Details of Disease

General Information of Disease (ID: DISBX8WG)

Disease Name Secretory diarrhea
Definition Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption.
Disease Hierarchy
DISQRVLK: Diarrhea
DISBX8WG: Secretory diarrhea
Disease Identifiers
MONDO ID
MONDO_0000249
UMLS CUI
C0267557
MedGen ID
75635
HPO ID
HP:0005208
SNOMED CT ID
15699003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
IL13RA1 TTNEAMG Limited Altered Expression [1]
CFTR TTRLZHP Strong Biomarker [2]
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This Disease Is Related to 5 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ANO6 OTTA5KQJ Limited Altered Expression [3]
GUCA2A OTUSF75G Limited Biomarker [4]
GUCA2B OTZERX04 Limited Biomarker [4]
TAPBP OTL81AVZ Limited Altered Expression [5]
MYO5B OTCKL3W3 Strong Genetic Variation [6]
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References

1 Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.J Biol Chem. 2011 Apr 15;286(15):13357-69. doi: 10.1074/jbc.M110.214965. Epub 2011 Feb 8.
2 Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea.J Infect Dis. 2019 Oct 22;220(11):1719-1728. doi: 10.1093/infdis/jiz013.
3 Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA.J Biol Chem. 2016 Dec 23;291(52):26816-26836. doi: 10.1074/jbc.M116.719823. Epub 2016 Oct 31.
4 Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology.Regul Pept. 1999 May 31;81(1-3):25-39. doi: 10.1016/s0167-0115(99)00033-6.
5 Antidiarrheal activity of -terpineol in mice.Biomed Pharmacother. 2019 Feb;110:631-640. doi: 10.1016/j.biopha.2018.11.131. Epub 2018 Dec 9.
6 Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects.Mol Biol Cell. 2019 Dec 15;30(26):3076-3089. doi: 10.1091/mbc.E18-07-0415. Epub 2019 Oct 30.