General Information of Disease (ID: DIS88NSA)

Disease Name Infective endocarditis
Synonyms endocarditis, infective; endocarditis infective
Definition
Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called 'endocarditis,' although it is important to distinguish it from non-infective endocarditis. IE is caused bybacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damagethe heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.
Disease Hierarchy
DISBU610: Endocarditis
DISEM33Q: Infectious disease
DIS88NSA: Infective endocarditis
Disease Identifiers
MONDO ID
MONDO_0000565
UMLS CUI
C1541923
MedGen ID
323818
Orphanet ID
570762
SNOMED CT ID
233850007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AQP9 TTQEI32 Strong Biomarker [1]
MTM1 TTY2TCU Strong Biomarker [2]
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This Disease Is Related to 8 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CNMD OTHND8EL moderate Biomarker [3]
ARSD OTAHW9M8 Strong Biomarker [4]
CYP4V2 OTQKNK0D Strong Biomarker [5]
ITGA2B OT4Y17PY Strong Biomarker [6]
MANEA OTV7L8I6 Strong Biomarker [7]
MCF2L2 OTOGFMIH Strong Biomarker [8]
NLRP6 OTEREN4W Strong Biomarker [9]
MAVS OTTQ0J64 Definitive Biomarker [10]
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⏷ Show the Full List of 8 DOT(s)

References

1 The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis.PLoS One. 2012;7(2):e31490. doi: 10.1371/journal.pone.0031490. Epub 2012 Feb 3.
2 Multilocus sequence typing analysis of Streptococcus mutans strains with the cnm gene encoding collagen-binding adhesin.J Med Microbiol. 2011 Nov;60(Pt 11):1677-1684. doi: 10.1099/jmm.0.033415-0. Epub 2011 Jun 16.
3 Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease.Cell Mol Life Sci. 2019 Nov;76(22):4493-4502. doi: 10.1007/s00018-019-03225-y. Epub 2019 Jul 17.
4 Infective endocarditis after device closure of atrial septal defects: Case report and review of the literature.Catheter Cardiovasc Interv. 2017 Feb 1;89(2):324-334. doi: 10.1002/ccd.26784. Epub 2016 Sep 19.
5 Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early endocarditis.Infect Immun. 2013 Mar;81(3):697-703. doi: 10.1128/IAI.01030-12. Epub 2012 Dec 17.
6 Multiple sites on Streptococcus gordonii surface protein PadA bind to platelet GPIIbIIIa.Thromb Haemost. 2013 Dec;110(6):1278-1287. doi: 10.1160/TH13-07-0580. Epub 2013 Oct 17.
7 Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study.Eur Heart J. 2019 Oct 14;40(39):3222-3232. doi: 10.1093/eurheartj/ehz620.
8 Increasing incidence of IV-drug use associated endocarditis in southern West Virginia and potential economic impact.Clin Cardiol. 2019 Apr;42(4):432-437. doi: 10.1002/clc.23162. Epub 2019 Mar 14.
9 Incidence and factors associated with infective endocarditis in patients undergoing left-sided heart valve replacement.Eur Heart J. 2018 Jul 21;39(28):2668-2675. doi: 10.1093/eurheartj/ehy153.
10 Heterogeneous vancomycin-intermediate susceptibility in a community-associated methicillin-resistant Staphylococcus aureus epidemic clone, in a case of Infective Endocarditis in Argentina.Ann Clin Microbiol Antimicrob. 2011 Apr 28;10:15. doi: 10.1186/1476-0711-10-15.