Details of Disease

General Information of Disease (ID: DIS3N5H4)

Disease Name Atrioventricular dissociation
Synonyms A-V dissociation; atrioventricular dissociation (disease); atrioventricular dissociation
Definition
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the sinoatrial node and the right atrium (sa block) or between atria and ventricles (av block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Disease Hierarchy
DISYKSRF: Genetic disease
DIS3N5H4: Atrioventricular dissociation
Disease Identifiers
MONDO ID
MONDO_0008848
MESH ID
D006327
UMLS CUI
C0004331
OMIM ID
209600
MedGen ID
2496
HPO ID
HP:0011709
SNOMED CT ID
50799005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CACNA1D TT7RGTM Strong Biomarker [1]
KCNJ5 TTEO25X Strong Therapeutic [1]
SCN10A TT90XZ8 Strong Biomarker [2]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
LMNA OT3SG7ZR Strong Biomarker [3]
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References

1 G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1.
2 Genetic variation in SCN10A influences cardiac conduction.Nat Genet. 2010 Feb;42(2):149-52. doi: 10.1038/ng.516. Epub 2010 Jan 10.
3 Familial progressive sinoatrial and atrioventricular conduction disease of adult onset with sudden death, dilated cardiomyopathy, and brachydactyly. A new type of heart-hand syndrome?. Clin Genet. 2005 Aug;68(2):155-60. doi: 10.1111/j.1399-0004.2005.00476.x.