Details of Disease

General Information of Disease (ID: DISAG9IO)

Disease Name Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8
Synonyms encephalopathy, ACUTE, infection-induced (HERPES-specific), susceptibility to, 8; IIAE8; Herpes simplex encephalitis, Susceptibility to, 6
Disease Hierarchy
DISWHADJ: Encephalitis, acute, infection-induced, susceptibility to
DISAG9IO: Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8
Disease Identifiers
MONDO ID
MONDO_0054754
UMLS CUI
C4693542
OMIM ID
617900
MedGen ID
1646997

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
TBK1 TTH5TC2 Limited Autosomal dominant [1]
TBK1 TTMP03S Strong Biomarker [2]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
TBK1 OT1P06NV Limited Autosomal dominant [1]
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References

1 Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med. 2012 Aug 27;209(9):1567-82. doi: 10.1084/jem.20111316. Epub 2012 Jul 30.
2 Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.Genes Immun. 2015 Dec;16(8):552-66. doi: 10.1038/gene.2015.46. Epub 2015 Oct 29.