Details of Disease

Disease Name

Legionnaires' disease

infection by Legionella pneumophilia; legionnaire's disease; Legionella; Legionella pneumonia; Legionnaires' Disease

Definition

A pneumonia caused by Legionella pneumophila and other Legionella species, which is characterized by fever, cough, progressive respiratory distress, and which is often accompanied by extrapulmonary manifestations.

Disease Hierarchy

DISHA0ML: Legionellosis

DISPW7PH: Bacterial pneumonia

DIS8V4GQ: Legionnaires' disease

Disease Identifiers

MONDO ID

MONDO_0005824

MESH ID

D007877

UMLS CUI

C0023241

MedGen ID

9705

SNOMED CT ID

195889001

General Information of Disease (ID: DIS8V4GQ)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Erythromycin	DM4K7GQ	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TNFRSF1A	TTG043C	moderate	Biomarker	[2]
TNFRSF1B	TT63WSF	moderate	Biomarker	[2]
TLR5	TTCXP8J	Definitive	Genetic Variation	[3]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MIP	OTEBLU3E	Strong	Genetic Variation	[4]
NAIP	OTLA925F	Strong	Genetic Variation	[5]
NFE2	OTLM94BI	Strong	Biomarker	[6]
NTAN1	OTJF0U48	Strong	Biomarker	[7]
PSMC5	OTJOORMR	Strong	Biomarker	[6]
TOLLIP	OTYEO4NR	Strong	Biomarker	[8]
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⏷ Show the Full List of 6 DOT(s)

References

1	Erythromycin FDA Label
2	TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice.Cytokine. 2008 Nov;44(2):298-303. doi: 10.1016/j.cyto.2008.08.015. Epub 2008 Oct 5.
3	Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam.J Infect Dis. 2005 Apr 1;191(7):1068-71. doi: 10.1086/428593. Epub 2005 Feb 28.
4	Application of Legionella pneumophila-specific quantitative real-time PCR combined with direct amplification and sequence-based typing in the diagnosis and epidemiological investigation of Legionnaires' disease.Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):2017-28. doi: 10.1007/s10096-011-1535-0. Epub 2012 Jan 26.
5	Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection.Hum Immunol. 2012 Feb;73(2):196-200. doi: 10.1016/j.humimm.2011.10.014. Epub 2011 Oct 23.
6	Legionnaires' Disease Mortality in Guinea Pigs Involves the p45 Mobile Genomic Element.J Infect Dis. 2019 Oct 8;220(10):1700-1710. doi: 10.1093/infdis/jiz340.
7	microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.PLoS One. 2017 Apr 26;12(4):e0176204. doi: 10.1371/journal.pone.0176204. eCollection 2017.
8	TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.Mucosal Immunol. 2019 Nov;12(6):1382-1390. doi: 10.1038/s41385-019-0196-7. Epub 2019 Aug 28.