Details of Disease

General Information of Disease (ID: DISB8YKA)

Disease Name Polyomavirus infection
Disease Class 1C80: Viral encephalitis
Definition
Infections with polyomavirus, which are often cultured from the urine of kidney transplant patients. Excretion of bk virus is associated with ureteral strictures and cystitis, and that of jc virus with progressive multifocal leukoencephalopathy (leukoencephalopathy, progressive multifocal).
Disease Hierarchy
DISDI77C: Primary viral infectious disease
DISEM33Q: Infectious disease
DISB8YKA: Polyomavirus infection
ICD Code
ICD-11
ICD-11: 1C80
ICD-10
ICD-10: B97.89
Disease Identifiers
MONDO ID
MONDO_0005927
MESH ID
D027601
UMLS CUI
C0949804
MedGen ID
215447
SNOMED CT ID
407457004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
IkT-004 DM8YDUY Investigative NA [1]
IkT-014 DMHMKJ1 Investigative NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CCL11 TTCF05Y Strong Biomarker [2]
HGF TT4V2JM Strong Biomarker [2]
IL15 TTJFA35 Strong Biomarker [2]
IL18 TTRICUF Strong Biomarker [2]
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This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CCL4 OT6B8P25 Strong Biomarker [2]
GPR179 OTJN40Z7 Strong Biomarker [3]
RAB18 OTNMAQLS Strong Biomarker [4]
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References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Increased levels of C-C chemokine RANTES in asbestos exposed workers and in malignant mesothelioma patients from an hyperendemic area.PLoS One. 2014 Aug 27;9(8):e104848. doi: 10.1371/journal.pone.0104848. eCollection 2014.
3 Role of a nuclear localization signal on the minor capsid proteins VP2 and VP3 in BKPyV nuclear entry.Virology. 2015 Jan 1;474:110-6. doi: 10.1016/j.virol.2014.10.013. Epub 2014 Nov 14.
4 Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen.mSphere. 2017 Jul 26;2(4):e00291-17. doi: 10.1128/mSphereDirect.00291-17. eCollection 2017 Jul-Aug.