Details of Disease

General Information of Disease (ID: DIS0HU8N)

• Disease Name: Urinary tract disease
• Synonyms: urological disorders; urological disorder; urological diseases; urological disease; urologic disorder; urologic disease; urinary tract disorder; urinary tract diseases; urinary tract disease; urinary system disorder; urinary system disease; urinary disease; renal system disease or disorder; renal system disease; non-neoplastic urinary tract disease; disorder of urinary system; disorder of the urinary system; disorder of renal system; diseases, urological; diseases, urologic; diseases, urinary tract; disease, urological; disease, urologic; disease, urinary tract; disease or disorder of renal system; disease of renal system
• Disease Class: GC2Z: Urinary system disease
• Definition: A disease involving the renal system.
• Disease Hierarchy:
  DISH7H5I: Human disease
  DIS0HU8N: Urinary tract disease
• ICD Code:
  ICD-11: ICD-11: GC2Z
  Expand ICD-11: 'GC2Z
• Disease Identifiers:
  MONDO ID: MONDO_0002118
  MESH ID: D014570
  UMLS CUI: C0042075
  MedGen ID: 21791
  SNOMED CT ID: 128606002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Diatrizoate	DMWAG4J	Approved	Small molecular drug	[1]
Iopentol	DMHKDO8	Approved	Small molecular drug	[1]
Mitomycin	DMH0ZJE	Approved	Small molecular drug	[2]
Phloroglucinol	DMUKMC8	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
XEL-005OP	DMX4LQM	Investigative	NA	[3]
ZAMI-633	DMLJMBW	Investigative	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
RDH14	DEWDJU4	Strong	Altered Expression	[4]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NLRP4	OT864X7M	Strong	Altered Expression	[4]
PAN2	OTB65N2I	Strong	Altered Expression	[4]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Mitomycin FDA Label
• [3] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [4] Evaluation of urinary CA19-9 levels in bladder cancer patients classified according to the combinations of Lewis and Secretor blood group genotypes.Int J Urol. 2007 Sep;14(9):795-9. doi: 10.1111/j.1442-2042.2007.01840.x.