterization of CD99 isoforms in acute myeloid leukemia.Haematologica. 2020 Apr;105(4):999-1012. doi: 10.3324/haematol.2018.207001. Epub 2019 Aug 1.
793 Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.Cell Growth Differ. 2001 Aug;12(8):427-33.
794 Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16924-9. doi: 10.1073/pnas.0604579103. Epub 2006 Oct 26.
795 A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.Cancer Cell. 2018 Nov 12;34(5):707-723.e7. doi: 10.1016/j.ccell.2018.10.004.
796 Congenital heart disease complexity and childhood cancer risk.Birth Defects Res. 2018 Oct 16;110(17):1314-1321. doi: 10.1002/bdr2.1390. Epub 2018 Oct 16.
797 Silencing of CHD5 gene by promoter methylation in leukemia.PLoS One. 2014 Jan 13;9(1):e85172. doi: 10.1371/journal.pone.0085172. eCollection 2014.
798 Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.Blood. 2012 Oct 25;120(17):3491-500. doi: 10.1182/blood-2012-02-412643. Epub 2012 Sep 6.
799 Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).Blood. 1999 Sep 1;94(5):1820-4.
800 PNAS-2: a novel gene probably participating in leukemogenesis.Oncology. 2006;71(5-6):423-9. doi: 10.1159/000108576. Epub 2007 Sep 14.
801 Lack of BLV and PTLV DNA sequences in the majority of patients with large granular lymphocyte leukaemia.Br J Haematol. 2000 Apr;109(1):64-70. doi: 10.1046/j.1365-2141.2000.01972.x.
802 Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells.Exp Hematol. 2014 Sep;42(9):783-92.e1. doi: 10.1016/j.exphem.2014.05.007. Epub 2014 May 23.
803 RHOA, SEMA3B, and CKAP2 expression in leukaemia of different types: the results of a pilot experiment.Folia Biol (Praha). 2013;59(5):204-6.
804 Increased creatine kinase BB activity and CKB mRNA expression in patients with hematologic disorders: relation to methylation status of the CKB promoter.Clin Chim Acta. 2005 Nov;361(1-2):135-40. doi: 10.1016/j.cccn.2005.05.028.
805 CLCA2, a novel RUNX1 partner gene in a therapy-related leukemia with t(1;21)(p22;q22).Cancer Genet Cytogenet. 2010 Oct 15;202(2):94-100. doi: 10.1016/j.cancergencyto.2010.07.116.
806 Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes.J Allergy Clin Immunol. 2010 Mar;125(3):719-26, 726.e1-726.e4. doi: 10.1016/j.jaci.2009.10.020. Epub 2010 Jan 12.
807 Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias.Blood. 1994 Jun 15;83(12):3689-96.
808 Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia.Leuk Res. 2011 Jun;35(6):771-6. doi: 10.1016/j.leukres.2010.11.023. Epub 2010 Dec 18.
809 BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.Oncogene. 2002 May 9;21(20):3225-31. doi: 10.1038/sj.onc.1205452.
810 Interactions between coilin and PIASy partially link Cajal bodies to PML bodies.J Cell Sci. 2005 Nov 1;118(Pt 21):4995-5003. doi: 10.1242/jcs.02613. Epub 2005 Oct 11.
811 Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial.J Clin Oncol. 2011 Jun 1;29(16):2223-9. doi: 10.1200/JCO.2010.32.0838. Epub 2011 Apr 11.
812 CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.BMC Cancer. 2019 May 27;19(1):499. doi: 10.1186/s12885-019-5671-8.
813 CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia.J Exp Med. 2009 Apr 13;206(4):779-91. doi: 10.1084/jem.20081922. Epub 2009 Apr 6.
814 Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies.Cancer Res. 2009 Nov 1;69(21):8482-90. doi: 10.1158/0008-5472.CAN-09-1153. Epub 2009 Oct 13.
815 CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.Blood. 2013 Feb 7;121(6):975-83. doi: 10.1182/blood-2012-04-426965. Epub 2012 Dec 3.
816 Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.Mol Pharmacol. 2006 Sep;70(3):897-908. doi: 10.1124/mol.106.023937. Epub 2006 Jun 5.
817 Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells.J Clin Invest. 1989 May;83(5):1570-9. doi: 10.1172/JCI114054.
818 Intraplatform reproducibility and technical precision of gene expression profiling in 4 laboratories investigating 160 leukemia samples: the DACH study.Clin Chem. 2008 Oct;54(10):1705-15. doi: 10.1373/clinchem.2008.108506. Epub 2008 Aug 21.
819 Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection.J Virol. 2008 Jan;82(1):126-37. doi: 10.1128/JVI.01685-07. Epub 2007 Oct 17.
820 From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488. doi: 10.1002/anie.201510610. Epub 2016 Nov 15.
821 Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical.Blood. 2007 Oct 1;110(7):2569-77. doi: 10.1182/blood-2006-12-062927. Epub 2007 Apr 17.
822 Novel DDX41 variants in Thai patients with myeloid neoplasms.Int J Hematol. 2020 Feb;111(2):241-246. doi: 10.1007/s12185-019-02770-3. Epub 2019 Nov 11.
823 Frequent expression of HAGE in presentation chronic myeloid leukaemias.Leukemia. 2002 Nov;16(11):2238-42. doi: 10.1038/sj.leu.2402732.
824 Glucocorticoid resistance in childhood leukemia.Leuk Lymphoma. 1994 Apr;13(3-4):187-201. doi: 10.3109/10428199409056282.
825 The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia.Leuk Res. 2002 Oct;26(10):945-54. doi: 10.1016/s0145-2126(02)00040-1.
826 Crosslineage TCR delta rearrangements occur shortly after the DJ joinings of the IgH genes in childhood precursor B ALL and display age-specific characteristics.Br J Haematol. 1997 Oct;99(1):115-21. doi: 10.1046/j.1365-2141.1997.3653179.x.
827 Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration. Proc Natl Acad Sci U S A. 1999 Nov23;96(24):13989-94.
828 Down-regulation of DLX3 expression in MLL-AF4 childhood lymphoblastic leukemias is mediated by promoter region hypermethylation.Oncol Rep. 2007 Aug;18(2):417-23.
829 BP1, a new homeobox gene, is frequently expressed in acute leukemias.Leukemia. 2000 Nov;14(11):1867-75. doi: 10.1038/sj.leu.2401912.
830 Silencing of DMBT1 in neuroblastoma cell lines is not due to methylation of CCWGG motifs on its promoter.Neoplasma. 2006;53(1):15-8.
831 ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia.Oncogene. 2014 Nov 27;33(48):5501-10. doi: 10.1038/onc.2013.501. Epub 2013 Dec 2.
