Details of Disease

General Information of Disease (ID: DISCXJBH)

• Disease Name: Angiogenesis disorder
• Disease Class: BE2Z: Circulatory system disease
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISCXJBH: Angiogenesis disorder
• ICD Code:
  ICD-11: ICD-11: BE2Z
  ICD-10: ICD-10: I00-I99

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BMS-986183	DMFBUTF	Phase 1/2	NA	[1]

This Disease is Treated as An Indication in 3 Patented Agent(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Antibodie derivative 10	DMGP5AR	Patented	Antibody	[1]
Carboxylic acid derivative 1	DM86E2P	Patented	Small molecular drug	[1]
Methyl-piperidine compound 1	DM5PS6K	Patented	Small molecular drug	[1]

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Neutralase	DMXHWK6	Discontinued in Phase 3	NA	[2]
YM-337	DMCZIGQ	Discontinued in Phase 2	NA	[3]

This Disease is Treated as An Indication in 8 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CLT-005	DM0DRHD	Investigative	NA	[4]
CLT-009	DM0M7JN	Investigative	NA	[4]
GKT-04	DMTCZ32	Investigative	NA	[4]
Heparan sulfate	DMML0QS	Investigative	Small molecular drug	[4]
IB-09A133	DM6PL9Q	Investigative	NA	[4]
IB-09C190	DMDCCPF	Investigative	NA	[4]
JNJ-38158471	DM48Y9E	Investigative	Small molecular drug	[5]
NP-184	DMLZPRJ	Investigative	NA	[4]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
• [2] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007559)
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005765)
• [4] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813).