Details of the Drug

General Information of Drug (ID: DMEDKA3)

Drug Name

Dibenzothiazepines

Synonyms

Cannabinoid CB1 inverse agonists (CNS disorder); Cannabinoid CB1 inverse agonists (CNS disorder), ACADIA; CB1 inverse agonists (obesity, substance abuse), ACADIA

Indication

Disease Entry	ICD 11	Status	REF
Drug abuse	6C4G.1Z	Investigative	[1]
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Structure

3D Structure is Not Available

3D MOL

2D MOL

Cross-matching ID

TTD ID: D09QLR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Agonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Drug abuse

ICD Disease Classification

6C4G.1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 1 (CB1)	DTT	CNR1	5.59E-02	-0.22	-0.45
Cannabinoid receptor 1 (CB1)	DTT	CNR1	7.68E-01	-0.06	-0.46

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. J Med Chem. 2009 Apr 9;52(7):1975-82
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).