832 BET inhibitors impair leukemic stem cell function only in defined oncogenic subgroups of acute myeloid leukaemias.Leuk Res. 2019 Dec;87:106269. doi: 10.1016/j.leukres.2019.106269. Epub 2019 Nov 7.
833 DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.Blood. 2002 Dec 1;100(12):3968-74. doi: 10.1182/blood-2001-11-0032. Epub 2002 Jun 28.
834 Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia.J Cell Physiol. 2018 Sep;233(9):6604-6614. doi: 10.1002/jcp.26271. Epub 2018 Mar 14.
835 All-trans retinoic acid induces p62DOK1 and p56DOK2 expression which enhances induced differentiation and G0 arrest of HL-60 leukemia cells.Am J Hematol. 2006 Aug;81(8):603-15. doi: 10.1002/ajh.20667.
836 Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10980-5. doi: 10.1073/pnas.0704559104. Epub 2007 Jun 20.
837 Characterization of a variant of PAC-1 in large granular lymphocyte leukemia.Protein Expr Purif. 2003 Nov;32(1):52-60. doi: 10.1016/S1046-5928(03)00237-7.
838 ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia.Mol Biol Cell. 2003 Apr;14(4):1517-28. doi: 10.1091/mbc.e02-07-0394.
839 Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma.World J Gastroenterol. 2004 Aug 1;10(15):2232-40. doi: 10.3748/wjg.v10.i15.2232.
840 Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia.Blood. 2010 Mar 25;115(12):2412-9. doi: 10.1182/blood-2009-05-222208. Epub 2010 Jan 8.
841 Megakaryocyte-derived excessive transforming growth factor 1 inhibits proliferation of normal hematopoietic stem cells in acute myeloid leukemia.Exp Hematol. 2018 Apr;60:40-46.e2. doi: 10.1016/j.exphem.2017.12.010. Epub 2018 Jan 4.
842 Electrochemical branched-DNA assay for polymerase chain reaction-free detection and quantification of oncogenes in messenger RNA.Anal Chem. 2008 Dec 15;80(24):9402-10. doi: 10.1021/ac801263r.
843 Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.Mol Cell Biochem. 2018 Jan;438(1-2):191-198. doi: 10.1007/s11010-017-3127-5. Epub 2017 Aug 12.
844 A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.Open Biol. 2014 Nov;4(11):140180. doi: 10.1098/rsob.140180.
845 The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections.J Virol. 2008 Jun;82(12):5860-8. doi: 10.1128/JVI.00076-08. Epub 2008 Apr 9.
846 Realgar transforming solution as a novel arsenic agent with a lower risk of cardiotoxicity.J Pharmacol Sci. 2019 Jun;140(2):162-170. doi: 10.1016/j.jphs.2019.06.003. Epub 2019 Jun 15.
847 Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.Leukemia. 2014 May;28(5):1081-91. doi: 10.1038/leu.2013.316. Epub 2013 Oct 29.
848 ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias.Exp Hematol. 2016 Apr;44(4):269-81.e1. doi: 10.1016/j.exphem.2015.12.010. Epub 2016 Jan 14.
849 Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay.PLoS One. 2015 Aug 12;10(8):e0133769. doi: 10.1371/journal.pone.0133769. eCollection 2015.
850 The ETS factor TEL2 is a hematopoietic oncoprotein.Blood. 2006 Feb 1;107(3):1124-32. doi: 10.1182/blood-2005-03-1196. Epub 2005 Oct 18.
851 Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.Blood. 2010 Feb 25;115(8):1610-20. doi: 10.1182/blood-2009-07-232249. Epub 2009 Dec 14.
852 Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia.Tumour Biol. 2018 Apr;40(4):1010428318771472. doi: 10.1177/1010428318771472.
853 EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.Cancer Sci. 2016 Dec;107(12):1745-1754. doi: 10.1111/cas.13080. Epub 2016 Nov 25.
854 Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.Hum Mol Genet. 2004 Nov 15;13(22):2753-65. doi: 10.1093/hmg/ddh298. Epub 2004 Sep 22.
855 Discussing and managing hematologic germ line variants.Blood. 2016 Nov 24;128(21):2497-2503. doi: 10.1182/blood-2016-06-716704.
856 Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.Cell Oncol. 2008;30(4):299-306. doi: 10.3233/clo-2008-0426.
857 Loss of FBXO9 Enhances Proteasome Activity and Promotes Aggressiveness in Acute Myeloid Leukemia.Cancers (Basel). 2019 Nov 3;11(11):1717. doi: 10.3390/cancers11111717.
858 Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells.Blood. 2002 Sep 15;100(6):2138-44. doi: 10.1182/blood-2001-12-0340.
859 Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells.Exp Cell Res. 2008 Jun 10;314(10):2028-39. doi: 10.1016/j.yexcr.2008.02.012. Epub 2008 Mar 4.
860 Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.J Exp Med. 2017 Mar 6;214(3):719-735. doi: 10.1084/jem.20161087. Epub 2017 Feb 15.
861 The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.J Biol Chem. 2002 Oct 4;277(40):37045-53. doi: 10.1074/jbc.M203336200. Epub 2002 Jul 26.
862 FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia.Ann Hematol. 2014 Sep;93(9):1473-81. doi: 10.1007/s00277-014-2085-1. Epub 2014 Apr 25.
863 Fli-1 promotes proliferation and upregulates NANOGP8 expression in T-lymphocyte leukemia cells.Biochimie. 2020 Jan;168:1-9. doi: 10.1016/j.biochi.2019.10.005. Epub 2019 Oct 15.
864 Frat2 mediates the oncogenic activation of Rac by MLL fusions.Blood. 2012 Dec 6;120(24):4819-28. doi: 10.1182/blood-2012-05-432534. Epub 2012 Oct 16.
865 Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.Cancer Genet Cytogenet. 2007 Sep;177(2):143-6. doi: 10.1016/j.cancergencyto.2007.05.021.
866 The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.Leukemia. 2019 Jul;33(7):1700-1712. doi: 10.1038/s41375-018-0358-8. Epub 2019 Jan 11.
867 Methylation status of the promoter region of the human frizzled 9 gene in acute myeloid leukemia.Mol Med Rep. 2016 Aug;14(2):1339-44. doi: 10.3892/mmr.2016.5387. Epub 2016 Jun 10.
868 Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Leukemia. 2017 Jun;31(6):1415-1422. doi: 10.1038/leu.2016.326. Epub 2016 Nov 14.
869 Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia.Oncotarget. 2017 Feb 14;8(7):10809-10821. doi: 10.18632/oncotarget.14580.
870 Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice.Leukemia. 2020 Mar;34(3):759-770. doi: 10.1038/s41375-019-0605-7. Epub 2019 Oct 17.
871 Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.Leukemia. 2019 Jan;33(1):110-121. doi: 10.1038/s41375-018-0166-1. Epub 2018 Jun 20.
