Details of Disease

General Information of Disease (ID: DISEEX9F)

Disease Name	Cytomegalovirus Disease
Synonyms	cytomegalovirus pneumonia; Cytomegalovirus caused pneumonia; Cytomegalovirus pneumonia; Cytomegaloviral pneumonia; CMV pneumonia
Disease Class	1D82: Cytomegaloviral disease
Definition	Pneumonia caused by cytomegalovirus. Most humans are exposed to cytomegalovirus. Healthy individuals do not develop signs and symptoms of infection. Patients with weakened immune system (e.g., AIDS patients, cancer patients who are being treated with chemotherapy, and patients who have received bone marrow or solid organ transplants) develop signs and symptoms of infection. They include cough, shortness of breath, fatigue, malaise, fever, muscle and joint pain, and excessive sweating.
Disease Hierarchy	DIS8EF3M: Pneumonia DISCEMGC: Cytomegalovirus infection DISENI5X: Viral pneumonia DISEEX9F: Cytomegalovirus Disease
ICD Code	ICD-11 ICD-11: 1D82 Expand ICD-11 '1D82 Expand ICD-10 'B25; 'B25.0; 'B25.8; 'B25.9
Disease Identifiers	MONDO ID MONDO_0024354 UMLS CUI C0276253 MedGen ID 124443 SNOMED CT ID 7678002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MK-8228	DMOB58Q	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
HB-101	DM2XPTS	Phase 2	Vaccine	[2]
mRNA-1647	DMNCP20	Phase 2	Vaccine	[3]
Pepvax	DMLCZNB	Phase 2	NA	[4]
VBI-1501	DMB4TVO	Phase 1	Vaccine	[4]
Viralym-C	DM3O6JD	Phase 1	Cell therapy	[5]
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This Disease is Treated as An Indication in 1 Patented Agent(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzimidazole	DM1IZA7	Patented	Small molecular drug	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SLC27A4	TT20AYF	Limited	Biomarker	[7]
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References

1	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2	ClinicalTrials.gov (NCT03629080) A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT04232280) Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647 in Healthy Adults. U.S. National Institutes of Health.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	ClinicalTrials.gov (NCT02313857) Most Closely Human Leukocyte Antigen (HLA)-Matched CMV-specific T Lymphocytes (Viralym-C). U.S. National Institutes of Health.
6	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
7	Cytomegalovirus (CMV) DNA Quantitation in Bronchoalveolar Lavage Fluid From Hematopoietic Stem Cell Transplant Recipients With CMV Pneumonia.J Infect Dis. 2017 May 15;215(10):1514-1522. doi: 10.1093/infdis/jix048.