Details of Disease

General Information of Disease (ID: DIS7OIK6)

• Disease Name: Autoimmune disorder of the nervous system
• Synonyms: neurologic autoimmune diseases; neurologic autoimmune disease; nervous system immune disorders; nervous system immune diseases; nervous system hypersensitivity reaction type II disease; nervous system autoimmune diseases; nervous system autoimmune disease; immune disorders, nervous system; immune diseases, nervous system; diseases, neurologic autoimmune; disease, neurologic autoimmune; autoimmune nervous system disorder; autoimmune nervous system diseases; autoimmune disorders, nervous system; autoimmune disorders of the nervous system; autoimmune diseases, neurologic; autoimmune diseases, nervous system; autoimmune disease, neurologic; autoimmune disease of nervous system
• Definition: A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis.
• Disease Hierarchy:
  DISCFBRD: Neurological disorder
  DISORMTM: Autoimmune disease
  DIS7OIK6: Autoimmune disorder of the nervous system
• Disease Identifiers:
  MONDO ID: MONDO_0002977
  MESH ID: D020274
  UMLS CUI: C0751871
  MedGen ID: 155946

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MCAM	TTHRE05	moderate	Therapeutic	[1]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
EOMES	OTB9VQFA	Limited	Biomarker	[2]
AMPH	OTWPGWZX	Strong	Biomarker	[3]

References

• [1] Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS.Sci Rep. 2013;3:1687. doi: 10.1038/srep01687.
• [2] Foxo3 Transcription Factor Drives Pathogenic THelper 1 Differentiation by Inducing the Expression of Eomes.Immunity. 2016 Oct 18;45(4):774-787. doi: 10.1016/j.immuni.2016.09.010. Epub 2016 Oct 11.
• [3] Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14.Hum Mol Genet. 1995 Feb;4(2):265-8. doi: 10.1093/hmg/4.2.265.