Details of Disease

General Information of Disease (ID: DIS7WG2P)

Disease Name	Sexual dysfunction
Synonyms	sexual dysfunctions, physiological; sexual disorders, physiological; sexual disorder, physiological; physiological sexual dysfunctions; physiological sexual disorders; sexual dysfunction; Sex disorders; physiological sexual dysfunction; physiological sexual disorder
Disease Class	HA00-HA01: Sexual dysfunction
Definition	Physiological disturbances in normal sexual performance in either the male or the female.
Disease Hierarchy	DIS7W23Z: Reproductive system disorder DIS7WG2P: Sexual dysfunction
ICD Code	ICD-11 ICD-11: HA00-HA01
Disease Identifiers	MONDO ID MONDO_0002134 MESH ID D012735 UMLS CUI C0237873 MedGen ID 66756

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Apomorphine	DMX38HQ	Approved	Small molecular drug	[1]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AMG 386	DMQJXL4	Phase 3	Small molecular drug	[2]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NMI-870	DMU596F	Discontinued in Phase 2	NA	[3]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 2 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
IDDBCP-150101	DMQ3BXV	Preclinical	NA	[2]
Melanotetan II	DMYK8MV	Preclinical	Small molecular drug	[2]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PRL	TTJ2TSA	moderate	Biomarker	[4]
PTGER1	TTG1QMU	moderate	Therapeutic	[5]
PTGER2	TT1ZAVI	moderate	Therapeutic	[5]
PTGER4	TT79WV3	moderate	Therapeutic	[5]
------------------------------------------------------------------------------------

References

1	Intranasal apomorphine. Nastech Pharmaceutical. IDrugs. 2004 May;7(5):483-8.
2	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014166)
4	Sexual dysfunction associated with neuroleptic-induced hyperprolactinemia improves with reduction in prolactin levels.Ann N Y Acad Sci. 2004 Dec;1032:289-90. doi: 10.1196/annals.1314.041.
5	Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates.Dev Neurobiol. 2008 Oct;68(12):1406-19. doi: 10.1002/dneu.20665.