Details of Disease

General Information of Disease (ID: DISBCAC5)

Disease Name Non-typhoidal salmonella
Synonyms iNTS disease; invasive non-typhoidal salmonella disease
Disease Class 1A09: Salmonella infection
Definition
Invasive non-typhoidal salmonellosis (iNTS) is a rare bacterial infectious disease caused by extraintestinal infection of non-typhoidal serotypes of Salmonella enterica in patients with underlying HIV infection, malaria or malignancy. It has a high mortality rate and patients typically present with fever, pallor and respiratory signs (cough, tachnypnea, pneumonia). Gastrointestinal manifestations (diarrhea, vomit, abdominal pain) are not common. Occasionally, organ absseses, septic shock and meningitis may be observed.
Disease Hierarchy
DISTJ434: Salmonella infection
DISBCAC5: Non-typhoidal salmonella
ICD Code
ICD-11
ICD-11: 1A09
Disease Identifiers
MONDO ID
MONDO_0017944
UMLS CUI
C4706572
MedGen ID
1638286
Orphanet ID
324648
SNOMED CT ID
763772002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
GSK4077164A DMQXOSZ Phase 1 Vaccine [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
STAT4 OTAK3VFR Strong Genetic Variation [2]
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References

1 Clinical pipeline report, company report or official report of GlaxoSmithKline
2 Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.Nat Commun. 2018 Mar 9;9(1):1014. doi: 10.1038/s41467-017-02398-z.