Details of Disease

General Information of Disease (ID: DISAIQP2)

Disease Name	Aspergillosis
Synonyms	infection due to Aspergillus
Disease Class	1F20: Aspergillosis
Definition	Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
Disease Hierarchy	DIS67GEL: Opportunistic mycosis DISEM33Q: Infectious disease DISAIQP2: Aspergillosis
ICD Code	ICD-11 ICD-11: 1F20 ICD-10 ICD-10: B44, B44.9 Expand ICD-11 '1F20 Expand ICD-10 'B44; 'B44.9
Disease Identifiers	MONDO ID MONDO_0005657 MESH ID D001228 UMLS CUI C0004030 MedGen ID 13939 Orphanet ID 1163 SNOMED CT ID 65553006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Anidulafungin	DM8QM5U	Approved	Small molecular drug	[2]
Itraconazole	DMCR1MV	Approved	Small molecular drug	[3]
Micafungin	DM6Y3AN	Approved	Small molecular drug	[4]
Posaconazole	DMUL5EW	Approved	Small molecular drug	[5]
Voriconazole	DMAOL2S	Approved	Small molecular drug	[6]
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⏷ Show the Full List of 6 Drug(s)

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
L-733560	DMYZPJU	Terminated	NA	[7]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MAT-401	DMU95YY	Investigative	NA	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Amphotericin B FDA Label
2	Anidulafungin FDA Label
3	Itraconazole FDA Label
4	Micafungin FDA Label
5	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022003.
6	Voriconazole FDA Label
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003552)
8	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.