Details of Disease

Disease Name

Hansen disease; Mycobacterium leprae disease or disorder; Mycobacterium leprae infectious disease; Mycobacterium leprae caused disease or disorder; Hansen's disease

Definition

Leprosy is a chronic infectious disease affecting primarily the skin and peripheral nervous system.

Disease Hierarchy

DIS8ZVFW: Primary bacterial infectious disease

DISNSMUD: Mycobacterium infection

DISEM33Q: Infectious disease

DISAA4UI: Leprosy

Disease Identifiers

MONDO ID

MONDO_0005124

MESH ID

D007918

UMLS CUI

C0023343

MedGen ID

6049

Orphanet ID

548

SNOMED CT ID

81004002

General Information of Disease (ID: DISAA4UI)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clofazimine	DMEBOFW	Approved	Small molecular drug	[1]
Dapsone	DM4LT8A	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 25 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL1RL1	TT4GZA4	Limited	Genetic Variation	[3]
MBL2	TTMQDZ5	Limited	Genetic Variation	[4]
CFP	TTLA0VS	Disputed	Biomarker	[5]
HSD11B2	TT9H85R	Disputed	Altered Expression	[6]
IL10RB	TTJTRMK	Disputed	Biomarker	[7]
IL17F	TT2B6PS	Disputed	Altered Expression	[6]
S100A6	TT716MY	Disputed	Biomarker	[8]
RIPK2	TTCQ2E5	moderate	Genetic Variation	[9]
CD209	TTBXIM9	Strong	Biomarker	[10]
FMNL1	TTW20PQ	Strong	Biomarker	[11]
HLA-B	TTGS10J	Strong	Biomarker	[12]
HSPE1	TTWYMFE	Strong	Biomarker	[13]
IL13RA1	TTNEAMG	Strong	Genetic Variation	[14]
IL23R	TT6H4QR	Strong	Genetic Variation	[15]
IL5RA	TTXH9AD	Strong	Biomarker	[14]
LRRK2	TTK0FEA	Strong	Biomarker	[16]
LTA	TTP73TM	Strong	Biomarker	[17]
MAP3K14	TT4LIAC	Strong	Biomarker	[11]
MASP2	TTR01E9	Strong	Genetic Variation	[18]
SDHD	TTVH9W8	Strong	Altered Expression	[19]
TIRAP	TTKU0LS	Strong	Genetic Variation	[20]
TLR1	TTW14D0	Strong	Genetic Variation	[21]
TLR2	TTY7ZHS	Strong	Altered Expression	[22]
TNFSF15	TTEST6I	Strong	Altered Expression	[23]
IL12B	TTGW72V	Definitive	Biomarker	[7]
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⏷ Show the Full List of 25 DTT(s)

