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Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides. Bioorg Med Chem. 2017 Aug 1;25(15):4076-4087.
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CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity. J Autoimmun. 2019 Jan;96:74-85.
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Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis.J Transl Med. 2019 Dec 16;17(1):420. doi: 10.1186/s12967-019-02176-z.
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Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor autoimmune disorder.J Neuroendocrinol. 2017 Mar;29(3). doi: 10.1111/jne.12461.
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Autoantibodies against N-methyl-d-aspartate receptor 1 in health and disease.Curr Opin Neurol. 2018 Jun;31(3):306-312. doi: 10.1097/WCO.0000000000000546.
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Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility.PLoS One. 2013 Jul 22;8(7):e62743. doi: 10.1371/journal.pone.0062743. Print 2013.
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Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.J Biol Chem. 2012 May 18;287(21):17882-17893. doi: 10.1074/jbc.M111.319020. Epub 2012 Mar 24.
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IL-38: A New Player in Inflammatory Autoimmune Disorders.Biomolecules. 2019 Aug 5;9(8):345. doi: 10.3390/biom9080345.
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Clinical significance and immunobiology of IL-21 in autoimmunity.J Autoimmun. 2019 May;99:1-14. doi: 10.1016/j.jaut.2019.01.013. Epub 2019 Feb 14.
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Allosteric inhibition abrogates dysregulated LFA-1 activation: Structural insight into mechanisms of diminished immunologic disease.Comput Biol Chem. 2018 Apr;73:49-56. doi: 10.1016/j.compbiolchem.2018.02.002. Epub 2018 Feb 5.
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Decreased miR-7 expression in the skin and sera of patients with dermatomyositis.Acta Derm Venereol. 2013 May;93(3):273-6. doi: 10.2340/00015555-1459.
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The potential association of tumor necrosis factor-eta (252 G/A) cytokine gene polymorphism with immune thrombocytopenic purpura among Egyptian children.Hematology. 2018 Jun;23(5):299-303. doi: 10.1080/10245332.2017.1386429. Epub 2017 Oct 12.
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mTORC1 regulates mannose-6-phosphate receptor transport and T-cell vulnerability to regulatory T cells by controlling kinesin KIF13A.Cell Discov. 2017 Apr 25;3:17011. doi: 10.1038/celldisc.2017.11. eCollection 2017.
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Targeting ABL-IRE1 Signaling Spares ER-Stressed Pancreatic Cells to Reverse Autoimmune Diabetes.Cell Metab. 2017 Apr 4;25(4):883-897.e8. doi: 10.1016/j.cmet.2017.03.018.
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ORAI1 mutations abolishing store-operated Ca(2+) entry cause anhidrotic ectodermal dysplasia with immunodeficiency.J Allergy Clin Immunol. 2018 Oct;142(4):1297-1310.e11. doi: 10.1016/j.jaci.2017.10.031. Epub 2017 Nov 16.
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Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus.Hum Immunol. 2003 Feb;64(2):274-84. doi: 10.1016/s0198-8859(02)00804-2.
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PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.J Immunol. 2018 Jul 15;201(2):440-450. doi: 10.4049/jimmunol.1701654. Epub 2018 May 23.
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Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation.J Immunol. 2018 Sep 1;201(5):1389-1399. doi: 10.4049/jimmunol.1800324. Epub 2018 Jul 18.
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Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.Br J Pharmacol. 2018 Jan;175(1):38-52. doi: 10.1111/bph.14069. Epub 2017 Nov 29.
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LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.Nature. 2018 May;557(7703):112-117. doi: 10.1038/s41586-018-0064-8. Epub 2018 Apr 25.
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c-REL and IB(NS) Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.J Immunol. 2017 Aug 1;199(3):920-930. doi: 10.4049/jimmunol.1600877. Epub 2017 Jun 26.
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Epigenetic regulation of agronomical traits in Brassicaceae.Plant Cell Rep. 2018 Jan;37(1):87-101. doi: 10.1007/s00299-017-2223-z. Epub 2017 Oct 20.
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Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves' disease.Endocrine. 2019 Apr;64(1):48-54. doi: 10.1007/s12020-019-01852-w. Epub 2019 Feb 19.
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GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice.Allergy. 2017 Mar;72(3):444-452. doi: 10.1111/all.13005. Epub 2016 Sep 12.
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Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases.Front Immunol. 2019 Sep 24;10:2136. doi: 10.3389/fimmu.2019.02136. eCollection 2019.
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Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.Nat Commun. 2016 Oct 11;7:13048. doi: 10.1038/ncomms13048.
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A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.Immunity. 2016 Feb 16;44(2):368-79. doi: 10.1016/j.immuni.2016.01.019.
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Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.J Immunol. 2017 Aug 1;199(3):974-981. doi: 10.4049/jimmunol.1700088. Epub 2017 Jun 23.