872 A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network.Dev Biol. 2016 Mar 15;411(2):277-286. doi: 10.1016/j.ydbio.2016.02.002. Epub 2016 Feb 3.
873 Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors.Int J Mol Med. 2002 May;9(5):509-13.
874 CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.Br J Haematol. 2019 Feb;184(3):337-347. doi: 10.1111/bjh.15725. Epub 2018 Dec 28.
875 Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.J Cancer Res Clin Oncol. 2003 Feb;129(2):76-83. doi: 10.1007/s00432-002-0413-7. Epub 2003 Mar 1.
876 Nucleostemin silencing induces differentiation and potentiates all-trans-retinoic acid effects in human acute promyelocytic leukemia NB4 cells via autophagy.Leuk Res. 2017 Dec;63:15-21. doi: 10.1016/j.leukres.2017.10.007. Epub 2017 Oct 26.
877 Expression of granulysin mRNA in the human megakaryoblastic leukemia cell line CMK.Acta Haematol. 2002;108(1):13-8. doi: 10.1159/000063061.
878 The small oligomerization domain of gephyrin converts MLL to an oncogene.Blood. 2004 May 15;103(10):3876-82. doi: 10.1182/blood-2003-11-3817. Epub 2004 Jan 29.
879 ITR?84 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.Oncol Rep. 2018 Jan;39(1):383-391. doi: 10.3892/or.2017.6090. Epub 2017 Nov 9.
880 Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers.Cancer Res. 2004 Apr 1;64(7):2411-7. doi: 10.1158/0008-5472.can-03-0164.
881 Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.Mol Cancer Ther. 2018 Aug;17(8):1694-1704. doi: 10.1158/1535-7163.MCT-18-0028. Epub 2018 May 10.
882 Anti-leukemic effects of HDACi Belinostat and HMTi 3-Deazaneplanocin A on human acute promyelocytic leukemia cells.Eur J Pharmacol. 2017 Mar 15;799:143-153. doi: 10.1016/j.ejphar.2017.02.014. Epub 2017 Feb 10.
883 Rapamycin-mediated induction of gamma-globin mRNA accumulation in human erythroid cells.Br J Haematol. 2004 Aug;126(4):612-21. doi: 10.1111/j.1365-2141.2004.05083.x.
884 E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.Mol Cell. 2007 Jul 6;27(1):107-19. doi: 10.1016/j.molcel.2007.05.030.
885 EDAG-1 promotes proliferation and invasion of human thyroid cancer cells by activating MAPK/Erk and AKT signal pathways.Cancer Biol Ther. 2016 Apr 2;17(4):414-21. doi: 10.1080/15384047.2016.1156259. Epub 2016 Mar 2.
886 New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia.Br J Cancer. 2007 Apr 23;96(8):1265-71. doi: 10.1038/sj.bjc.6603706. Epub 2007 Mar 27.
887 Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.Cancer. 2013 Oct 1;119(19):3555-62. doi: 10.1002/cncr.28256. Epub 2013 Jul 16.
888 Prognostic significance of huntingtin interacting protein 1 expression on patients with acute myeloid leukemia.Sci Rep. 2017 Apr 28;7:45960. doi: 10.1038/srep45960.
889 The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.Cancer Cell. 2019 Dec 9;36(6):630-644.e9. doi: 10.1016/j.ccell.2019.10.004. Epub 2019 Nov 14.
890 The homeodomain region controls the phenotype of HOX-induced murine leukemia.Blood. 2012 Nov 8;120(19):4018-27. doi: 10.1182/blood-2011-10-384685. Epub 2012 Sep 18.
891 Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes.Blood. 1992 Jul 1;80(1):185-93.
892 Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.Blood. 2014 Sep 11;124(11):1737-47. doi: 10.1182/blood-2013-10-534735. Epub 2014 Jul 31.
893 HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.J Mol Endocrinol. 2012 Jan 25;48(1):61-75. doi: 10.1530/JME-11-0078. Print 2012 Feb.
894 Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukemias and normal myeloid cells.Leukemia. 1998 Nov;12(11):1724-32. doi: 10.1038/sj.leu.2401106.
895 Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells.Haematologica. 2002 Sep;87(9):903-7.
896 Identification of an overexpressed gene, HSPA4L, the product of which can provoke prevalent humoral immune responses in leukemia patients.Exp Hematol. 2007 Jul;35(7):1091-9. doi: 10.1016/j.exphem.2007.03.015.
897 Molecular cloning of six novel Krppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.J Biol Chem. 1999 Dec 10;274(50):35741-8. doi: 10.1074/jbc.274.50.35741.
898 Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.Nat Genet. 2005 Mar;37(3):265-74. doi: 10.1038/ng1521. Epub 2005 Feb 20.
899 Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes.Cancer Res. 2009 Oct 1;69(19):7518-23. doi: 10.1158/0008-5472.CAN-09-1428. Epub 2009 Sep 22.
900 Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.Biol Cell. 2017 Feb;109(2):94-112. doi: 10.1111/boc.201600034. Epub 2016 Oct 26.
901 RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.Leukemia. 2020 May;34(5):1354-1363. doi: 10.1038/s41375-019-0656-9. Epub 2019 Nov 25.
902 Identification of characteristic IGF2BP expression patterns in distinct B-ALL entities.Blood Cells Mol Dis. 2011 Apr 15;46(4):321-6. doi: 10.1016/j.bcmd.2011.02.005. Epub 2011 Mar 17.
903 Insulin-like growth factor-binding protein 4 in children with acute lymphoblastic leukemia.Int J Hematol. 2005 Aug;82(2):137-42. doi: 10.1532/IJH97.E0429.
904 Incontinentia pigmenti with ultrastructurally disordered leucocytes.J Clin Pathol. 2010 Jul;63(7):657-9. doi: 10.1136/jcp.2009.074203.
905 CD8?innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.Immunity. 2014 Sep 18;41(3):451-464. doi: 10.1016/j.immuni.2014.08.010. Epub 2014 Sep 11.
906 INV(12) (p13q11) and dicentric chromosomes in a secondary leukaemia with basophilia.Haematologica. 1990 Sep-Oct;75(5):473-6.
907 The role of IRF1 and IRF2 transcription factors in leukaemogenesis.Curr Gene Ther. 2006 Oct;6(5):543-50. doi: 10.2174/156652306778520683.
908 Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies.PLoS One. 2014 Sep 10;9(9):e106788. doi: 10.1371/journal.pone.0106788. eCollection 2014.
909 JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.Int J Hematol. 2015 Jul;102(1):76-85. doi: 10.1007/s12185-015-1797-x. Epub 2015 May 5.
910 The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor.Biochem J. 2003 Aug 15;374(Pt 1):165-73. doi: 10.1042/BJ20030087.
911 HBO1 is required for the maintenance of leukaemia stem cells.Nature. 2020 Jan;577(7789):266-270. doi: 10.1038/s41586-019-1835-6. Epub 2019 Dec 11.
