Details of Disease

Disease Name

Multibacillary leprosy

lepromatous leprosy; multibacillary leprosy

Definition

A lepromatous form of leprosy that is characterized by numerous infiltrated skin lesions displaying high bacillary loads, impaired peripheral nerves, possible involvement of internal organs, and a Th2-mediated immune response.

Disease Hierarchy

DISAA4UI: Leprosy

DIS90T7X: Multibacillary leprosy

Disease Identifiers

MONDO ID

MONDO_0041751

MESH ID

D056006

UMLS CUI

C1562585

MedGen ID

288329

SNOMED CT ID

416257001

General Information of Disease (ID: DIS90T7X)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clofazimine	DMEBOFW	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LTA4H	TTXZEAJ	Strong	Genetic Variation	[2]
MRC1	TTKV8W5	Strong	Genetic Variation	[3]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NEBL	OT2WH1NC	Strong	Genetic Variation	[4]
PARL	OT7DMHSA	Strong	Genetic Variation	[5]
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References

1	Clofazimine FDA Label
2	The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.Cell. 2010 Mar 5;140(5):717-30. doi: 10.1016/j.cell.2010.02.013.
3	Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.Hum Genet. 2012 Jul;131(7):1251-60. doi: 10.1007/s00439-012-1153-7. Epub 2012 Mar 6.
4	CUBN and NEBL common variants in the chromosome 10p13 linkage region are associated with multibacillary leprosy in Vietnam.Hum Genet. 2014 Jul;133(7):883-93. doi: 10.1007/s00439-014-1430-8. Epub 2014 Feb 23.
5	Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.Sci Rep. 2016 Nov 23;6:37086. doi: 10.1038/srep37086.