This Disease Is Related to 4 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC26A3	DTN1FMD	Disputed	Biomarker	[24]
SLC7A9	DTP7AEQ	Disputed	Biomarker	[7]
SLC2A13	DT0NSKB	moderate	Genetic Variation	[3]
SLC11A1	DT650XW	Strong	Genetic Variation	[25]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
PCK1	DEPLH5Z	Strong	Biomarker	[26]
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This Disease Is Related to 40 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BBS9	OT23V9YF	Limited	Genetic Variation	[27]
EMC3	OTY2H39E	Limited	Biomarker	[28]
IL18R1	OT83XMPQ	Limited	Genetic Variation	[3]
LACC1	OT4SBHI8	Limited	Genetic Variation	[29]
PACRG	OT1NYNNW	Limited	Biomarker	[30]
PRKN	OTJBN41W	Limited	Genetic Variation	[31]
RBM45	OTWTHD77	Limited	Genetic Variation	[32]
DDX39A	OT0Z6E1K	Disputed	Biomarker	[7]
DDX39B	OTEVCFVU	Disputed	Biomarker	[7]
TOLLIP	OTYEO4NR	Disputed	Biomarker	[33]
CDH18	OTC06P9H	moderate	Genetic Variation	[3]
COX4I1	OTU0FC24	moderate	Genetic Variation	[3]
FILIP1	OTMZD6D4	moderate	Genetic Variation	[9]
RMI2	OTA0HP4S	moderate	Genetic Variation	[3]
SIGLEC5	OTYC440J	moderate	Genetic Variation	[3]
SNX20	OTNL4B1S	moderate	Genetic Variation	[3]
ADGB	OT1TM9DT	Strong	Genetic Variation	[15]
BATF3	OTI61WXQ	Strong	Biomarker	[3]
C1orf141	OTASPHL0	Strong	Genetic Variation	[3]
CCDC122	OTYJQAVG	Strong	Genetic Variation	[34]
CCDC88B	OTEDUI2J	Strong	Biomarker	[3]
FCN1	OTK6ZHXH	Strong	Genetic Variation	[35]
FCN3	OTPRENLS	Strong	Biomarker	[36]
GAL3ST4	OTCXGJGO	Strong	Genetic Variation	[37]
HLA-DRB4	OTNXIHQU	Strong	Biomarker	[38]
IL10RA	OTOX3D1D	Strong	Biomarker	[14]
IL26	OT2WYCW4	Strong	Biomarker	[39]
IRGM	OTKD3O5Z	Strong	Genetic Variation	[40]
MAVS	OTTQ0J64	Strong	Genetic Variation	[41]
MICA	OTPEIEAR	Strong	Biomarker	[42]
NFKBIL1	OTYFTPS0	Strong	Biomarker	[7]
NT5C3A	OT67KZJA	Strong	Biomarker	[43]
NUPR1	OT4FU8C0	Strong	Biomarker	[44]
PARL	OT7DMHSA	Strong	Biomarker	[45]
SLAMF1	OTBTT3ZQ	Strong	Altered Expression	[46]
SPAG8	OTZC5XP9	Strong	Altered Expression	[6]
TNFSF8	OTDYGDJ3	Strong	Genetic Variation	[47]
TOR1B	OTNEL2PZ	Strong	Biomarker	[48]
BTNL2	OTTTEMZA	Definitive	Genetic Variation	[7]
RAB32	OTTR4H7S	Definitive	Genetic Variation	[15]
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⏷ Show the Full List of 40 DOT(s)

References

1	Clofazimine FDA Label
2	Dapsone FDA Label
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33	Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist.J Infect Dis. 2016 Apr 1;213(7):1189-97. doi: 10.1093/infdis/jiv570. Epub 2015 Nov 26.
34	Association between genetic variants in NOD2, C13orf31, and CCDC122 genes and leprosy among the Chinese Yi population.Int J Dermatol. 2016 Jan;55(1):65-9. doi: 10.1111/ijd.12981. Epub 2015 Jul 31.
35	Susceptibility to leprosy is associated with M-ficolin polymorphisms.J Clin Immunol. 2013 Jan;33(1):210-9. doi: 10.1007/s10875-012-9770-4. Epub 2012 Sep 1.
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40	Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines.Inflammation. 2014 Apr;37(2):593-8. doi: 10.1007/s10753-013-9773-1.
41	Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China.Infect Genet Evol. 2016 Nov;45:105-110. doi: 10.1016/j.meegid.2016.08.021. Epub 2016 Aug 21.
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44	The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy.PLoS Negl Trop Dis. 2019 Jul 25;13(7):e0007589. doi: 10.1371/journal.pntd.0007589. eCollection 2019 Jul.
45	Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.Sci Rep. 2016 Nov 23;6:37086. doi: 10.1038/srep37086.
46	Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns.J Immunol. 2001 Nov 15;167(10):5719-24. doi: 10.4049/jimmunol.167.10.5719.
47	Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se.J Infect Dis. 2015 Mar 15;211(6):968-77. doi: 10.1093/infdis/jiu566. Epub 2014 Oct 15.
48	Leprosy in a high-prevalence Egyptian village: epidemiology and risk factors.Int J Dermatol. 2002 Oct;41(10):681-6. doi: 10.1046/j.1365-4362.2002.01602.x.