Details of Disease | DrugMAP

General Information of Disease (ID: DIS1ILLO)

Disease Name	Alzheimer disease type 1
Synonyms	Alzheimer disease, protection against; Alzheimer disease, early-onset, with cerebral amyloid angiopathy; AD; Alzheimer disease, late-onset, susceptibility to; presenile and senile dementia; Alzheimer disease, familial, 1; Alzheimer disease 1; Alzheimer disease, susceptibility to; AD1; Alzheimer disease; early-onset familial form of Alzheimer disease; Alzheimer disease 1, familial
Disease Hierarchy	DISFAUJO: Early-onset autosomal dominant Alzheimer disease DIS1ILLO: Alzheimer disease type 1
Disease Identifiers	MONDO ID MONDO_0007088 MESH ID C536594 UMLS CUI C1863052 OMIM ID 104300 MedGen ID 354892

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APP	TTE4KHA	Strong	Autosomal dominant	[1]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
A2M	OTFTX90K	No Known	Unknown	[1]
APP	OTKFD7R4	Strong	Autosomal dominant	[1]
PTS	OTTYWQXR	Strong	Biomarker	[2]
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References

1	The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
2	Chromosome-wide assessment of replication timing for human chromosomes 11q and 21q: disease-related genes in timing-switch regions.Hum Mol Genet. 2002 Jan 1;11(1):13-21. doi: 10.1093/hmg/11.1.13.