912 Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.Cancer Res. 2017 Apr 1;77(7):1753-1762. doi: 10.1158/0008-5472.CAN-16-2374. Epub 2017 Feb 15.
913 KIR2DS5 is associated with leukemia free survival after HLA identical stem cell transplantation in chronic myeloid leukemia patients.Mol Immunol. 2008 Aug;45(13):3631-8. doi: 10.1016/j.molimm.2008.04.016. Epub 2008 Jun 16.
914 Survey and evaluation of mutations in the human KLF1 transcription unit.Sci Rep. 2018 Apr 26;8(1):6587. doi: 10.1038/s41598-018-24962-3.
915 TIEG1 deficiency confers enhanced myocardial protection in the infarcted heart by mediating the Pten/Akt signalling pathway.Int J Mol Med. 2017 Mar;39(3):569-578. doi: 10.3892/ijmm.2017.2889. Epub 2017 Feb 13.
916 Hypoxia selects for a quiescent, CML stem/leukemia initiating-like population dependent on CBP/catenin transcription.Curr Mol Pharmacol. 2013 Nov;6(3):204-10. doi: 10.2174/1874467207666140219121219.
917 The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).J Biol Chem. 2003 Apr 25;278(17):15412-20. doi: 10.1074/jbc.M300592200. Epub 2003 Feb 14.
918 miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.PLoS One. 2015 Jun 29;10(6):e0131823. doi: 10.1371/journal.pone.0131823. eCollection 2015.
919 New targets for Ph+ leukaemia therapy.Best Pract Res Clin Haematol. 2009 Sep;22(3):445-54. doi: 10.1016/j.beha.2009.08.002.
920 LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Mol Cell Biol. 2015 Nov 23;36(3):488-506. doi: 10.1128/MCB.00901-15. Print 2016 Feb 1.
921 Pinch-1 was up-regulated in leukemia BMSC and its possible effect.Clin Exp Med. 2013 Feb;13(1):21-7. doi: 10.1007/s10238-012-0176-7. Epub 2012 Feb 5.
922 The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.J Exp Med. 2013 Jan 14;210(1):15-22. doi: 10.1084/jem.20120596. Epub 2012 Dec 31.
923 Clinical significance of LMO1 in gastric cancer tissue and its association with apoptosis of cancer cells.Oncol Lett. 2017 Dec;14(6):6511-6518. doi: 10.3892/ol.2017.7102. Epub 2017 Sep 28.
924 ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9.Genes Chromosomes Cancer. 2016 Mar;55(3):242-50. doi: 10.1002/gcc.22327. Epub 2015 Nov 6.
925 Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas.Mol Med Rep. 2012 Feb;5(2):509-12. doi: 10.3892/mmr.2011.681. Epub 2011 Nov 16.
926 The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.Haematologica. 2012 Sep;97(9):1405-13. doi: 10.3324/haematol.2011.059030. Epub 2012 Apr 4.
927 Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.PLoS One. 2012;7(9):e44979. doi: 10.1371/journal.pone.0044979. Epub 2012 Sep 27.
928 MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily.Gene. 2001 Apr 18;267(2):173-82. doi: 10.1016/s0378-1119(01)00406-1.
929 The molecular basis of leukemia.Hematology Am Soc Hematol Educ Program. 2004:80-97. doi: 10.1182/asheducation-2004.1.80.
930 The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line.Haematologica. 2006 Jun;91(6):765-71.
931 Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug-resistant leukaemia cell sublines.Br J Cancer. 1998 Jun;77(12):2076-80. doi: 10.1038/bjc.1998.350.
932 Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis.Clin Cancer Res. 2004 Dec 15;10(24):8386-95. doi: 10.1158/1078-0432.CCR-04-1029.
933 Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.PLoS One. 2010 Sep 2;5(9):e12520. doi: 10.1371/journal.pone.0012520.
934 Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.EBioMedicine. 2016 Jun;8:173-183. doi: 10.1016/j.ebiom.2016.04.038. Epub 2016 May 13.
935 Meis2 as a critical player in MN1-induced leukemia.Blood Cancer J. 2017 Sep 29;7(9):e613. doi: 10.1038/bcj.2017.86.
936 Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ.Nucleic Acids Res. 2003 Jun 1;31(11):2735-44. doi: 10.1093/nar/gkg401.
937 Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.Cell Death Dis. 2013 Dec 5;4(12):e941. doi: 10.1038/cddis.2013.469.
938 NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.PLoS Genet. 2019 Nov 1;15(11):e1008463. doi: 10.1371/journal.pgen.1008463. eCollection 2019 Nov.
939 De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.Nat Commun. 2018 May 2;9(1):1770. doi: 10.1038/s41467-018-04180-1.
940 ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.Oncotarget. 2016 Jun 21;7(25):38347-38358. doi: 10.18632/oncotarget.9520.
941 A MENage Trois in leukemia.Cancer Cell. 2008 Jul 8;14(1):3-5. doi: 10.1016/j.ccr.2008.06.009.
942 Nuclear Repositioning of the Non-Translocated HLXB9 Allele in the Leukaemia Cell Line GDM-1 Harbouring a t(6;7)(q23;q36).Cytogenet Genome Res. 2017;153(1):10-17. doi: 10.1159/000480745. Epub 2017 Sep 29.
943 Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.J Biol Chem. 2010 May 7;285(19):14346-55. doi: 10.1074/jbc.M110.109314. Epub 2010 Mar 9.
944 Regulation of DNA methylation and tumor suppression gene expression by miR-29b in leukemia patients and related mechanisms.Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):158-165. doi: 10.26355/eurrev_201801_14113.
945 Ecotropic viral integration site 1 regulates the progression of acute myeloid leukemia via MS4A3-mediated TGF/EMT signaling pathway.Oncol Lett. 2018 Aug;16(2):2701-2708. doi: 10.3892/ol.2018.8890. Epub 2018 Jun 4.
946 Epigenetic analysis of childhood acute lymphoblastic leukemia.Epigenetics. 2009 Apr 1;4(3):185-93. doi: 10.4161/epi.4.3.8752. Epub 2009 Apr 12.
947 Refined solution structure and backbone dynamics of 15N-labeled C12A-p8MTCP1 studied by NMR relaxation.J Biomol NMR. 1999 Dec;15(4):271-88. doi: 10.1023/a:1008336418418.
948 Predictive value of multidrug resistance proteins and cellular drug resistance in childhood relapsed acute lymphoblastic leukemia.J Cancer Res Clin Oncol. 2007 Nov;133(11):875-93. doi: 10.1007/s00432-007-0274-1. Epub 2007 Aug 2.
949 Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells.AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1629-32. doi: 10.1089/08892220050193065.
