Details of Disease

General Information of Disease (ID: DIS0D2NT)

Disease Name	Opioid-induced constipation
Synonyms	OIC
Disease Class	DB32: Large intestine motility disorder
Definition	A constipation disorder caused by use of opiods. OIC may present immediately when a patient takes the opioid, or it may present gradually during opioid therapy.
Disease Hierarchy	DISRQXWI: Constipation DIS0D2NT: Opioid-induced constipation
ICD Code	ICD-11 ICD-11: DB32.1 ICD-10 ICD-10: K59.0 ICD-9 ICD-9: 564 Expand ICD-9 564
Disease Identifiers	MONDO ID MONDO_0100187 MESH ID D000079689 UMLS CUI C3160897 MedGen ID 1641995

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Methylnaltrexone bromide	DMZTGN2	Approved	Small molecular drug	[1]
Naldemedine Tosylate	DMGD3YH	Approved	Small molecular drug	[2]
Naloxegol	DML0B41	Approved	Small molecular drug	[3]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TD-1211	DMTJMK5	Phase 2	Small molecular drug	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CLCN2	TT30NW6	Limited	Biomarker	[5]
OPRM1	TTKWM86	Strong	Biomarker	[6]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
LGALS14	OTOR23GX	Limited	Biomarker	[5]
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References

1	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7539).
4	ClinicalTrials.gov (NCT01401985) A Study of TD-1211 in Subjects With Opioid-Induced Constipation (OIC). U.S. National Institutes of Health.
5	Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders.Dig Dis Sci. 2017 Dec;62(12):3568-3578. doi: 10.1007/s10620-017-4680-1. Epub 2017 Aug 28.
6	Pharmacologic effects of naldemedine, a peripherally acting -opioid receptor antagonist, in in vitro and in vivo models of opioid-induced constipation.Neurogastroenterol Motil. 2019 May;31(5):e13563. doi: 10.1111/nmo.13563. Epub 2019 Feb 28.