Details of Disease

General Information of Disease (ID: DISDKAQY)

• Disease Name: Skin ulcer
• Synonyms: callous ulcer (morphologic abnormality); callous ulcer; indolent ulcer; indolent ulcer (morphologic abnormality)
• Disease Class: ME60: Skin lesion
• Disease Hierarchy:
  DIS9YPUQ: Dermatological disease
  DISDKAQY: Skin ulcer
• ICD Code: ICD-11: ICD-11: ME60.Z
• Disease Identifiers:
  MONDO ID: MONDO_0004605
  MESH ID: D012883
  UMLS CUI: C0157738
  MedGen ID: 510410
  HPO ID: HP:0200042
  SNOMED CT ID: 19429009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bucladesine sodium	DM8E4MO	Approved	Small molecular drug	[1]
Silver sulfadiazine	DMVTHWQ	Approved	Small molecular drug	[2]
Sulfadiazine	DMTW3R8	Approved	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
EIF2AK1	TTRUJBV	Strong	Biomarker	[4]
PDGFA	TTSM78N	Strong	Biomarker	[5]
PDGFRA	TT8FYO9	Strong	Biomarker	[5]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCRL2	OT5PX0RX	Strong	Biomarker	[4]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Silver sulfadiazine FDA Label
• [3] Sulfadiazine FDA Label
• [4] HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes.J Invest Dermatol. 2003 Dec;121(6):1360-4. doi: 10.1046/j.1523-1747.2003.12642.x.
• [5] [The expression of platelet-derived growth factor-A and its receptor in acute radiation-induced skin ulcer in rats].Zhonghua Shao Shang Za Zhi. 2005 Oct;21(5):359-62.