Details of Disease

General Information of Disease (ID: DIS625IE)

Disease Name	Complex regional pain syndrome
Synonyms	CRPS; reflex sympathetic dystrophy; Complex regional pain syndromes
Disease Class	8D8A: Focal/segmental autonomic disorder
Definition	Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.
Disease Hierarchy	DISRF1M2: Acute or chronic pain DIS625IE: Complex regional pain syndrome
ICD Code	ICD-11 ICD-11: 8D8A.0
Disease Identifiers	MONDO ID MONDO_0019369 MESH ID D020918 UMLS CUI C0458219 MedGen ID 96846 Orphanet ID 83452 SNOMED CT ID 128200000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NERIDRONIC ACID	DMMPG5V	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
T-121	DMMPD09	Phase 3	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD160	TTOFEAS	Limited	Altered Expression	[2]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
B3GAT1	OTXFP98E	Limited	Altered Expression	[2]
KRT16	OTGA0EQN	Limited	Biomarker	[3]
MCF2L2	OTOGFMIH	Strong	Altered Expression	[4]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Anti-allodynic effect of interleukin 10 in a mouse model of complex regional pain syndrome through reduction of NK1 receptor expression of microglia in the spinal cord.J Pain Res. 2018 Sep 4;11:1729-1741. doi: 10.2147/JPR.S166624. eCollection 2018.
3	Complex regional pain syndrome patient immunoglobulin M has pronociceptive effects in the skin and spinal cord of tibia fracture mice.Pain. 2020 Apr;161(4):797-809. doi: 10.1097/j.pain.0000000000001765.
4	Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part I).Med Sci Monit. 2014 Jun 25;20:1067-77. doi: 10.12659/MSM.890702.