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TWEAK/Fn14 Activation Contributes to the Pathogenesis of Bullous Pemphigoid.J Invest Dermatol. 2017 Jul;137(7):1512-1522. doi: 10.1016/j.jid.2017.03.019. Epub 2017 Mar 27.
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Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes.PLoS One. 2018 Dec 13;13(12):e0208981. doi: 10.1371/journal.pone.0208981. eCollection 2018.
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Rapid isolation of high-affinity human antibodies against the tumor vascular marker Endosialin/TEM1, using a paired yeast-display/secretory scFv library platform.J Immunol Methods. 2011 Jan 5;363(2):221-32. doi: 10.1016/j.jim.2010.09.001. Epub 2010 Sep 15.
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Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.EMBO Rep. 2018 Dec;19(12):e46512. doi: 10.15252/embr.201846512. Epub 2018 Oct 2.
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Doberman pinschers present autoimmunity associated with functional autoantibodies: A model to study the autoimmune background of human dilated cardiomyopathy.PLoS One. 2019 Jul 5;14(7):e0214263. doi: 10.1371/journal.pone.0214263. eCollection 2019.
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The Sympathetic Nervous System Mitigates CNS Autoimmunity via 2-Adrenergic Receptor Signaling in Immune Cells.Cell Rep. 2019 Sep 17;28(12):3120-3130.e5. doi: 10.1016/j.celrep.2019.08.042.
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Alpha-fetoprotein is an autoantigen in hepatocellular carcinoma and juvenile Batten disease.Front Biosci (Landmark Ed). 2020 Jan 1;25(5):912-929. doi: 10.2741/4840.
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Does subclinical hypothyroidism and/or thyroid autoimmunity influence the IVF/ICSI outcome? Review of the literature.Gynecol Endocrinol. 2019;35(sup1):56-59. doi: 10.1080/09513590.2019.1653564.
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Achaete-Scute Homologue 2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjgren Syndrome.Am J Pathol. 2019 Dec;189(12):2414-2427. doi: 10.1016/j.ajpath.2019.08.008. Epub 2019 Sep 17.
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cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing T(regs).Sci Adv. 2019 May 1;5(5):eaaw5422. doi: 10.1126/sciadv.aaw5422. eCollection 2019 May.
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Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9.Nat Commun. 2019 Mar 4;10(1):1012. doi: 10.1038/s41467-019-08868-w.
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CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood.J Immunol. 2019 Dec 15;203(12):3157-3165. doi: 10.4049/jimmunol.1900961. Epub 2019 Nov 1.
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The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt.Gene. 2019 Feb 15;685:164-169. doi: 10.1016/j.gene.2018.11.006. Epub 2018 Nov 3.
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B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.JCI Insight. 2019 Feb 21;4(4):e126136. doi: 10.1172/jci.insight.126136. eCollection 2019 Feb 21.
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CD3G gene defects in familial autoimmune thyroiditis.Scand J Immunol. 2014 Nov;80(5):354-61. doi: 10.1111/sji.12200.
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First-in-human clinical trial to assess pharmacokinetics, pharmacodynamics, safety, and tolerability of iscalimab, an anti-CD40 monoclonal antibody.Am J Transplant. 2020 Feb;20(2):463-473. doi: 10.1111/ajt.15661. Epub 2019 Dec 6.
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Cardiotrophin-Like Cytokine Factor 1 Exhibits a Myeloid-Biased Hematopoietic-Stimulating Function.Front Immunol. 2019 Sep 10;10:2133. doi: 10.3389/fimmu.2019.02133. eCollection 2019.
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CXCL13 is an activity marker for systemic, but not cutaneous lupus erythematosus: a longitudinal cohort study.Arch Dermatol Res. 2018 Aug;310(6):485-493. doi: 10.1007/s00403-018-1836-6. Epub 2018 May 4.
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Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.Nat Med. 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.
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A PHD in immunosuppression: oxygen-sensing pathways regulate immunosuppressive Tregs.J Clin Invest. 2019 Jul 29;129(9):3524-3526. doi: 10.1172/JCI130009. eCollection 2019 Jul 29.
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Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized enolase (methionine sulfoxide 93).Sci Rep. 2019 May 28;9(1):7934. doi: 10.1038/s41598-019-44379-w.
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MicroRNA-326 contributes to autoimmune thyroiditis by targeting the Ets-1 protein.Endocrine. 2018 Jan;59(1):120-129. doi: 10.1007/s12020-017-1465-4. Epub 2017 Nov 27.
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Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.Cell Chem Biol. 2019 May 16;26(5):662-673.e7. doi: 10.1016/j.chembiol.2019.01.012. Epub 2019 Feb 28.
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Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1.Front Immunol. 2019 Nov 25;10:2704. doi: 10.3389/fimmu.2019.02704. eCollection 2019.