950 NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells.Leuk Res. 2002 Sep;26(9):857-62. doi: 10.1016/s0145-2126(02)00016-4.
951 Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells.Nucleic Acids Res. 2010 Sep;38(16):5384-95. doi: 10.1093/nar/gkq307. Epub 2010 Apr 28.
952 Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia.BMC Cancer. 2013 Oct 5;13:457. doi: 10.1186/1471-2407-13-457.
953 Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.Int J Hematol. 2014 Jan;99(1):21-31. doi: 10.1007/s12185-013-1466-x. Epub 2013 Nov 21.
954 Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.Blood. 2013 May 2;121(18):3714-7. doi: 10.1182/blood-2012-11-465641. Epub 2013 Feb 20.
955 The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A.Biochem Biophys Res Commun. 1999 Nov 2;264(3):871-7. doi: 10.1006/bbrc.1999.1605.
956 Deficient expression of NCR in NK cells from acute myeloid leukemia: Evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction.Blood. 2007 Jan 1;109(1):323-30. doi: 10.1182/blood-2005-08-027979. Epub 2006 Aug 29.
957 Regulation of the human leukaemia inhibitory factor (LIF) promoter in HEC-1B endometrial adenocarcinoma cells.Mol Hum Reprod. 1997 Sep;3(9):789-93. doi: 10.1093/molehr/3.9.789.
958 Chromosome band 16q22-linked familial AML: exclusion of candidate genes, and possible disease risk modification by NQO1 polymorphisms.Genes Chromosomes Cancer. 2004 Nov;41(3):278-82. doi: 10.1002/gcc.20084.
959 Selective activation of NFAT by promyelocytic leukemia protein.Oncogene. 2008 Jun 19;27(27):3821-30. doi: 10.1038/onc.2008.2. Epub 2008 Feb 4.
960 Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations.Blood. 2019 Apr 18;133(16):1766-1777. doi: 10.1182/blood-2018-09-875047. Epub 2019 Feb 12.
961 Disruption of TCBA1 associated with a de novo t(1;6)(q32.2;q22.3) presenting in a child with developmental delay and recurrent infections.J Med Genet. 2006 Feb;43(2):143-7. doi: 10.1136/jmg.2004.029660. Epub 2005 May 20.
962 Expression of cell surface NM23 proteins of human leukemia cell lines of various cellular lineage and differentiation stages.Leuk Res. 2002 Jun;26(6):569-76. doi: 10.1016/s0145-2126(01)00171-0.
963 Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene.Cancer Genet Cytogenet. 2006 Aug;169(1):1-11. doi: 10.1016/j.cancergencyto.2005.09.008.
964 NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes.J Immunol. 2003 Jul 1;171(1):299-306. doi: 10.4049/jimmunol.171.1.299.
965 Superoxide-Generating Nox5 Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype.J Virol. 2015 Sep;89(17):9080-9. doi: 10.1128/JVI.00983-15. Epub 2015 Jun 24.
966 NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling.Oncogene. 2020 Jan;39(5):975-986. doi: 10.1038/s41388-019-1042-9. Epub 2019 Oct 4.
967 Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.Mol Cell Biol. 2008 Mar;28(6):2023-34. doi: 10.1128/MCB.02130-07. Epub 2008 Jan 2.
968 Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha.Oncogene. 2004 Jan 22;23(3):665-78. doi: 10.1038/sj.onc.1207073.
969 Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.Mol Cancer. 2010 Aug 27;9:226. doi: 10.1186/1476-4598-9-226.
970 The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia.Exp Hematol. 2017 Nov;55:76-85.e3. doi: 10.1016/j.exphem.2017.07.009. Epub 2017 Jul 28.
971 Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia.Oncogene. 2014 Apr 24;33(17):2169-78. doi: 10.1038/onc.2013.169. Epub 2013 Jun 3.
972 Mapping of leukaemia-associated breakpoints in chromosome band 3q21 using a newly established PAC contig.Br J Haematol. 2000 Aug;110(2):343-50. doi: 10.1046/j.1365-2141.2000.02192.x.
973 Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia.Int J Cancer. 2006 Apr 15;118(8):1945-53. doi: 10.1002/ijc.21584.
974 PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Hum Mol Genet. 2012 Nov 1;21(21):4793-804.
975 The functional polymorphisms of LIS1 are associated with acute myeloid leukemia risk in a Han Chinese population.Leuk Res. 2017 Mar;54:7-11. doi: 10.1016/j.leukres.2016.12.007. Epub 2017 Jan 2.
976 Fluctuation of gene expression for poly(ADP-ribose) synthetase during hemin-induced erythroid differentiation of human leukemia K562 cells and its reversion process.Biochim Biophys Acta. 1991 Mar 26;1088(3):359-64. doi: 10.1016/0167-4781(91)90125-6.
977 PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia.Int J Cancer. 2017 Jul 15;141(2):324-335. doi: 10.1002/ijc.30739. Epub 2017 May 8.
978 Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance.Genes Chromosomes Cancer. 2011 Dec;50(12):1043-53. doi: 10.1002/gcc.20922. Epub 2011 Aug 24.
979 The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.Mol Cell Biol. 2003 Jan;23(1):119-30. doi: 10.1128/MCB.23.1.119-130.2003.
980 Synergistic antitumoral efficacy of a novel replicative adenovirus SG611-PDCD5 and daunorubicin in human leukemic cells.Onco Targets Ther. 2018 Aug 23;11:5121-5132. doi: 10.2147/OTT.S167868. eCollection 2018.
981 LIM-domain-only proteins in cancer.Nat Rev Cancer. 2013 Feb;13(2):111-22. doi: 10.1038/nrc3418. Epub 2013 Jan 10.
982 The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia.Acta Biochim Pol. 2002;49(1):99-107.
983 The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies.Oncotarget. 2017 Jul 1;8(39):65445-65456. doi: 10.18632/oncotarget.18920. eCollection 2017 Sep 12.
984 Lack of the Polycomb-group gene rae28 causes maturation arrest at the early B-cell developmental stage.Exp Hematol. 2001 Jan;29(1):93-103. doi: 10.1016/s0301-472x(00)00620-2.
985 PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.Blood. 2019 Apr 18;133(16):1729-1741. doi: 10.1182/blood-2018-07-860726. Epub 2019 Feb 12.
986 Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity.Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3837-42. doi: 10.1073/pnas.0712250105. Epub 2008 Mar 3.
987 The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.Cancer Res. 2012 May 1;72(9):2275-84. doi: 10.1158/0008-5472.CAN-11-3159. Epub 2012 Mar 9.
988 Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid Cancers.Front Genet. 2019 Jan 15;9:721. doi: 10.3389/fgene.2018.00721. eCollection 2018.
989 Protein kinase D2: a versatile player in cancer biology.Oncogene. 2018 Mar;37(10):1263-1278. doi: 10.1038/s41388-017-0052-8. Epub 2017 Dec 20.
