Details of Disease

General Information of Disease (ID: DISTJ434)

• Disease Name: Salmonella infection
• Synonyms: infections, Salmonella; rare form of salmonellosis; Salmonella infection
• Disease Class: 1A09: Salmonella infection
• Definition: Infections with bacteria of the genus salmonella.
• Disease Hierarchy:
  DIS8ZVFW: Primary bacterial infectious disease
  DISEM33Q: Infectious disease
  DISTJ434: Salmonella infection
• ICD Code:
  ICD-11: ICD-11: 1A09
  ICD-10: ICD-10: A02.9
  Expand ICD-11: '1C41
  Expand ICD-10: 'A02.9
• Disease Identifiers:
  MONDO ID: MONDO_0000827
  MESH ID: D012480
  UMLS CUI: C0036117
  MedGen ID: 48542
  Orphanet ID: 795
  SNOMED CT ID: 302231008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Salmonella typhi vaccine	DMRLZWK	Approved	NA	[1]
Typherix	DMVRKSK	Approved	NA	[1]
Typhim Vi	DMECKGY	Approved	NA	[1]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vi-CRM197	DMAU66C	Phase 2	NA	[2]
BB IND-6989	DMZ20TY	Phase 1	NA	[3]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
FB-1811	DMLS2B5	Investigative	NA	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 9 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HDAC11	TT8K17W	moderate	Biomarker	[5]
IL12B	TTGW72V	moderate	Biomarker	[6]
ALPL	TTMR5UV	Strong	Biomarker	[7]
CLEC12A	TT70N8V	Strong	Biomarker	[8]
IL23A	TTC1GLB	Strong	Genetic Variation	[9]
LILRB2	TTHC6XU	Strong	Altered Expression	[10]
LILRB4	TTREOKA	Strong	Altered Expression	[10]
SLC40A1	TT6Y1PG	Strong	Altered Expression	[11]
UCHL5	TTSX29Z	Strong	Biomarker	[12]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
IL12RB1	OTM1IJO2	moderate	Altered Expression	[13]
CYRIB	OTLRN4L1	Strong	Biomarker	[14]
IFITM3	OT2QP8D3	Strong	Biomarker	[15]
NLRC4	OTAIA3NA	Strong	Altered Expression	[16]
PERP	OTP0YL53	Strong	Biomarker	[17]
SNX1	OTXQSJ1J	Strong	Biomarker	[18]
SPI1	OTVCA1D0	Strong	Biomarker	[19]
SUMF2	OT37I8JL	Strong	Biomarker	[20]
TMUB1	OTR4RO3N	Strong	Biomarker	[7]
TRIM32	OTJOV0PG	Strong	Biomarker	[21]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] ClinicalTrials.gov (NCT01438996) Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults. U.S. National Institutes of Health.
• [3] ClinicalTrials.gov (NCT00277147) Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine. U.S. National Institutes of Health.
• [4] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [5] Glycyrrhizic acid activates chicken macrophages and enhances their Salmonella-killing capacity in vitro.J Zhejiang Univ Sci B. 2018 Oct.;19(10):785-795. doi: 10.1631/jzus.B1700506.
• [6] Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseases.Int J Immunogenet. 2006 Jun;33(3):231-2. doi: 10.1111/j.1744-313X.2006.00591.x.
• [7] Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication.PLoS Pathog. 2017 Oct 30;13(10):e1006700. doi: 10.1371/journal.ppat.1006700. eCollection 2017 Oct.
• [8] Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.Cell Rep. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18.
• [9] Bacille Calmette-Gurin infection and disease with fatal outcome associated with a point mutation in the interleukin-12/interleukin-23 receptor beta-1 chain in two Mexican families.Int J Infect Dis. 2010 Sep;14 Suppl 3:e256-60. doi: 10.1016/j.ijid.2009.11.005. Epub 2010 Feb 19.
• [10] The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.BMC Immunol. 2009 Oct 27;10:56. doi: 10.1186/1471-2172-10-56.
• [11] High Dietary Iron Differentially Influences the Iron Distribution in the Livers and the Spleens of Laying Hens After Salmonella Typhimurium Infection.Biol Trace Elem Res. 2018 Oct;185(2):497-508. doi: 10.1007/s12011-018-1275-4. Epub 2018 Feb 24.
• [12] Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.PLoS One. 2015 Aug 12;10(8):e0135531. doi: 10.1371/journal.pone.0135531. eCollection 2015.
• [13] Mendelian susceptibility to mycobacterial disease: Clinical and immunological findings of patients suspected for IL12R1 deficiency.Allergol Immunopathol (Madr). 2019 Sep-Oct;47(5):491-498. doi: 10.1016/j.aller.2019.02.004. Epub 2019 Jul 23.
• [14] CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.Nat Microbiol. 2019 Sep;4(9):1516-1531. doi: 10.1038/s41564-019-0484-8. Epub 2019 Jul 8.
• [15] Cloning of IP15, a pancreatitis-induced gene whose expression inhibits cell growth.Biochem Biophys Res Commun. 2004 Jul 2;319(3):1001-9. doi: 10.1016/j.bbrc.2004.05.085.
• [16] SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells.Virulence. 2018;9(1):1390-1402. doi: 10.1080/21505594.2018.1509664.
• [17] The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.Gut Microbes. 2016;7(2):136-45. doi: 10.1080/19490976.2015.1128626.
• [18] Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection.J Cell Sci. 2008 Jun 15;121(Pt 12):2027-36. doi: 10.1242/jcs.018432. Epub 2008 May 27.
• [19] S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia.Front Cell Infect Microbiol. 2019 May 31;9:187. doi: 10.3389/fcimb.2019.00187. eCollection 2019.
• [20] Molecular characterization and resistance profile of Salmonella Enteritidis PT4 and PT9 strains isolated in Brazil.J Med Microbiol. 2011 Jul;60(Pt 7):1026-1031. doi: 10.1099/jmm.0.028597-0. Epub 2011 Apr 1.
• [21] SseK3 Is a Salmonella Effector That Binds TRIM32 and Modulates the Host's NF-B Signalling Activity.PLoS One. 2015 Sep 22;10(9):e0138529. doi: 10.1371/journal.pone.0138529. eCollection 2015.