| 1 |
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.Ann Med. 2008;40(3):232-9. doi: 10.1080/07853890701842988.
|
| 2 |
Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock.Br J Exp Pathol. 1986 Jun;67(3):313-9.
|
| 3 |
Repeat oral dose toxicity studies of melamine in rats and monkeys.Arch Toxicol. 2013 Mar;87(3):517-27. doi: 10.1007/s00204-012-0939-7. Epub 2012 Sep 28.
|
| 4 |
Changes Due to Ageing in the Glycan Structure of Alpha-2-Macroglobulin and Its Reactivity with Ligands.Protein J. 2019 Feb;38(1):23-29. doi: 10.1007/s10930-018-9806-6.
|
| 5 |
Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.Haematologica. 2018 Jul;103(7):1136-1142. doi: 10.3324/haematol.2018.187815. Epub 2018 Mar 15.
|
| 6 |
Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease.J Transl Med. 2018 Apr 17;16(1):104. doi: 10.1186/s12967-018-1476-9.
|
| 7 |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Carcinogenesis. 2004 Aug;25(8):1495-505. doi: 10.1093/carcin/bgh155. Epub 2004 Apr 1.
|
| 8 |
Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients.Neurosci Lett. 2000 Nov 17;294(2):69-72. doi: 10.1016/s0304-3940(00)01518-4.
|
| 9 |
Pharmacogenetic Study on the Impact of Rivastigmine Concerning Genetic Variants of A2M and IL-6 Genes on Iranian Alzheimer's Patients.Mol Neurobiol. 2016 Sep;53(7):4521-8. doi: 10.1007/s12035-015-9387-8. Epub 2015 Aug 21.
|
| 10 |
Hepatitis B virus X antigen promotes transforming growth factor-beta1 (TGF-beta1) activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin.J Gen Virol. 2004 Feb;85(Pt 2):275-282. doi: 10.1099/vir.0.19650-0.
|
| 11 |
Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study.J Proteomics. 2019 Feb 10;192:280-290. doi: 10.1016/j.jprot.2018.09.009. Epub 2018 Sep 24.
|
| 12 |
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.Am J Pathol. 2004 Nov;165(5):1479-88. doi: 10.1016/s0002-9440(10)63406-2.
|
| 13 |
Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.Toxicol Sci. 2016 Jan;149(1):67-88. doi: 10.1093/toxsci/kfv214. Epub 2015 Sep 22.
|
| 14 |
A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice.Proteomics. 2009 Feb;9(4):1044-56. doi: 10.1002/pmic.200701135.
|
| 15 |
Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms.Kidney Int. 1998 Jan;53(1):67-75. doi: 10.1046/j.1523-1755.1998.00734.x.
|
| 16 |
In situ hybridization studies of alpha 2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma.Prostate. 1996 May;28(5):311-7. doi: 10.1002/(SICI)1097-0045(199605)28:5<311::AID-PROS7>3.0.CO;2-E.
|
| 17 |
Plasma proteinase inhibitor activity and hemostasis tests in children with nephrotic syndrome. Effect of prednisone alone and prednisone plus epsilon-aminocaproic acid treatment regimens: a preliminary report. Am J Ther. 2001 Mar-Apr;8(2):97-107. doi: 10.1097/00045391-200103000-00004.
|
| 18 |
Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis.Clin Gastroenterol Hepatol. 2019 Aug;17(9):1867-1876.e3. doi: 10.1016/j.cgh.2018.11.004. Epub 2018 Nov 15.
|
| 19 |
The genetic association between alpha-2-macroglobulin (A2M) gene deletion polymorphism and low serum A2M concentration in overweight/obese Thais.Nutr Neurosci. 2006 Feb-Apr;9(1-2):93-8. doi: 10.1080/10284150600771777.
|
| 20 |
Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection.Arthritis Res Ther. 2017 Jul 25;19(1):175. doi: 10.1186/s13075-017-1363-4.
|
| 21 |
Cerebrospinal Fluid Proteomics For Identification Of 2-Macroglobulin As A Potential Biomarker To Monitor Pharmacological Therapeutic Efficacy In Dopamine Dictated Disease States Of Parkinson's Disease And Schizophrenia.Neuropsychiatr Dis Treat. 2019 Oct 2;15:2853-2867. doi: 10.2147/NDT.S214217. eCollection 2019.
|
| 22 |
PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones.Prostate. 2018 Aug;78(11):819-829. doi: 10.1002/pros.23539. Epub 2018 Apr 16.
|
| 23 |
Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.J Biol Chem. 2005 Jul 15;280(28):26278-86. doi: 10.1074/jbc.M414467200. Epub 2005 May 20.