990 PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation.Br J Haematol. 2008 Feb;140(3):344-7. doi: 10.1111/j.1365-2141.2007.06920.x. Epub 2007 Dec 5.
991 The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.Apoptosis. 2014 Jan;19(1):201-9. doi: 10.1007/s10495-013-0910-y.
992 Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors.Mol Carcinog. 2001 Sep;32(1):44-53. doi: 10.1002/mc.1063.
993 Human CAP10-Like Protein 46kDa Gene Promotes Malignancy in Colorectal Cancer.OMICS. 2017 May;21(5):266-274. doi: 10.1089/omi.2017.0037.
994 The N-terminus of murine leukaemia virus p12 protein is required for mature core stability.PLoS Pathog. 2014 Oct 30;10(10):e1004474. doi: 10.1371/journal.ppat.1004474. eCollection 2014 Oct.
995 POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.Leukemia. 2010 May;24(5):950-7. doi: 10.1038/leu.2010.61. Epub 2010 Apr 8.
996 Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells.Proc Natl Acad Sci U S A. 1987 May;84(9):2868-71. doi: 10.1073/pnas.84.9.2868.
997 siRNA-mediated down-regulation of iASPP promotes apoptosis induced by etoposide and daunorubicin in leukemia cells expressing wild-type p53. Leuk Res. 2009 Sep;33(9):1243-8. doi: 10.1016/j.leukres.2009.02.016. Epub 2009 Mar 18.
998 Expression and distribution of PPP2R5C gene in leukemia.J Hematol Oncol. 2011 May 6;4:21. doi: 10.1186/1756-8722-4-21.
999 The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10.Genomics. 1996 Oct 1;37(1):24-8. doi: 10.1006/geno.1996.0516.
1000 PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.J Clin Invest. 2018 Aug 1;128(8):3250-3264. doi: 10.1172/JCI99862. Epub 2018 Jul 23.
1001 Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia.Tohoku J Exp Med. 2002 Mar;196(3):193-201. doi: 10.1620/tjem.196.193.
1002 Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor.Oncogene. 2008 Oct 9;27(46):6056-67. doi: 10.1038/onc.2008.210. Epub 2008 Jul 7.
1003 Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia.J Vis Exp. 2019 Sep 5;(151):10.3791/59593. doi: 10.3791/59593.
1004 AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.Blood. 2011 Dec 1;118(23):6132-40. doi: 10.1182/blood-2011-01-323147. Epub 2011 Oct 14.
1005 Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.Dev Biol. 2017 Jan 1;421(1):16-26. doi: 10.1016/j.ydbio.2016.11.003. Epub 2016 Nov 10.
1006 GATA4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating BCL2 and MDM2.Mol Med Rep. 2017 Nov;16(5):6290-6298. doi: 10.3892/mmr.2017.7369. Epub 2017 Aug 28.
1007 From oncogene to tumor suppressor: the dual role of Myc in leukemia.Cell Cycle. 2012 May 1;11(9):1757-64. doi: 10.4161/cc.19883. Epub 2012 May 1.
1008 Mechanisms involved in the induced differentiation of leukemia cells.Pharmacol Ther. 2003 Dec;100(3):257-90. doi: 10.1016/j.pharmthera.2003.09.002.
1009 Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells.Cell Signal. 2014 Oct;26(10):2202-9. doi: 10.1016/j.cellsig.2014.05.015. Epub 2014 May 29.
1010 Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.Cell Rep. 2018 Jun 12;23(11):3127-3136. doi: 10.1016/j.celrep.2018.05.034.
1011 In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity.Leukemia. 2014 Jun;28(6):1316-25. doi: 10.1038/leu.2013.374. Epub 2013 Nov 13.
1012 Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma. PLoS One. 2013 Nov 6;8(11):e79863. doi: 10.1371/journal.pone.0079863. eCollection 2013.
1013 Rap1GAP alters leukemia cell differentiation, apoptosis and invasion invitro.Oncol Rep. 2012 Aug;28(2):622-8. doi: 10.3892/or.2012.1825. Epub 2012 May 18.
1014 The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells.Acta Pharmacol Sin. 2011 Jan;32(1):99-107. doi: 10.1038/aps.2010.185. Epub 2010 Dec 13.
1015 The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.Mol Cancer. 2009 Jul 1;8:42. doi: 10.1186/1476-4598-8-42.
1016 Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.J Biol Chem. 2008 Sep 26;283(39):26820-8. doi: 10.1074/jbc.M802315200. Epub 2008 Jul 30.
1017 A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.Blood. 2007 Jul 1;110(1):323-33. doi: 10.1182/blood-2006-10-052282. Epub 2007 Mar 14.
1018 Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma.Br J Haematol. 2008 Apr;141(2):212-5. doi: 10.1111/j.1365-2141.2007.06956.x.
1019 RALBP1/RLIP76 mediates multidrug resistance.Int J Oncol. 2007 Jan;30(1):139-44.
1020 Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA.Biochim Biophys Acta. 1996 Jun 11;1281(2):164-72. doi: 10.1016/0005-2736(96)00005-3.
1021 Genomic c-Myc quadruplex DNA selectively kills leukemia.Mol Cancer Ther. 2012 Jan;11(1):66-76. doi: 10.1158/1535-7163.MCT-11-0515. Epub 2011 Nov 14.
1022 Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning.Int J Oncol. 2012 Jan;40(1):93-8. doi: 10.3892/ijo.2011.1173. Epub 2011 Aug 19.
1023 Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.Immunity. 1997 Jun;6(6):773-82. doi: 10.1016/s1074-7613(00)80452-5.
1024 Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3901-6. doi: 10.1073/pnas.1301045110. Epub 2013 Feb 14.
1025 Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1.Genes Chromosomes Cancer. 2003 Mar;36(3):313-6. doi: 10.1002/gcc.10176.
1026 Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts.Leukemia. 2012 May;26(5):927-33. doi: 10.1038/leu.2011.322. Epub 2011 Nov 18.
1027 Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies.Ann Oncol. 2019 Apr 1;30(4):528-541. doi: 10.1093/annonc/mdz045.
1028 The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.Leukemia. 2013 Jul;27(7):1461-8. doi: 10.1038/leu.2013.42. Epub 2013 Feb 13.
1029 Persistent detection of a novel MLL-SACM1L rearrangement in the absence of leukemia.Leuk Res. 2010 Oct;34(10):1398-401. doi: 10.1016/j.leukres.2010.05.001.
1030 The Study of SALL4 Gene and BMI-1 Gene Expression in Acute Myeloid Leukemia Patients.Lab Med. 2020 May 6;51(3):265-270. doi: 10.1093/labmed/lmz056.
1031 Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4.
1032 Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice.AIDS. 2000 Dec 22;14(18):2813-22. doi: 10.1097/00002030-200012220-00002.
