Details of Disease

General Information of Disease (ID: DISBU610)

Disease Name	Endocarditis
Synonyms	endocarditis (disease); endocarditis; inflammation of endocardium; endocardium inflammation
Disease Class	BB40-BA42: Endocarditis
Definition	Inflammation of the endocardium.
Disease Hierarchy	DISYWOR8: Inflammation of heart layer DISK2J0F: Endocardium disorder DISWD40R: Disease DISBU610: Endocarditis
ICD Code	ICD-11 ICD-11: BB40-BA42 ICD-10 ICD-10: I38 ICD-9 ICD-9: 421 Expand ICD-11 'BC0Z; 'BB4Z Expand ICD-10 'I38 Expand ICD-9 421
Disease Identifiers	MONDO ID MONDO_0005025 MESH ID D004696 UMLS CUI C0014118 MedGen ID 4940 HPO ID HP:0100584 SNOMED CT ID 56819008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Flucytosine	DM13VTW	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Garenoxacin	DMZXA0W	Terminated	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CS	TTZA6B3	Disputed	Biomarker	[3]
SERPINH1	TTPSWQG	moderate	Biomarker	[4]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC9A6	DTN0JXW	Strong	Biomarker	[5]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SMOX	DEOH5V3	Disputed	Biomarker	[6]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HCCS	OTQE88BE	Limited	Genetic Variation	[7]
ARHGEF40	OTFSKXG9	Disputed	Genetic Variation	[8]
MUC7	OTSTMP0X	Disputed	Biomarker	[9]
PHF20	OTCBVH5P	Disputed	Biomarker	[10]
SESTD1	OTHH06X8	Disputed	Genetic Variation	[8]
TNIP1	OTRAOTEW	moderate	Biomarker	[11]
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⏷ Show the Full List of 6 DOT(s)

References

1	Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.
2	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
3	Use of polymerase chain reaction for citrate synthase gene to diagnose Bartonella quintana endocarditis.Am J Clin Pathol. 1999 Jul;112(1):36-40. doi: 10.1093/ajcp/112.1.36.
4	Virulence and antimicrobial resistance in clinical Enterococcus faecium.Int J Antimicrob Agents. 2008 Nov;32(5):374-7. doi: 10.1016/j.ijantimicag.2008.04.026. Epub 2008 Aug 19.
5	Utility of qSOFA score in identifying patients at risk for poor outcome in Staphylococcus aureus bacteremia.BMC Infect Dis. 2019 Feb 13;19(1):149. doi: 10.1186/s12879-019-3770-4.
6	In vivo impact of the MexAB-OprM efflux system on beta-lactam efficacy in an experimental model of Pseudomonas aeruginosa infection.Int J Antimicrob Agents. 2009 May;33(5):417-20. doi: 10.1016/j.ijantimicag.2008.10.029. Epub 2009 Jan 20.
7	Macrolide-resistant pneumococcal endocarditis and epidural abscess that develop during erythromycin therapy.Clin Infect Dis. 2003 Jan 15;36(2):e19-25. doi: 10.1086/344965. Epub 2003 Jan 7.
8	Is the Freedom SOLO Stentless Bioprosthesis a Useful Tool for Patients with Aortic Endocarditis and Aortic Annular Destruction?.Thorac Cardiovasc Surg. 2019 Dec;67(8):644-651. doi: 10.1055/s-0038-1668134. Epub 2018 Aug 16.
9	Streptococcal Siglec-like adhesins recognize different subsets of human plasma glycoproteins: implications for infective endocarditis.Glycobiology. 2018 Aug 1;28(8):601-611. doi: 10.1093/glycob/cwy052.
10	Pseudomonas Endocarditis with an unstable phenotype: the challenges of isolate characterization and Carbapenem stewardship with a partial review of the literature.Antimicrob Resist Infect Control. 2017 Aug 29;6:87. doi: 10.1186/s13756-017-0245-5. eCollection 2017.
11	AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis.Antimicrob Agents Chemother. 2017 May 24;61(6):e02486-16. doi: 10.1128/AAC.02486-16. Print 2017 Jun.