Details of Disease

General Information of Disease (ID: DIS876UA)

• Disease Name: Insulin-resistant disorder
• Disease Class: 5A44: Insulin-resistance syndrome
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DIS876UA: Insulin-resistant disorder
• ICD Code:
  ICD-11: ICD-11: 5A44
  ICD-10: ICD-10: E10-E14
  Expand ICD-11: '5A44
  Expand ICD-10: 'E10-E14

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dichloroacetate	DMZ5Y1P	Phase 4	Small molecular drug	[1]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
LIM-0705	DM9ZHRS	Phase 2	NA	[2]
Aminoguanidine	DMJQDUC	Phase 1	Small molecular drug	[3]
BVS857	DMYSXRZ	Phase 1	NA	[4]
MK-0249	DMAPV6J	Clinical trial	Small molecular drug	[5]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PD-2024	DM5WV6R	Investigative	NA	[6]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] ClinicalTrials.gov (NCT02469337) Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance (CARBEX). U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT01364155) Safety, Tolerability, PK, and PD of LIM-0705 in Subjects With Impaired Glucose Tolerance or Abnormal HOMA-IR. U.S. National Institutes of Health.
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018258)
• [4] ClinicalTrials.gov (NCT01435330) Safety and Tolerability of BVS857 in Subjects With Insulin Resistance. U.S. National Institutes of Health.
• [5] (11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists. J Nucl Med. 2014 Jan;55(1):65-72.
• [6] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.