Details of Disease

General Information of Disease (ID: DIS5KQ5Y)

• Disease Name: Acute respiratory failure
• Synonyms: respiratory failure, acute; acute respiratory failure
• Disease Class: CB41: Respiratory failure
• Definition: Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock.
• Disease Hierarchy:
  DISBV50J: Acute disease
  DISVMYJO: Respiratory failure
  DIS5KQ5Y: Acute respiratory failure
• ICD Code: ICD-11: ICD-11: CB41.0
• Disease Identifiers:
  MONDO ID: MONDO_0001208
  UMLS CUI: C0264490
  MedGen ID: 75540
  SNOMED CT ID: 65710008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Tozorakimab	DMCXN80	Phase 3	Monoclonal antibody	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NPM1	TTHBS98	Disputed	Biomarker	[2]
CBX7	TTBN3HC	moderate	Altered Expression	[3]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC2A10	DT3BI6S	Strong	Biomarker	[4]

This Disease Is Related to 18 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BTBD8	OT3A3RD7	Limited	Genetic Variation	[5]
CHGB	OT7SAQT2	Limited	Altered Expression	[6]
DMTF1	OTDKO9OO	Limited	Altered Expression	[7]
DPYS	OTLTUIVL	Limited	Biomarker	[8]
HUWE1	OTFH6BJS	Limited	Biomarker	[9]
IL2RG	OTRZ3OMY	Limited	Biomarker	[10]
PIK3C3	OTLUM9L7	Limited	Altered Expression	[11]
PPP6R2	OTERHESI	Limited	Genetic Variation	[12]
PRC1	OTHD0XS0	Limited	Biomarker	[13]
RAB11A	OTC4FW0J	Limited	Biomarker	[14]
SFTPA2	OT6SFOMU	Limited	Genetic Variation	[15]
SFTPB	OTOHS07E	Limited	Genetic Variation	[16]
TBX2	OTTOT7A9	Limited	Altered Expression	[17]
CDK5RAP3	OTC0Q2QS	Strong	Biomarker	[18]
CENPJ	OTZCQZN5	Strong	Biomarker	[19]
COL4A5	OTHG60RE	Strong	Biomarker	[4]
RUNX1T1	OT30DED5	Strong	Biomarker	[20]
TBX3	OTM64N7K	Strong	Altered Expression	[21]

References

• [1] ClinicalTrials.gov (NCT05624450) A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen. U.S.National Institutes of Health.
• [2] Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation.Oncogene. 2009 Sep 10;28(36):3209-20. doi: 10.1038/onc.2009.178. Epub 2009 Jun 29.
• [3] Oncogenic role of the chromobox protein CBX7 in gastric cancer.J Exp Clin Cancer Res. 2010 Aug 19;29(1):114. doi: 10.1186/1756-9966-29-114.
• [4] High flow through nasal cannula in exacerbated COPD patients: a systematic review.Pulmonology. 2019 Nov-Dec;25(6):348-354. doi: 10.1016/j.pulmoe.2019.08.001. Epub 2019 Oct 5.
• [5] The -1082 interleukin-10 polymorphism is associated with acute respiratory failure after major trauma: a prospective cohort study.Surgery. 2008 Feb;143(2):233-42. doi: 10.1016/j.surg.2007.07.040. Epub 2007 Dec 27.
• [6] Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study.Biomarkers. 2017 Dec;22(8):775-781. doi: 10.1080/1354750X.2016.1269200. Epub 2017 Jan 3.
• [7] Human DMTF1 antagonizes DMTF1 regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.Biochim Biophys Acta. 2015 Sep;1849(9):1198-208. doi: 10.1016/j.bbagrm.2015.07.009. Epub 2015 Jul 15.
• [8] Efficacy of direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) in rapidly progressive interstitial pneumonias: results of a historical control study and a review of previous studies.Ther Adv Respir Dis. 2017 Jul;11(7):261-275. doi: 10.1177/1753465817708950. Epub 2017 May 30.
• [9] ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.Cell. 2005 Jul 1;121(7):1071-83. doi: 10.1016/j.cell.2005.03.037.
• [10] Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy.Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11730-5. doi: 10.1073/pnas.0603635103. Epub 2006 Jul 24.
• [11] Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival.Oncogene. 2016 Jul 28;35(30):3986-94. doi: 10.1038/onc.2015.480. Epub 2015 Dec 21.
• [12] COPD is independently associated with 6-month survival in patients who have life support withheld in intensive care.Clin Respir J. 2018 Jul;12(7):2249-2256. doi: 10.1111/crj.12899. Epub 2018 May 11.
• [13] Role of the chromobox protein CBX7 in lymphomagenesis.Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. doi: 10.1073/pnas.0608721104. Epub 2007 Mar 20.
• [14] FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.Eur J Neurosci. 2018 Nov;48(9):3082-3096. doi: 10.1111/ejn.14199. Epub 2018 Nov 2.
• [15] Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection.Crit Care. 2014 Jun 20;18(3):R127. doi: 10.1186/cc13934.
• [16] Surfactant protein B intron 4 variation in German patients with COPD and acute respiratory failure.Dis Markers. 2002;18(3):129-36. doi: 10.1155/2002/194075.
• [17] The role of Tbx2 and Tbx3 in mammary development and tumorigenesis.J Mammary Gland Biol Neoplasia. 2004 Apr;9(2):109-18. doi: 10.1023/B:JOMG.0000037156.64331.3f.
• [18] CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.PLoS One. 2012;7(7):e42210. doi: 10.1371/journal.pone.0042210. Epub 2012 Jul 31.
• [19] CPAP by helmet for treatment of acute respiratory failure after pediatric liver transplantation.Pediatr Transplant. 2018 Feb;22(1). doi: 10.1111/petr.13088. Epub 2017 Nov 24.
• [20] The t(8;21) fusion protein contacts co-repressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor.Blood Cells Mol Dis. 2003 Mar-Apr;30(2):177-83. doi: 10.1016/s1079-9796(03)00021-4.
• [21] TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.Cancer Res. 2008 Feb 1;68(3):693-9. doi: 10.1158/0008-5472.CAN-07-5012.