Details of Disease | DrugMAP

General Information of Disease (ID: DIS9H7BS)

Disease Name	Demyelinating disease of central nervous system
Synonyms	demyelinating disorders of the central nervous system; demyelinating disease of central nervous system; demyelinating disorder of central nervous system; demyelinating CNS disease; demyelinating disease central nervous system (CNS)
Definition	Any condition in which there is degeneration of the myelin sheath that covers the nerves of the central nervous system.
Disease Hierarchy	: DIS9H7BS: Demyelinating disease of central nervous system
Disease Identifiers	MONDO ID MONDO_0020800 UMLS CUI C0011302 MedGen ID 3719 SNOMED CT ID 6118003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MOG	TTQAFX5	Strong	Biomarker	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AQP4	OTA9MYD5	Strong	Altered Expression	[2]
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References

1	Defining distinct features of anti-MOG antibody associated central nervous system demyelination.Ther Adv Neurol Disord. 2018 Mar 29;11:1756286418762083. doi: 10.1177/1756286418762083. eCollection 2018.
2	Association Between the Single Nucleotide Polymorphism and the Level of Aquaporin-4 Protein Expression in Han and Minority Chinese with Inflammatory Demyelinating Diseases of the Central Nervous System.Mol Neurobiol. 2016 Jul;53(5):2878-2885. doi: 10.1007/s12035-015-9171-9. Epub 2015 Apr 18.