1033 High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome.Genes Chromosomes Cancer. 2012 Feb;51(2):196-206. doi: 10.1002/gcc.20944. Epub 2011 Nov 10.
1034 Blocking the proliferation of human tumor cell lines by peptidase inhibitors from Bauhinia seeds.Planta Med. 2013 Mar;79(3-4):227-35. doi: 10.1055/s-0032-1328156. Epub 2013 Jan 23.
1035 Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.FEBS J. 2010 Apr;277(8):1832-42. doi: 10.1111/j.1742-4658.2010.07609.x. Epub 2010 Mar 4.
1036 Novel mutations in ataxia telangiectasia and AOA2 associated with prolonged survival.J Neurol Sci. 2013 Dec 15;335(1-2):134-8. doi: 10.1016/j.jns.2013.09.014. Epub 2013 Sep 17.
1037 Methylation of SFRP5 is related to multidrug resistance in leukemia cells.Cancer Gene Ther. 2014 Feb;21(2):83-9. doi: 10.1038/cgt.2013.87. Epub 2014 Jan 17.
1038 Analysis of SH2D1A mutations in patients with severe Epstein-Barr virus infections, Burkitt's lymphoma, and Hodgkin's lymphoma.Ann Hematol. 2002 Aug;81(8):441-7. doi: 10.1007/s00277-002-0490-3. Epub 2002 Jul 20.
1039 PCR testing for HCV in anti-HCV negative blood donors involved in the so called HCV +ve post-transfusion hepatitis.Transfus Sci. 2000 Jun;22(3):161-4. doi: 10.1016/s0955-3886(00)00043-6.
1040 The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.J Biol Chem. 2004 Feb 13;279(7):5374-9. doi: 10.1074/jbc.M306407200. Epub 2003 Nov 25.
1041 The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.J Immunol. 2004 Dec 1;173(11):6841-9. doi: 10.4049/jimmunol.173.11.6841.
1042 Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.Haematologica. 2008 Nov;93(11):1728-33. doi: 10.3324/haematol.13044. Epub 2008 Sep 11.
1043 Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia.Blood. 2000 Jun 15;95(12):3945-50.
1044 Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5.PLoS One. 2014 Feb 3;9(2):e87448. doi: 10.1371/journal.pone.0087448. eCollection 2014.
1045 Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes. Nat Genet. 2017 May;49(5):742-752. doi: 10.1038/ng.3833. Epub 2017 Apr 3.
1046 Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.Leuk Lymphoma. 2018 Oct;59(10):2423-2430. doi: 10.1080/10428194.2017.1387906. Epub 2017 Oct 18.
1047 Epigenetic regulator Smchd1 functions as a tumor suppressor.Cancer Res. 2013 Mar 1;73(5):1591-9. doi: 10.1158/0008-5472.CAN-12-3019. Epub 2012 Dec 26.
1048 Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.Blood. 2008 May 1;111(9):4716-22. doi: 10.1182/blood-2007-10-113068. Epub 2008 Feb 25.
1049 PML a target of translocations in APL is a regulator of cellular senescence.Leukemia. 2002 Oct;16(10):1918-26. doi: 10.1038/sj.leu.2402722.
1050 Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II.J Biol Chem. 1999 Jul 30;274(31):21981-5. doi: 10.1074/jbc.274.31.21981.
1051 Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia.Cell Res. 2018 Feb;28(2):172-186. doi: 10.1038/cr.2017.146. Epub 2017 Nov 17.
1052 SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias.Cancer Res. 2015 Jun 1;75(11):2387-99. doi: 10.1158/0008-5472.CAN-14-3625. Epub 2015 Apr 9.
1053 Epigenetic silencing of SOCS5 potentiates JAK-STAT signaling and progression of T-cell acute lymphoblastic leukemia.Cancer Sci. 2019 Jun;110(6):1931-1946. doi: 10.1111/cas.14021. Epub 2019 May 3.
1054 SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.Mol Cell. 2016 Mar 17;61(6):859-73. doi: 10.1016/j.molcel.2016.02.024.
1055 Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms.Mod Pathol. 2010 Jan;23(1):105-12. doi: 10.1038/modpathol.2009.140. Epub 2009 Oct 2.
1056 SOX12: a novel potential target for acute myeloid leukaemia.Br J Haematol. 2017 Feb;176(3):421-430. doi: 10.1111/bjh.14425. Epub 2016 Nov 18.
1057 SOX6 blocks the proliferation of BCR-ABL1(+) and JAK2V617F(+) leukemic cells.Sci Rep. 2019 Mar 4;9(1):3388. doi: 10.1038/s41598-019-39926-4.
1058 Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.Blood. 2015 Jun 18;125(25):3928-36. doi: 10.1182/blood-2014-06-580993. Epub 2015 May 4.
1059 Identification of SPAG9 as a novel JAK2 fusion partner gene in pediatric acute lymphoblastic leukemia with t(9;17)(p24;q21).Genes Chromosomes Cancer. 2015 Jul;54(7):401-8. doi: 10.1002/gcc.22251. Epub 2015 May 7.
1060 Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region.Leukemia. 2007 Oct;21(10):2137-44. doi: 10.1038/sj.leu.2404879. Epub 2007 Aug 9.
1061 The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia.Oncotarget. 2017 Jun 6;8(23):37104-37114. doi: 10.18632/oncotarget.16183.
1062 ETV6-RUNX1 interacts with a region in SPIB intron 1 to regulate gene expression in pre-B-cell acute lymphoblastic leukemia.Exp Hematol. 2019 May;73:50-63.e2. doi: 10.1016/j.exphem.2019.03.004. Epub 2019 Apr 12.
1063 Sorcin, an important gene associated with multidrug-resistance in human leukemia cells.Leuk Res. 2006 Apr;30(4):469-76. doi: 10.1016/j.leukres.2005.08.024. Epub 2005 Oct 6.
1064 Expression of SSX genes in human tumors.Int J Cancer. 1998 Jul 3;77(1):19-23. doi: 10.1002/(sici)1097-0215(19980703)77:1<19::aid-ijc4>3.0.co;2-2.
1065 STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.Cell Rep. 2018 Sep 11;24(11):3045-3060.e5. doi: 10.1016/j.celrep.2018.08.030.
1066 SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin.Mol Cell Biol. 2005 Jun;25(12):5095-105. doi: 10.1128/MCB.25.12.5095-5105.2005.
1067 The Oncogenic Potential of SUV39H2: A Comprehensive and Perspective View.J Cancer. 2019 Jan 1;10(3):721-729. doi: 10.7150/jca.28254. eCollection 2019.
1068 N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia.J Biol Chem. 2006 Sep 22;281(38):28122-30. doi: 10.1074/jbc.M512391200. Epub 2006 May 12.
