Details of Disease | DrugMAP

General Information of Disease (ID: DISFH29B)

Disease Name	Coronary artery disease, autosomal dominant 2
Synonyms	ADCAD2; LRP6 coronary artery disease; coronary artery disease, autosomal dominant 2; coronary artery disease, autosomal dominant, 2; coronary artery disease caused by mutation in LRP6; coronary artery disease, autosomal dominant type 2
Definition	Any coronary artery disease in which the cause of the disease is a mutation in the LRP6 gene.
Disease Hierarchy	DIS5OIP1: Coronary heart disease DISMT2VZ: Cardiogenetic disease DISFH29B: Coronary artery disease, autosomal dominant 2
Disease Identifiers	MONDO ID MONDO_0012586 MESH ID C567045 UMLS CUI C1970440 OMIM ID 610947 MedGen ID 370259

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LRP6	TTSXOWE	Limited	Unknown	[1]
LRP6	TTSXOWE	Strong	Genetic Variation	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
LRP6	OTM7PSUR	Limited	Unknown	[1]
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References

1	LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science. 2007 Mar 2;315(5816):1278-82. doi: 10.1126/science.1136370.
2	Rare nonconservative LRP6 mutations are associated with metabolic syndrome.Hum Mutat. 2013 Sep;34(9):1221-5. doi: 10.1002/humu.22360. Epub 2013 Jun 18.