Details of Disease

General Information of Disease (ID: DIS2G3HU)

• Disease Name: Drug abuse
• Disease Class: 6C4G: Psychoactive substances use disorder
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DIS2G3HU: Drug abuse
• ICD Code:
  ICD-11: ICD-11: 6C4G.1Z
  ICD-10: ICD-10: F19
  Expand ICD-11: '6C4G
  Expand ICD-10: 'F19
  Expand ICD-9: 303304
• Disease Identifiers:
  MedGen ID: 41659
  SNOMED CT ID: 26416006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lorcaserin	DMG6OYJ	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GSK598809	DMGU05N	Phase 2	NA	[2]
GSK618334	DMJPXZ4	Phase 1	Small molecular drug	[3]

This Disease is Treated as An Indication in 5 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
18-Methoxycoronaridine	DMTJ384	Investigative	Small molecular drug	[4]
CGP-44532	DMKF0GH	Investigative	Small molecular drug	[5]
CM-156	DM7TX3D	Investigative	NA	[6]
Dibenzothiazepines	DMEDKA3	Investigative	NA	[7]
InterveXin-PCP	DMF0SOG	Investigative	NA	[8]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2941).
• [2] ClinicalTrials.gov (NCT01188967) Effectiveness of GSK598809, a Selective D3 Antagonist, Added to Cognitive Behavioral Therapy and Nicotine Replacement Therapy for Smoking Cessation and Prevention of Very Early Relapse to Smoking. U.S. National Institutes of Health.
• [3] ClinicalTrials.gov (NCT00513279) To Investigate If Single Doses Of GSK618334 Are Safe And To Investigate Blood Levels Of GSK618334. U.S. National Institutes of Health.
• [4] Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. Eur J Pharmacol. 2002 Mar 1;438(1-2):99-105.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1082).
• [6] Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
• [7] Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. J Med Chem. 2009 Apr 9;52(7):1975-82
• [8] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.