|
| 24 |
Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency.Hum Genet. 1989 Aug;83(1):93-6. doi: 10.1007/BF00274157.
|
| 25 |
-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L179-90. doi: 10.1152/ajplung.00179.2014.
|
| 26 |
The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia.Mol Neurobiol. 2020 Feb;57(2):778-797. doi: 10.1007/s12035-019-01737-z. Epub 2019 Aug 31.
|
| 27 |
Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib.Pediatr Res. 2018 May;83(5):982-992. doi: 10.1038/pr.2018.9. Epub 2018 Feb 28.
|
| 28 |
Alpha 2 macroglobulin activity in rats infected with Typanosoma lewisi and treated with cyclophosphamide and its effect on the malignancy of the disease.J Vector Borne Dis. 2007 Jun;44(2):128-36.
|
| 29 |
2-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:2M Levels Are Associated with Venous Thromboembolism.Thromb Haemost. 2018 Apr;118(4):630-638. doi: 10.1055/s-0038-1629902. Epub 2018 Feb 15.
|
| 30 |
The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease.Metallomics. 2013 May;5(5):532-40. doi: 10.1039/c3mt20243g. Epub 2013 Mar 21.
|
| 31 |
Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications.Curr Opin Pulm Med. 2011 Dec;17 Suppl 1:S11-9. doi: 10.1097/01.mcp.0000410743.98087.12.
|
| 32 |
A monoclonal antibody recognizes structural variation in cystic fibrosis alpha 2-macroglobulin.Pediatr Res. 1984 Oct;18(10):999-1004. doi: 10.1203/00006450-198410000-00018.
|
| 33 |
Cancer-related anemia in a rat model: alpha2-macroglobulin from Yoshida sarcoma shortens erythrocyte survival.Eur J Haematol. 2002 Jan;68(1):42-8. doi: 10.1034/j.1600-0609.2002.00543.x.
|
| 34 |
A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.Melanoma Res. 2012 Jun;22(3):225-35. doi: 10.1097/CMR.0b013e32835312fd.
|
| 35 |
Early supplemental 2-macroglobulin attenuates cartilage and bone damage by inhibiting inflammation in collagen II-induced arthritis model.Int J Rheum Dis. 2019 Apr;22(4):654-665. doi: 10.1111/1756-185X.13457. Epub 2019 Jan 4.
|
| 36 |
Differences in elastase-binding activity of alpha 1-protease inhibitor and alpha 2-macroglobulin for asthma patients and control subjects with various alpha 1-protease inhibitor phenotypes.Clin Chem. 1993 Apr;39(4):675-9.
|
| 37 |
Interferon gamma up-regulates alpha 2 macroglobulin expression in human astrocytoma cells.J Neuroimmunol. 1994 Aug;53(1):31-7. doi: 10.1016/0165-5728(94)90061-2.
|
| 38 |
Superinduction of interleukin 8 mRNA in activated monocyte derived macrophages from rheumatoid arthritis patients.Ann Rheum Dis. 1999 Oct;58(10):648-52. doi: 10.1136/ard.58.10.648.
|
| 39 |
Serum monomeric 2-macroglobulin as a clinical biomarker in diabetes.Atherosclerosis. 2013 May;228(1):270-6. doi: 10.1016/j.atherosclerosis.2013.02.035. Epub 2013 Mar 13.
|
| 40 |
The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
|
| 41 |
Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
|
| 42 |
Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
|
| 43 |
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
|
| 44 |
Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
|
| 45 |
Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
|
| 46 |
The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy. Int J Oncol. 2006 Jul;29(1):261-8.
|
| 47 |
Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
|
| 48 |
Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
|
| 49 |
Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
|
| 50 |
Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
|
| 51 |
Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
|
| 52 |
Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
|
| 53 |
Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
|
| 54 |
Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
|
| 55 |
Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
|
| 56 |
Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
|
| 57 |
Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia. Proteomics Clin Appl. 2015 Oct;9(9-10):907-16. doi: 10.1002/prca.201400148. Epub 2015 May 15.
|
| 58 |
Plasma proteinase inhibitor activity and hemostasis tests in children with nephrotic syndrome. Effect of prednisone alone and prednisone plus epsilon-aminocaproic acid treatment regimens: a preliminary report. Am J Ther. 2001 Mar-Apr;8(2):97-107. doi: 10.1097/00045391-200103000-00004.
|
| 59 |
Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
|
| 60 |
Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
|
| 61 |
Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
|
| 62 |
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
|
| 63 |
Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
|
| 64 |
Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
|
| 65 |
Activated 2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. J Biol Chem. 2015 Apr 10;290(15):9571-87. doi: 10.1074/jbc.M114.617837. Epub 2015 Feb 26.
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