Details of Disease

General Information of Disease (ID: DIS5NVUG)

• Disease Name: Brainstem neoplasm
• Synonyms: tumor of brain stem; brain stem tumor; neoplasm of the brainstem; tumour of brain stem; brainstem tumor; Brain stem neoplasm; brainstem tumour; brainstem neoplasm (disease); tumor of brainstem; tumour of brainstem; tumor of the brain stem; tumour of the brainstem; tumor of the brainstem; brain stem tumour; tumour of the brain stem; neoplasm of brain stem; neoplasm of the brain stem; neoplasm of brainstem
• Definition: A neoplasm (disease) that involves the brainstem.
• Disease Hierarchy:
  DISTBY9Z: Tumour
  DISOFCZS: Malignant primary brain tumour
  DIS5NVUG: Brainstem neoplasm
• Disease Identifiers:
  MONDO ID: MONDO_0021228
  MESH ID: D020295
  UMLS CUI: C0677866
  MedGen ID: 146207
  SNOMED CT ID: 126961004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Everolimus	DM8X2EH	Approved	Small molecular drug	[1]
Sirolimus	DMGW1ID	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDK4	TT0PG8F	Definitive	Biomarker	[3]
CDK6	TTO0FDJ	Definitive	Biomarker	[3]
CDKN2A	TTFTWQ8	Definitive	Biomarker	[3]
PPM1D	TTENJAB	Definitive	Biomarker	[4]

References

• [1] Everolimus FDA Label
• [2] Sirolimus FDA Label
• [3] PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.PLoS One. 2013 Oct 2;8(10):e77639. doi: 10.1371/journal.pone.0077639. eCollection 2013.
• [4] Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.Nat Genet. 2014 Jul;46(7):726-30. doi: 10.1038/ng.2995. Epub 2014 Jun 1.