Details of Disease | DrugMAP

General Information of Disease (ID: DIS33112)

Disease Name	Communicating hydrocephalus
Synonyms	non-obstructive hydrocephalus
Definition	An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of impaired cerebrospinal fluid reabsorption by the arachnoid granulations.
Disease Hierarchy	DISIZUF7: Hydrocephalus DIS33112: Communicating hydrocephalus
Disease Identifiers	MONDO ID MONDO_0002045 MESH ID D006849 UMLS CUI C0009451 MedGen ID 1058 HPO ID HP:0001334 SNOMED CT ID 271569006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LAMC2	TTNS7H3	Strong	Biomarker	[1]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCND2	OTDULQF9	Limited	Biomarker	[2]
CRPPA	OTC85K8Q	Limited	Biomarker	[3]
HYDIN	OTY88F5F	Strong	Biomarker	[4]
IFT122	OTSK3OAD	Strong	Biomarker	[5]
MPDZ	OT9WY1QM	Strong	Genetic Variation	[6]
SIN3A	OTM8OZWV	Strong	Biomarker	[7]
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⏷ Show the Full List of 6 DOT(s)

References

1	Anatomical characterization of the inferior petrosal sinus and adjacent cerebellopontine angle cistern for development of an endovascular transdural cerebrospinal fluid shunt.J Neurointerv Surg. 2019 Jun;11(6):598-602. doi: 10.1136/neurintsurg-2018-014445. Epub 2019 Jan 9.
2	A Novel CCND2 Mutation in a Previously Reported Case of Megalencephaly and Perisylvian Polymicrogyria with Postaxial Polydactyly and Hydrocephalus.Neuropediatrics. 2018 Jun;49(3):222-224. doi: 10.1055/s-0038-1641722. Epub 2018 Apr 11.
3	Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of -dystroglycan.Nat Genet. 2012 May;44(5):581-5. doi: 10.1038/ng.2253.
4	Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities.Nat Genet. 2008 Dec;40(12):1466-71. doi: 10.1038/ng.279.
5	Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene. Am J Hum Genet. 2010 Jun 11;86(6):949-56. doi: 10.1016/j.ajhg.2010.04.012. Epub 2010 May 20.
6	Compound heterozygous variants in the multiple PDZ domain protein (MPDZ) cause a case of mild non-progressive communicating hydrocephalus.BMC Med Genet. 2018 Mar 2;19(1):34. doi: 10.1186/s12881-018-0540-x.
7	Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nat Genet. 2016 Aug;48(8):877-87. doi: 10.1038/ng.3619. Epub 2016 Jul 11.