Details of Disease

General Information of Disease (ID: DIS7EDR9)

• Disease Name: Substance use disorder
• Disease Class: 6C4Z: Unspecific substance use disorder
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DIS7EDR9: Substance use disorder
• ICD Code: ICD-11: ICD-11: 6C4Z

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Istradefylline	DM20VSK	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 6 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CPP-115	DMK9NQI	Phase 2	Small molecular drug	[2]
Lobeline	DMT3KB4	Phase 2	Small molecular drug	[3]
18-MC	DMGE3DY	Phase 1	NA	[1]
ANS-6637	DM39QWN	Phase 1	NA	[1]
GS-6637	DMXG3T1	Phase 1	NA	[4]
OMS527	DMO0JP1	Phase 1	Small interfering RNA	[5]

This Disease is Treated as An Indication in 4 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
VP004	DMXK8FQ	Discontinued in Phase 1	Antibody	[6]
CEE-03-320	DMGEFX7	Terminated	NA	[7]
CR-3124	DM1MBG9	Terminated	Small molecular drug	[8]
PNU-96391A	DMLMISK	Terminated	Small molecular drug	[9]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8284).
• [3] Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. J Neurochem. 2013 Oct;127(2):187-98.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040688)
• [5] Clinical pipeline report, company report or official report of Omeros.
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025668)
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007189)
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024202)
• [9] The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9.