Details of Disease

Disease Name

Trichomoniasis

infections, Trichomonas; Trichomonas infection

Definition

An infection that is caused by Trichomonas.

Disease Hierarchy

DIS57EB5: Protozoa infectious disease

DISEM33Q: Infectious disease

DIS9HBNL: Trichomoniasis

Disease Identifiers

MONDO ID

MONDO_0002154

MESH ID

D014245

UMLS CUI

C0040921

MedGen ID

52838

SNOMED CT ID

105648001

General Information of Disease (ID: DIS9HBNL)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Metronidazole	DMTIVEN	Approved	Small molecular drug	[1]
Tindamax	DM3OWT4	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTN2	OT9FOLD7	Strong	Biomarker	[3]
FMN1	OT9CID5R	Strong	Biomarker	[4]
MTA2	OTCCYIQJ	Strong	Biomarker	[5]
NAGA	OTNUEUZY	Strong	Genetic Variation	[6]
PPIP5K1	OT06HYH8	Strong	Biomarker	[7]
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References

1	Metronidazole FDA Label
2	Tinidazole (Tindamax)--a new option for treatment of bacterial vaginosis. Med Lett Drugs Ther. 2007 Sep 10;49(1269):73-4.
3	Role of -Actinin 2 in Cytoadherence and Cytotoxicity of Trichomonas vaginalis.J Microbiol Biotechnol. 2017 Oct 28;27(10):1844-1854. doi: 10.4014/jmb.1706.06050.
4	Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines.Front Microbiol. 2017 Mar 17;8:398. doi: 10.3389/fmicb.2017.00398. eCollection 2017.
5	Video-based education versus nurse-led education for partner notification in Thai women with sexually transmitted infections: a randomized controlled trial.Int J STD AIDS. 2018 Nov;29(11):1076-1083. doi: 10.1177/0956462418775507. Epub 2018 May 22.
6	Sexually Transmitted Infections: A Novel Screening Strategy for Improving Women's Health in Vulnerable Populations.Int J Mol Sci. 2017 Jun 20;18(6):1311. doi: 10.3390/ijms18061311.
7	A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis.Mol Biochem Parasitol. 2019 Jan;227:53-63. doi: 10.1016/j.molbiopara.2018.12.004. Epub 2018 Dec 26.