Details of Disease

General Information of Disease (ID: DIS2H763)

• Disease Name: Acute respiratory distress syndrome
• Synonyms: ALI; acute lung injury; non-cardiogenic pulmonary oedema; Stiff lung; increased-permeability pulmonary edema; non-cardiogenic pulmonary edema; increased-permeability pulmonary oedema; shock lung; acute respiratory distress syndrome; ARDS
• Disease Class: CB00: Acute respiratory distress syndrome
• Definition: Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition.|This disease can present as a mild ARDS (PaO2/FiO2 of 201?00mmHg) moderate ARDS (PaO2/FiO2 of 101?00mmHg) and severe ARDS (PaO2/FiO2 ?00mmHg). [PMID:30872586]
• Disease Hierarchy:
  DIS6SVEE: Syndromic disease
  DIS5KQ5Y: Acute respiratory failure
  DIS2H763: Acute respiratory distress syndrome
• ICD Code:
  ICD-11: ICD-11: CB00
  ICD-10: ICD-10: J80
• Disease Identifiers:
  MONDO ID: MONDO_0006502
  MESH ID: D012128
  UMLS CUI: C2887484
  MedGen ID: 1812214
  HPO ID: HP:0033677

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BAY1097761	DMCM5Z1	Phase 2	NA	[1]

This Disease is Treated as An Indication in 3 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DD7	DMV0JQG	Investigative	Aptamer	[2]
ED1	DM5QS17	Investigative	Aptamer	[2]
ED45	DMX32JY	Investigative	Aptamer	[2]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] ClinicalTrials.gov (NCT04417036) Safety and Efficacy of Inhaled Pegylated Adrenomedullin (PEG-ADM) in Patients Suffering From Acute Respiratory Distress Syndrome (ARDS): a Double-blind, Randomized, Placebo-controlled, Multicenter Phase 2a/b Clinical Trial. U.S.National Institutes of Health.
• [2] Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60.