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TIGIT signaling restores suppressor function of Th1 Tregs.JCI Insight. 2019 Feb 7;4(3):e124427. doi: 10.1172/jci.insight.124427.
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Identification of a c Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21.Gastroenterology. 2020 Feb;158(3):625-637.e13. doi: 10.1053/j.gastro.2019.10.006. Epub 2019 Oct 14.
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Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo.Sci Transl Med. 2018 Jul 18;10(450):eaam7710. doi: 10.1126/scitranslmed.aam7710.
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Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies.J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgz239. doi: 10.1210/clinem/dgz239.
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A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation.PLoS One. 2019 Apr 25;14(4):e0215963. doi: 10.1371/journal.pone.0215963. eCollection 2019.
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Characterization of the Effect of Renal Impairment on Upadacitinib Pharmacokinetics.J Clin Pharmacol. 2019 Jun;59(6):856-862. doi: 10.1002/jcph.1375. Epub 2019 Jan 11.
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MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis.Front Immunol. 2019 Apr 26;10:903. doi: 10.3389/fimmu.2019.00903. eCollection 2019.
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Interactions between hematopoietic progenitor kinase 1 and its adaptor proteins (Review).Mol Med Rep. 2017 Nov;16(5):6472-6482. doi: 10.3892/mmr.2017.7494. Epub 2017 Sep 13.
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Exploring the Protective Role and the Mechanism of Sphingosine 1 Phosphate in Endotoxic Cardiomyocytes.Shock. 2019 Oct;52(4):468-476. doi: 10.1097/SHK.0000000000001270.
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Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity.Biomolecules. 2019 Nov 13;9(11):737. doi: 10.3390/biom9110737.
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Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5.J Cell Physiol. 2019 Aug;234(8):14270-14284. doi: 10.1002/jcp.28126. Epub 2019 Jan 15.
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Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity.Neurology. 2019 Aug 20;93(8):e815-e822. doi: 10.1212/WNL.0000000000007971. Epub 2019 Jul 17.
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microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.J Clin Invest. 2019 Mar 1;129(3):1257-1271. doi: 10.1172/JCI124725. Epub 2019 Feb 11.
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Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity.Nat Commun. 2017 May 22;8:14945. doi: 10.1038/ncomms14945.
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PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185(erbB2/neu) Tumor Immunotherapy.Front Immunol. 2019 Feb 8;10:174. doi: 10.3389/fimmu.2019.00174. eCollection 2019.
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Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice.PLoS One. 2019 Aug 22;14(8):e0221528. doi: 10.1371/journal.pone.0221528. eCollection 2019.
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HIC2, a new transcription activator of SIRT1.FEBS Lett. 2019 Jul;593(14):1763-1776. doi: 10.1002/1873-3468.13456. Epub 2019 Jun 4.
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T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response.J Neuroinflammation. 2019 Jul 3;16(1):133. doi: 10.1186/s12974-019-1523-3.
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Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity.Clin Immunol. 2020 Jan;210:108316. doi: 10.1016/j.clim.2019.108316. Epub 2019 Nov 23.
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Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IB- expression.Biochem Biophys Res Commun. 2020 Jan 22;521(4):957-963. doi: 10.1016/j.bbrc.2019.11.036. Epub 2019 Nov 9.
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The Profile of Toll-like Receptor 2 (TLR2), TLR4 and Their Cytosolic Downstream Signaling Pathway in Common Variable Immunodeficiency (CVID) Patients.Iran J Allergy Asthma Immunol. 2018 Apr;17(2):188-200.
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CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.Genes Immun. 2019 Feb;20(2):103-111. doi: 10.1038/s41435-018-0011-6. Epub 2018 Feb 23.
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FN14 Signaling Plays a Pathogenic Role in a Mouse Model of Experimental Autoimmune Myocarditis.J Card Fail. 2019 Aug;25(8):674-685. doi: 10.1016/j.cardfail.2019.06.003. Epub 2019 Jun 15.
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Vasoactive intestinal peptide ameliorates renal injury in a pristane-induced lupus mouse model by modulating Th17/Treg balance.BMC Nephrol. 2019 Sep 5;20(1):350. doi: 10.1186/s12882-019-1548-y.
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The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease.J Immunol. 2005 Jun 15;174(12):8173-82. doi: 10.4049/jimmunol.174.12.8173.
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Adenosine deaminase activity in type 2 diabetes mellitus: does it have any role?.BMC Endocr Disord. 2018 Aug 20;18(1):58. doi: 10.1186/s12902-018-0284-9.
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The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura.Hum Immunol. 2017 Feb;78(2):80-87. doi: 10.1016/j.humimm.2016.11.005. Epub 2016 Nov 17.
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DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models.Arthritis Res Ther. 2019 Dec 16;21(1):290. doi: 10.1186/s13075-019-2074-9.
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