1069 Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload.Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19635-19645. doi: 10.1073/pnas.1908998116. Epub 2019 Sep 5.
1070 Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia.Haematologica. 2016 Aug;101(8):951-8. doi: 10.3324/haematol.2016.143875. Epub 2016 May 5.
1071 Expression of transcobalamin II receptors by human leukemia K562 and HL-60 cells.Blood. 1990 Oct 1;76(7):1380-6.
1072 The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.Blood. 1996 Jun 1;87(11):4607-17.
1073 Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo.Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):806-13.
1074 A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD+ AML.Blood. 2014 Apr 17;123(16):2530-9. doi: 10.1182/blood-2013-07-512194. Epub 2014 Mar 7.
1075 Identification and characterization of a soluble suppressor factor(s) in the serum of AKR mice bearing lymphocytic leukemia.Cell Immunol. 1983 Nov;82(1):163-73. doi: 10.1016/0008-8749(83)90150-8.
1076 Promoter analysis of TFPT (FB1), a molecular partner of TCF3 (E2A) in childhood acute lymphoblastic leukemia.Biochem Biophys Res Commun. 2001 Nov 16;288(5):1250-7. doi: 10.1006/bbrc.2001.5906.
1077 Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells.Blood. 2001 Nov 1;98(9):2714-9. doi: 10.1182/blood.v98.9.2714.
1078 Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias.Chin Med J (Engl). 2014;127(9):1645-50.
1079 A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.Leukemia. 2013 Apr;27(4):932-40. doi: 10.1038/leu.2012.283. Epub 2012 Oct 3.
1080 Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.J Exp Med. 1996 May 1;183(5):2283-91. doi: 10.1084/jem.183.5.2283.
1081 TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia.J Hematol Oncol. 2016 Nov 25;9(1):128. doi: 10.1186/s13045-016-0360-4.
1082 Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents.Molecules. 2019 Apr 18;24(8):1529. doi: 10.3390/molecules24081529.
1083 Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.Int J Cancer. 2004 May 1;109(5):786-92. doi: 10.1002/ijc.20041.
1084 The promyelocytic leukemia protein represses A20-mediated transcription.J Biol Chem. 2002 Aug 30;277(35):31734-9. doi: 10.1074/jbc.M201648200. Epub 2002 Jun 21.
1085 Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia.Blood. 2010 May 20;115(20):4061-70. doi: 10.1182/blood-2008-06-163386. Epub 2010 Mar 11.
1086 TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).Oncogene. 1991 Oct;6(10):1887-93.
1087 TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice.Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16600-5. doi: 10.1073/pnas.0407541101. Epub 2004 Nov 15.
1088 Somatic mutation of TRAF3 gene is rare in common human cancers and acute leukemias.Acta Oncol. 2008;47(8):1615-7. doi: 10.1080/02841860802195277.
1089 TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.J Cell Sci. 2011 Oct 15;124(Pt 20):3492-502. doi: 10.1242/jcs.088799. Epub 2011 Oct 7.
1090 HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.J Biol Chem. 2004 Feb 27;279(9):8181-9. doi: 10.1074/jbc.M306751200. Epub 2003 Dec 8.
1091 Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6200-5. doi: 10.1073/pnas.0609174104. Epub 2007 Mar 30.
1092 Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.Clin Lymphoma Myeloma Leuk. 2015 Feb;15(2):115-127.e15. doi: 10.1016/j.clml.2014.07.011. Epub 2014 Aug 12.
1093 Quantitative analysis and modeling of glucocorticoid-controlled gene expression.Pharmacogenomics. 2010 Nov;11(11):1545-60. doi: 10.2217/pgs.10.125.
1094 Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL).Leuk Res. 2006 Jul;30(7):883-9. doi: 10.1016/j.leukres.2005.11.012. Epub 2006 Jan 6.
1095 Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.Cell Stem Cell. 2015 Aug 6;17(2):152-164. doi: 10.1016/j.stem.2015.06.006. Epub 2015 Jul 23.
1096 Single nucleotide polymorphism of the JWA gene is associated with risk of leukemia: a case-control study in a Chinese population.J Toxicol Environ Health A. 2007 Jun;70(11):895-900. doi: 10.1080/15287390701285956.
1097 Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.PLoS One. 2010 Jul 2;5(7):e11418. doi: 10.1371/journal.pone.0011418.
1098 Acute myeloid leukemia with t(7;21)(q11.2;q22) expresses a novel, reversed-sequence RUNX1-DTX2 chimera.Int J Hematol. 2012 Aug;96(2):268-73. doi: 10.1007/s12185-012-1112-z. Epub 2012 Jun 4.
1099 FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.Leuk Res. 2012 Nov;36(11):1339-46. doi: 10.1016/j.leukres.2012.06.011. Epub 2012 Aug 16.
1100 Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia due to the homozygous p.Pro221Ser FLVCR1 mutation.Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):732-739. doi: 10.1002/ajmg.b.32570. Epub 2017 Aug 2.
1101 The small leucine rich proteoglycan fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue.Cancer Biomark. 2016;16(1):191-202. doi: 10.3233/CBM-150555.
1102 GPX3 methylation in bone marrow predicts adverse prognosis and leukemia transformation in myelodysplastic syndrome.Cancer Med. 2017 Jan;6(1):267-274. doi: 10.1002/cam4.984. Epub 2016 Nov 28.
1103 KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.Leuk Lymphoma. 2018 Jan;59(1):204-213. doi: 10.1080/10428194.2017.1324156. Epub 2017 May 25.
1104 Design, synthesis and evaluation of novel sulfonamides as potential anticancer agents.Comput Biol Chem. 2018 Jun;74:294-303. doi: 10.1016/j.compbiolchem.2018.04.006. Epub 2018 Apr 10.
1105 Leukemia-related protein 16 (LRP16) promotes tumor growth and metastasis in pancreatic cancer.Onco Targets Ther. 2018 Mar 5;11:1215-1222. doi: 10.2147/OTT.S157914. eCollection 2018.
1106 The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
1107 Relation of "lymphoid" phenotype and response to chemotherapy incorporating vincristine-prednisolone in the acute phase of Ph1 positive leukemia.Cancer. 1979 Feb;43(2):426-34. doi: 10.1002/1097-0142(197902)43:2<426::aid-cncr2820430204>3.0.co;2-h.
1108 Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and Other Chromosome Abnormalities.Cytogenet Genome Res. 2016;149(3):165-170. doi: 10.1159/000448447. Epub 2016 Sep 9.
1109 Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.Mol Cancer Ther. 2017 Jul;16(7):1401-1411. doi: 10.1158/1535-7163.MCT-17-0099. Epub 2017 Apr 26.
1110 Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies.Cancer Res. 2008 Jun 1;68(11):4116-22. doi: 10.1158/0008-5472.CAN-08-0085.
1111 TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3.