Details of Disease | DrugMAP

General Information of Disease (ID: DISAE27V)

Disease Name	IgE responsiveness, atopic
Synonyms	IgE response underlying allergic asthma and rhinitis; Immunoglobulin E, basic level of, in serum; atopy, susceptibility to; IGER; IgE, level of; Atopic hypersensitivity; IgE responsiveness, ATOPIC; type I immediate hypersensitivity reaction; IgE responsiveness, atopic; type I hypersensitivity; type 1 hypersensitivity reaction; type I hypersensitivity reaction; type 1 hypersensitivity; IgE, elevated level of; immediate hypersensitivity
Definition	Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.
Disease Hierarchy	DISTCP41: Atopic dermatitis DISAE27V: IgE responsiveness, atopic
Disease Identifiers	MONDO ID MONDO_0007817 MESH ID C564133 UMLS CUI C1840253 OMIM ID 147050 MedGen ID 327063

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL4R	TTDWHC3	No Known	Unknown	[1]
------------------------------------------------------------------------------------

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
IL4R	OTTXOTCW	No Known	Unknown	[1]
MS4A2	OTMCAS2D	No Known	Unknown	[2]
SPINK5	OT61IIAO	Strong	Biomarker	[3]
------------------------------------------------------------------------------------

References

1	The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
2	Screening of the Fc epsilon RI-beta-gene in a Swiss population of asthmatic children: no association with E237G and identification of new sequence variations. Dis Markers. 1998 Nov;14(3):177-86. doi: 10.1155/1998/940356.
3	Netherton syndrome: disease expression and spectrum of SPINK5 mutations in 21 families.J Invest Dermatol. 2002 Feb;118(2):352-61. doi: 10.1046/j.1523-1747.2002.01603.x.